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JOANNA JANKOWSKY

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neurology
    DivisionNeurology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neurosurgery
    DivisionNeurosurgery

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


    Collapse Research 
    Collapse research activities and funding
    R01AG085751     (JANKOWSKY, JOANNA L)May 15, 2024 - Feb 28, 2029
    NIH
    Causes and consequences of differential APP processing in inhibitory and excitatory neurons
    Role: Principal Investigator
    R01AG074009     (LICHTARGE, OLIVIER)Sep 15, 2021 - Jun 30, 2026
    NIH
    Decoding the impact of sex differences on Alzheimer's disease risk
    Role: Co-Principal Investigator
    R01AG069721     (JANKOWSKY, JOANNA L)Aug 15, 2021 - Jul 31, 2026
    NIH
    Gene therapy for Alzheimer's disease using virally delivered A? variants
    Role: Principal Investigator
    RF1AG069721     (JANKOWSKY, JOANNA L)Aug 15, 2021 - Jul 31, 2024
    NIH
    Gene therapy for Alzheimer's disease using virally delivered Aß variants
    Role: Principal Investigator
    RF1AG058188     (JANKOWSKY, JOANNA L)Sep 15, 2017 - Mar 31, 2022
    NIH
    Plasticity of the entorhinal-hippocampal circuit as a vulnerability in AD
    Role: Principal Investigator
    R21AG056028     (JANKOWSKY, JOANNA L)Jul 15, 2017 - Apr 30, 2021
    NIH
    Modeling genetic modifiers of cognitive reserve in AD
    Role: Principal Investigator
    RF1AG054160     (JANKOWSKY, JOANNA L)Aug 15, 2016 - Mar 31, 2021
    NIH
    Interrogating the link between aging and AD with temporally-controlled transgenes
    Role: Principal Investigator
    R01NS092615     (JANKOWSKY, JOANNA L)Jul 15, 2015 - Jun 30, 2020
    NIH
    Deconstructing the pathogenic effect of APP in memory circuits
    Role: Principal Investigator
    R21MH101583     (JANKOWSKY, JOANNA L)Jun 24, 2013 - May 31, 2017
    NIH
    Selective neuronal silencing to study hippocampal neurogenesis in depression
    Role: Principal Investigator
    R21AG038856     (JANKOWSKY, JOANNA L)Sep 30, 2010 - Aug 31, 2013
    NIH
    Distinguishing cell-intrinsic and cell-extrinsic effects of APP/Abeta in vivo
    Role: Principal Investigator
    DP2OD001734     (JANKOWSKY, JOANNA L)Sep 30, 2007 - Aug 31, 2012
    NIH
    Selective neuronal silencing to study cognitive decline in Alzheimer's disease
    Role: Principal Investigator
    K01AG026144     (JANKOWSKY, JOANNA L)Sep 30, 2004 - Aug 31, 2010
    NIH
    Interaction of ABeta &the alpha7 AChR in mouse AD model
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wood CA, Somasundaram P, Dundee JM, Rudy MA, Watkins TA, Jankowsky JL. Chemogenetic neuronal silencing decouples c-Jun activation from cell death in the temporal cortex. Eur J Neurosci. 2024 Dec; 60(11):6704-6719. PMID: 39449079.
      Citations:    Translation:AnimalsCells
    2. Borgenheimer E, Trueblood C, Nguyen BL, Lagor WR, Jankowsky JL. Simple improvements in vector design afford substantial gains in AAV delivery of aggregation-slowing A? variants. Mol Ther Nucleic Acids. 2024 Dec 10; 35(4):102314. PMID: 39296331; PMCID: PMC11406023.
      Citations:    
    3. Edwards GA, Wood CA, He Y, Nguyen Q, Kim PJ, Gomez-Gutierrez R, Park KW, Xu Y, Zurhellen C, Al-Ramahi I, Jankowsky JL. TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. Acta Neuropathol. 2024 03 25; 147(1):61. PMID: 38526616.
      Citations: 6     Fields:    Translation:HumansAnimals
    4. Koller EJ, Wood CA, Lai Z, Borgenheimer E, Hoffman KL, Jankowsky JL. Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response. J Neuroinflammation. 2024 Jan 04; 21(1):11. PMID: 38178148; PMCID: PMC10765643.
      Citations: 1     Fields:    Translation:Animals
    5. Perez GA, Park KW, Lanza D, Cicardo J, Uddin MD, Jankowsky JL. Generation of a Dcx-CreERT2 knock-in mouse for genetic manipulation of newborn neurons. Genesis. 2024 02; 62(1):e23584. PMID: 38102875; PMCID: PMC11021165.
      Citations:    Fields:    Translation:AnimalsCells
    6. Nguyen Q, Wood CA, Kim PJ, Jankowsky JL. The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons. Front Neurosci. 2023; 17:1275959. PMID: 37901434; PMCID: PMC10603297.
      Citations:    
    7. Lusk S, Ward CS, Chang A, Twitchell-Heyne A, Fattig S, Allen G, Jankowsky JL, Ray RS. An automated respiratory data pipeline for waveform characteristic analysis. J Physiol. 2023 11; 601(21):4767-4806. PMID: 37786382; PMCID: PMC10841337.
      Citations: 1     Fields:    Translation:HumansAnimals
    8. Zhang T, Pang W, Feng T, Guo J, Wu K, Nunez Santos M, Arthanarisami A, Nana AL, Nguyen Q, Kim PJ, Jankowsky JL, Seeley WW, Hu F. TMEM106B regulates microglial proliferation and survival in response to demyelination. Sci Adv. 2023 05 05; 9(18):eadd2676. PMID: 37146150; PMCID: PMC10162677.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. Edwards GA, Wood CA, Nguyen Q, Kim PJ, Gomez-Gutierrez R, Park KW, Zurhellen C, Al-Ramahi I, Jankowsky JL. TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. bioRxiv. 2023 Mar 25. PMID: 36993574; PMCID: PMC10055407.
      Citations:    
    10. Koller EJ, Comstock M, Bean JC, Escobedo G, Park KW, Jankowsky JL. Correction: Temporal and spatially controlled APP transgene expression using Cre-dependent alleles. Dis Model Mech. 2023 Mar 01; 16(3). PMID: 36897116; PMCID: PMC10040240.
      Citations:    Fields:    
    11. Zhao R, Grunke SD, Wood CA, Perez GA, Comstock M, Li MH, Singh AK, Park KW, Jankowsky JL. Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer's circuit dysfunction. Elife. 2022 12 05; 11. PMID: 36468693; PMCID: PMC9873254.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Koller EJ, Comstock M, Bean JC, Escobedo G, Park KW, Jankowsky JL. Temporal and spatially controlled APP transgene expression using Cre-dependent alleles. Dis Model Mech. 2022 05 01; 15(5). PMID: 35394029; PMCID: PMC9118045.
      Citations:    Fields:    Translation:HumansAnimals
    13. Park KW, Wood CA, Li J, Taylor BC, Oh S, Young NL, Jankowsky JL. Gene therapy using A? variants for amyloid reduction. Mol Ther. 2021 07 07; 29(7):2294-2307. PMID: 33647457; PMCID: PMC8261072.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    14. Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Invest. 2020 04 01; 130(4):1912-1930. PMID: 31917687; PMCID: PMC7108898.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    15. Huichalaf CH, Al-Ramahi I, Park KW, Grunke SD, Lu N, de Haro M, El-Zein K, Gallego-Flores T, Perez AM, Jung SY, Botas J, Zoghbi HY, Jankowsky JL. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Hum Mol Genet. 2019 06 15; 28(12):2014-2029. PMID: 30753434; PMCID: PMC6548227.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    16. Lillehaug S, Yetman MJ, Puchades MA, Checinska MM, Kleven H, Jankowsky JL, Bjaalie JG, Leergaard TB. Brain-wide distribution of reporter expression in five transgenic tetracycline-transactivator mouse lines. Sci Data. 2019 02 26; 6:190028. PMID: 30806643; PMCID: PMC6390708.
      Citations:    Fields:    Translation:AnimalsCells
    17. Chiang ACA, Fowler SW, Savjani RR, Hilsenbeck SG, Wallace CE, Cirrito JR, Das P, Jankowsky JL. Combination anti-A? treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018 05 07; 215(5):1349-1364. PMID: 29626114; PMCID: PMC5940263.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Jankowsky JL, Zheng H. Practical considerations for choosing a mouse model of Alzheimer's disease. Mol Neurodegener. 2017 12 22; 12(1):89. PMID: 29273078; PMCID: PMC5741956.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    19. Chiang ACA, Fowler SW, Reddy R, Pletnikova O, Troncoso JC, Sherman MA, Lesne SE, Jankowsky JL. Discrete Pools of Oligomeric Amyloid-? Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis. Am J Pathol. 2018 03; 188(3):739-756. PMID: 29248459; PMCID: PMC5840490.
      Citations: 7     Fields:    Translation:HumansAnimals
    20. Verbeeck C, Carrano A, Chakrabarty P, Jankowsky JL, Das P. Combination of A? Suppression and Innate Immune Activation in the Brain Significantly Attenuates Amyloid Plaque Deposition. Am J Pathol. 2017 Dec; 187(12):2886-2894. PMID: 28919107; PMCID: PMC5718090.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Kim JY, Jang A, Reddy R, Yoon WH, Jankowsky JL. Neuronal overexpression of human VAPB slows motor impairment and neuromuscular denervation in a mouse model of ALS. Hum Mol Genet. 2016 11 01; 25(21):4661-4673. PMID: 28173107; PMCID: PMC6078563.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    22. Zhao R, Grunke SD, Keralapurath MM, Yetman MJ, Lam A, Lee TC, Sousounis K, Jiang Y, Swing DA, Tessarollo L, Ji D, Jankowsky JL. Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability. Cell Rep. 2016 07 19; 16(3):793-804. PMID: 27373150; PMCID: PMC4956499.
      Citations: 9     Fields:    Translation:HumansAnimals
    23. Marin MA, Ziburkus J, Jankowsky J, Rasband MN. Amyloid-? plaques disrupt axon initial segments. Exp Neurol. 2016 07; 281:93-8. PMID: 27109181; PMCID: PMC4877279.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    24. Yetman MJ, Fowler SW, Jankowsky JL. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS One. 2016; 11(4):e0153724. PMID: 27070146; PMCID: PMC4829202.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Lian H, Litvinchuk A, Chiang AC, Aithmitti N, Jankowsky JL, Zheng H. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. J Neurosci. 2016 Jan 13; 36(2):577-89. PMID: 26758846; PMCID: PMC4710776.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    26. Kim JY, Grunke SD, Jankowsky JL. Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection. Methods Mol Biol. 2016; 1382:239-50. PMID: 26611591.
      Citations: 5     Fields:    Translation:AnimalsCells
    27. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA, Vigneau S, G?rtner J. Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 Sep 24; 525(7570):552. PMID: 26176914; PMCID: PMC6451649.
      Citations:    Fields:    
    28. Liu P, Reed MN, Kotilinek LA, Grant MK, Forster CL, Qiang W, Shapiro SL, Reichl JH, Chiang AC, Jankowsky JL, Wilmot CM, Cleary JP, Zahs KR, Ashe KH. Quaternary Structure Defines a Large Class of Amyloid-? Oligomers Neutralized by Sequestration. Cell Rep. 2015 Jun 23; 11(11):1760-71. PMID: 26051935; PMCID: PMC4494129.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    29. Wang J, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Neul JL, Bedalov A, Pieper AA, Wegener JE, Vingeau S, Reichardt SD, Reichardt HM, G?rtner J, Huppke P. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 May 21; 521(7552):E1-4. PMID: 25993969; PMCID: PMC4684952.
      Citations: 60     Fields:    Translation:AnimalsCells
    30. Yetman MJ, Lillehaug S, Bjaalie JG, Leergaard TB, Jankowsky JL. Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct. 2016 05; 221(4):2231-49. PMID: 25869275; PMCID: PMC4605847.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    31. Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H. NF?B-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease. Neuron. 2015 Jan 07; 85(1):101-115. PMID: 25533482; PMCID: PMC4289109.
      Citations: 188     Fields:    Translation:HumansAnimalsCells
    32. Kim JY, Grunke SD, Levites Y, Golde TE, Jankowsky JL. Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction. J Vis Exp. 2014 Sep 15; (91):51863. PMID: 25286085; PMCID: PMC4199253.
      Citations: 59     Fields:    Translation:AnimalsCells
    33. Tanifum EA, Starosolski ZA, Fowler SW, Jankowsky JL, Annapragada AV. Cerebral vascular leak in a mouse model of amyloid neuropathology. J Cereb Blood Flow Metab. 2014 Oct; 34(10):1646-54. PMID: 25052555; PMCID: PMC4269723.
      Citations: 10     Fields:    Translation:HumansAnimals
    34. Fowler SW, Chiang AC, Savjani RR, Larson ME, Sherman MA, Schuler DR, Cirrito JR, Jankowsky JL, Lesn? SE. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014 Jun 04; 34(23):7871-85. PMID: 24899710; PMCID: PMC4044248.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    35. Zhao R, Fowler SW, Chiang AC, Ji D, Jankowsky JL. Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease. Hippocampus. 2014 Aug; 24(8):963-78. PMID: 24752989; PMCID: PMC4456091.
      Citations: 10     Fields:    Translation:AnimalsCells
    36. Sun MY, Yetman MJ, Lee TC, Chen Y, Jankowsky JL. Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreER(T2) lines. J Comp Neurol. 2014 Apr 01; 522(5):1191-208. PMID: 24519019; PMCID: PMC4047796.
      Citations: 40     Fields:    Translation:AnimalsCells
    37. Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci. 2014 Mar 12; 34(11):3826-40. PMID: 24623762; PMCID: PMC3951689.
      Citations: 78     Fields:    Translation:HumansAnimals
    38. Yetman MJ, Jankowsky JL. Wild-type neural progenitors divide and differentiate normally in an amyloid-rich environment. J Neurosci. 2013 Oct 30; 33(44):17335-41. PMID: 24174666; PMCID: PMC3812504.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    39. Chakrabarty P, Rosario A, Cruz P, Siemienski Z, Ceballos-Diaz C, Crosby K, Jansen K, Borchelt DR, Kim JY, Jankowsky JL, Golde TE, Levites Y. Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. PLoS One. 2013; 8(6):e67680. PMID: 23825679; PMCID: PMC3692458.
      Citations: 85     Fields:    Translation:AnimalsCells
    40. Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. Eur J Neurosci. 2013 Apr; 37(8):1203-20. PMID: 23347239; PMCID: PMC3628093.
      Citations: 67     Fields:    Translation:AnimalsCells
    41. Han HJ, Allen CC, Buchovecky CM, Yetman MJ, Born HA, Marin MA, Rodgers SP, Song BJ, Lu HC, Justice MJ, Probst FJ, Jankowsky JL. Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. J Neurosci. 2012 Aug 01; 32(31):10574-86. PMID: 22855807; PMCID: PMC3431916.
      Citations: 48     Fields:    Translation:Animals
    42. Rodgers SP, Born HA, Das P, Jankowsky JL. Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult. Mol Neurodegener. 2012 Jun 18; 7:28. PMID: 22709352; PMCID: PMC3457908.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    43. Cowin RM, Roscic A, Bui N, Graham D, Paganetti P, Jankowsky JL, Weiss A, Paylor R. Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse. Behav Brain Res. 2012 Apr 15; 229(2):308-19. PMID: 22306231.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    44. Wang A, Das P, Switzer RC, Golde TE, Jankowsky JL. Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy. J Neurosci. 2011 Mar 16; 31(11):4124-36. PMID: 21411653; PMCID: PMC3074951.
      Citations: 59     Fields:    Translation:Animals
    45. Badea A, Johnson GA, Jankowsky JL. Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. Neuroimage. 2010 Apr 01; 50(2):416-27. PMID: 20035883; PMCID: PMC2823970.
      Citations: 21     Fields:    Translation:Animals
    46. Moss FJ, Imoukhuede PI, Scott K, Hu J, Jankowsky JL, Quick MW, Lester HA. GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET. J Gen Physiol. 2009 Dec; 134(6):489-521. PMID: 19948998; PMCID: PMC2806419.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    47. Jankowsky JL, Xu GM, Borchelt DR, Rampon C, Verret L. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. J Neurosci. 2007 Jun 20; 27(25):6771-80. PMID: 17581964; PMCID: PMC4439193.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    48. Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem. 2007 Aug 03; 282(31):22707-20. PMID: 17556372; PMCID: PMC4435736.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    49. Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005 Dec; 2(12):e355. PMID: 16279840; PMCID: PMC1283364.
      Citations: 122     Fields:    Translation:HumansAnimals
    50. Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci. 2005 May 25; 25(21):5217-24. PMID: 15917461; PMCID: PMC4440804.
      Citations: 173     Fields:    Translation:HumansAnimals
    51. Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging. 2004 Aug; 25(7):885-92. PMID: 15212842.
      Citations: 80     Fields:    Translation:HumansAnimals
    52. Jankowsky JL, Xu G, Fromholt D, Gonzales V, Borchelt DR. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2003 Dec; 62(12):1220-7. PMID: 14692698.
      Citations: 93     Fields:    Translation:Animals
    53. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004 Jan 15; 13(2):159-70. PMID: 14645205.
      Citations: 760     Fields:    Translation:HumansAnimalsCells
    54. Jankowsky JL, Savonenko A, Schilling G, Wang J, Xu G, Borchelt DR. Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development. Curr Neurol Neurosci Rep. 2002 Sep; 2(5):457-64. PMID: 12169227.
      Citations: 21     Fields:    Translation:AnimalsCells
    55. Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Hum Mol Genet. 2001 Oct 15; 10(22):2525-37. PMID: 11709540.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    56. Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 2001 Jun; 17(6):157-65. PMID: 11337275.
      Citations: 448     Fields:    Translation:HumansAnimals
    57. Jankowsky JL, Patterson PH. The role of cytokines and growth factors in seizures and their sequelae. Prog Neurobiol. 2001 Feb; 63(2):125-49. PMID: 11124444.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    58. Jankowsky JL, Derrick BE, Patterson PH. Cytokine responses to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques. Learn Mem. 2000 Nov-Dec; 7(6):400-12. PMID: 11112799; PMCID: PMC311345.
      Citations: 38     Fields:    Translation:AnimalsCells
    59. Jankowsky JL, Patterson PH. Cytokine and growth factor involvement in long-term potentiation. Mol Cell Neurosci. 1999 Dec; 14(6):273-86. PMID: 10656258.
      Citations: 8     Fields:    Translation:Animals
    60. Jankowsky JL, Patterson PH. Cytokine and growth factor involvement in long-term potentiation. Mol Cell Neurosci. 1999 Oct-Nov; 14(4-5):273-86. PMID: 10588384.
      Citations: 6     Fields:    Translation:Animals
    61. Jankowsky JL, Patterson PH. Differential regulation of cytokine expression following pilocarpine-induced seizure. Exp Neurol. 1999 Oct; 159(2):333-46. PMID: 10506506.
      Citations: 12     Fields:    Translation:AnimalsCells
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