PRADIP SAHA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biswas J, Saha P, Ganguly J, Paul AK. Production and characterization of a bioactive extracellular homopolysaccharide produced by Haloferax sp. BKW301. J Basic Microbiol. 2020 Oct 06. PMID: 33022819.
      Citations:    Fields:    
    2. Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM. STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. 2020 Sep 29. PMID: 32994273.
      Citations:    Fields:    
    3. Saha PK, Hamilton MP, Rajapakshe K, Putluri V, Felix JB, Masschelin P, Cox AR, Bajaj M, Putluri N, Coarfa C, Hartig SM. miR-30a targets gene networks that promote browning of human and mouse adipocytes. Am J Physiol Endocrinol Metab. 2020 Oct 01; 319(4):E667-E677. PMID: 32799658.
      Citations:    Fields:    
    4. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2076-2083. PMID: 31924743.
      Citations: 2     Fields:    Translation:HumansAnimals
    5. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Coll TF, Richards JS. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 07 02; 5. PMID: 31265437.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 Jan; 1(1):70-85. PMID: 31198906.
      Citations:    
    7. Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. 2018 12; 67(12):2541-2553. PMID: 30002134.
      Citations: 7     Fields:    Translation:Animals
    8. Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR. Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017 Dec; 23(12):1444-1453. PMID: 29106398.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    9. Agarwal N, Iyer D, Gabbi C, Saha P, Patel SG, Mo Q, Chang B, Goswami B, Schubert U, Kopp JB, Lewis DE, Balasubramanyam A. HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRa and PPARa dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017 10 17; 7(1):13362. PMID: 29042644.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD. Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. Hepatology. 2017 08; 66(2):498-509. PMID: 28378930.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH. The constitutive lipid droplet protein PLIN2 regulates autophagy in liver. Autophagy. 2017 Jul 03; 13(7):1130-1144. PMID: 28548876.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. Chen E, Tsai TH, Li L, Saha P, Chan L, Chang BH. PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic ß Cells. Sci Rep. 2017 01 19; 7:40855. PMID: 28102311.
      Citations: 13     Fields:    Translation:AnimalsCells
    13. Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR. Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21; 165(3):566-79. PMID: 27087445.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    14. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425.
      Citations: 15     Fields:    Translation:AnimalsCells
    15. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. PMID: 26081744.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    16. Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-48. PMID: 25953849.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Chen W, Zhou H, Saha P, Li L, Chan L. Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology. 2014 Nov; 155(11):4215-25. PMID: 25093462.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    18. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and ß-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ß-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38. PMID: 23547261.
      Citations: 65     Fields:    Translation:AnimalsCells
    19. Lacaria M, Saha P, Potocki L, Bi W, Yan J, Girirajan S, Burns B, Elsea S, Walz K, Chan L, Lupski JR, Gu W. A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men. PLoS Genet. 2012; 8(5):e1002713. PMID: 22654670.
      Citations: 23     Fields:    Translation:HumansAnimals
    20. Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, Wen S, Tian M, Ma J, Kolonin MG, Saha PK, Do KA, Hulvat JF, Gelovani JG, Chan L, Arap W, Pasqualini R. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011 Nov 09; 3(108):108ra112. PMID: 22072637.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    21. Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell. 2011 Dec; 10(6):996-1010. PMID: 21895961.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    22. Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab. 2011 Jan 05; 13(1):35-43. PMID: 21195347.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    23. Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab. 2010 Dec 01; 12(6):606-18. PMID: 21109193.
      Citations: 30     Fields:    Translation:AnimalsCells
    24. Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J Biol Chem. 2010 Dec 24; 285(52):40581-92. PMID: 20956520.
      Citations: 36     Fields:    Translation:AnimalsCells
    25. Chang BH, Li L, Saha P, Chan L. Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J Lipid Res. 2010 Aug; 51(8):2132-42. PMID: 20424269.
      Citations: 36     Fields:    Translation:AnimalsCells
    26. Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 07; 395(3):395-400. PMID: 20382127.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    27. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18831-6. PMID: 19850873.
      Citations: 95     Fields:    Translation:AnimalsCells
    28. Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 2009 Jan 07; 9(1):77-87. PMID: 19117548.
      Citations: 47     Fields:    Translation:AnimalsCells
    29. Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19229-34. PMID: 19047629.
      Citations: 80     Fields:    Translation:AnimalsCells
    30. Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28; 322(5906):1395-9. PMID: 19039140.
      Citations: 93     Fields:    Translation:AnimalsCells
    31. Gupta S, Saha PK, Mukhopadhyay A. Prevalence of hypothyroidism and importance of cholesterol estimation in patients suffering from major depressive disorder. J Indian Med Assoc. 2008 Apr; 106(4):240, 242. PMID: 18828343.
      Citations: 3     Fields:    Translation:Humans
    32. Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology. 2007 Jul; 46(1):147-57. PMID: 17526026.
      Citations: 67     Fields:    Translation:AnimalsCells
    33. De J, Mukhopadhyay A, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Biochem. 2006 Sep; 21(2):165-8. PMID: 23105637.
      Citations:    
    34. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2006 Nov; 20(11):2671-81. PMID: 16803864.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    35. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 2006 May; 3(5):379-86. PMID: 16679295.
      Citations: 106     Fields:    Translation:AnimalsCells
    36. Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr; 116(4):1102-9. PMID: 16557297.
      Citations: 222     Fields:    Translation:AnimalsCells
    37. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005 Oct; 2(4):227-38. PMID: 16213225.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    38. Saha PK, Kojima H, Martinez-Botas J, Sunehag AL, Chan L. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem. 2004 Aug 20; 279(34):35150-8. PMID: 15197189.
      Citations: 48     Fields:    Translation:AnimalsCells
    39. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004 Jun; 10(6):625-32. PMID: 15133506.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    40. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74. PMID: 14578284.
      Citations: 23     Fields:    Translation:AnimalsCells
    41. Sharma SK, Balamurugan A, Saha PK, Pandey RM, Mehra NK. Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med. 2002 Oct 01; 166(7):916-9. PMID: 12359646.
      Citations: 66     Fields:    Translation:HumansCTClinical Trials
    42. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH, Paul A, Chan L. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20; 277(38):34658-61. PMID: 12151381.
      Citations: 98     Fields:    Translation:AnimalsCells
    43. Guhathakurta B, Sasmal D, Ghosh AN, Kumar R, Saha P, Biswas D, Khetawat D, Datta A. Adhesion and invasion of a mutant Shigella flexneri to an eukaryotic cell line in absence of the 220-kb virulence plasmid. FEMS Microbiol Lett. 1999 Dec 15; 181(2):267-75. PMID: 10585548.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    44. Basu I, Mitra R, Saha PK, Ghosh AN, Bhattacharya J, Chakrabarti MK, Takeda Y, Nair GB. Morphological and cytoskeletal changes caused by non-membrane damaging cytotoxin of Vibrio cholerae on int 407 and HeLa cells. FEMS Microbiol Lett. 1999 Oct 15; 179(2):255-63. PMID: 10518724.
      Citations: 3     Fields:    Translation:HumansCells
    45. Pal A, Saha PK, Nair GB, Yamasaki S, Takeda T, Takeda Y, Bhattacharya SK, Ramamurthy T. Clonal analysis of non-toxigenic Vibrio cholerae O1 associated with an outbreak of cholera. Indian J Med Res. 1999 Jun; 109:208-11. PMID: 10491912.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    46. Koley H, Mitra R, Basu A, Mukhopadhyay AK, Saha PK, Ramakrishna BS, Krishnan S, Takeda Y, Nair GB. Response of wild-type mutants of Vibrio cholerae O1 possessing different combinations of virulence genes in the ligated rabbit ileal loop and in Ussing chambers: evidence for the presence of additional secretogen. J Med Microbiol. 1999 Jan; 48(1):51-57. PMID: 9920125.
      Citations: 6     Fields:    Translation:AnimalsCells
    47. Mitra R, Saha PK, Basu I, Venkataraman A, Ramakrishna BS, Albert MJ, Takeda Y, Nair GB. Characterization of non-membrane-damaging cytotoxin of non-toxigenic Vibrio cholerae O1 and its relevance to disease. FEMS Microbiol Lett. 1998 Dec 15; 169(2):331-9. PMID: 9868778.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    48. Saha PK, Nair GB. Production of monoclonal antibodies to the non-membrane-damaging cytotoxin (NMDCY) purified from Vibrio cholerae O26 and distribution of NMDCY among strains of Vibrio cholerae and other enteric bacteria determined by monoclonal-polyclonal sandwich enzyme-linked immunosorbent assay. Infect Immun. 1997 Feb; 65(2):801-5. PMID: 9009346.
      Citations: 2     Fields:    Translation:AnimalsCells
    49. Saha PK, Koley H, Nair GB. Purification and characterization of an extracellular secretogenic non-membrane-damaging cytotoxin produced by clinical strains of Vibrio cholerae non-O1. Infect Immun. 1996 Aug; 64(8):3101-8. PMID: 8757840.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    50. Mukhopadhyay AK, Garg S, Saha PK, Takeda Y, Bhattacharya SK, Nair GB. Comparative analysis of factors promoting optimal production of cholera toxin by Vibrio cholerae O1 (classical & E1Tor biotypes) & O139. Indian J Med Res. 1996 Jul; 104:129-33. PMID: 8783515.
      Citations:    Fields:    Translation:Cells
    51. Mukhopadhyay AK, Saha PK, Garg S, Bhattacharya SK, Shimada T, Takeda T, Takeda Y, Nair GB. Distribution and virulence of Vibrio cholerae belonging to serogroups other than O1 and O139: a nationwide survey. Epidemiol Infect. 1995 Feb; 114(1):65-70. PMID: 7867744.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    52. Garg S, Saha PK, Ramamurthy T, Deb BC, Nair GB, Shimada T, Takeda Y. Nationwide prevalence of the new epidemic strain of Vibrio cholerae O139 Bengal in India. J Infect. 1993 Jul; 27(1):108-9. PMID: 8370938.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    53. Bhattacharya SK, Bhattacharya MK, Nair GB, Dutta D, Deb A, Ramamurthy T, Garg S, Saha PK, Dutta P, Moitra A, et al. Clinical profile of acute diarrhoea cases infected with the new epidemic strain of Vibrio cholerae O139: designation of the disease as cholera. J Infect. 1993 Jul; 27(1):11-5. PMID: 8370939.
      Citations: 20     Fields:    Translation:HumansCellsPHPublic Health
    54. Bhattacharya MK, Bhattacharya SK, Garg S, Saha PK, Dutta D, Nair GB, Deb BC, Das KP. Outbreak of Vibrio cholerae non-O1 in India and Bangladesh. Lancet. 1993 May 22; 341(8856):1346-7. PMID: 8098474.
      Citations: 53     Fields:    Translation:HumansCellsPHPublic Health
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