"Receptor, Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
| Descriptor ID |
D011972
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.200 D12.776.543.750.630.484 D12.776.543.750.750.580.300
|
| Concept/Terms |
Receptor, Insulin- Receptor, Insulin
- Receptors, Insulin
- Insulin Receptors
- Insulin Receptor Protein-Tyrosine Kinase
- Insulin Receptor Protein Tyrosine Kinase
- Insulin Receptor
- Insulin-Dependent Tyrosine Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Insulin".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Insulin".
This graph shows the total number of publications written about "Receptor, Insulin" by people in this website by year, and whether "Receptor, Insulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 1 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 2 | 1 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 1 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 2 | 2 |
| 2026 | 0 | 2 | 2 |
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Below are the most recent publications written about "Receptor, Insulin" by people in Profiles.
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Heparin Increases Food Intake through AgRP Neurons. Cell Rep. 2017 Sep 05; 20(10):2455-2467.
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Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas. Mol Cancer Ther. 2017 04; 16(4):705-716.
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Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring. Biol Reprod. 2016 Jan; 94(1):5.
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Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring. Endocrinology. 2014 Aug; 155(8):3036-46.
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Acute psychological stress results in the rapid development of insulin resistance. J Endocrinol. 2013 May; 217(2):175-84.
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Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer. Cancer. 2012 May 01; 118(9):2454-65.
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A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res. 2011 Nov 01; 71(21):6773-84.
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High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clin Cancer Res. 2011 Apr 15; 17(8):2314-27.
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Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 2010 Feb; 151(2):741-7.
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Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations. Placenta. 2009 Aug; 30(8):693-9.