CASP8 and FADD-Like Apoptosis Regulating Protein
"CASP8 and FADD-Like Apoptosis Regulating Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
| Descriptor ID |
D053446
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| MeSH Number(s) |
D12.644.360.024.285.024 D12.644.360.024.500.024 D12.644.360.075.421.024 D12.776.157.057.018.024 D12.776.476.075.421.024
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "CASP8 and FADD-Like Apoptosis Regulating Protein".
Below are MeSH descriptors whose meaning is more specific than "CASP8 and FADD-Like Apoptosis Regulating Protein".
This graph shows the total number of publications written about "CASP8 and FADD-Like Apoptosis Regulating Protein" by people in this website by year, and whether "CASP8 and FADD-Like Apoptosis Regulating Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "CASP8 and FADD-Like Apoptosis Regulating Protein" by people in Profiles.
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Receptor tyrosine kinase recepteur d'origine nantais as predictive marker for aggressive prostate cancer in African Americans. Mol Carcinog. 2019 06; 58(6):854-861.
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Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis. J Biol Chem. 2018 12 28; 293(52):20062-20072.
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Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS One. 2015; 10(3):e0117994.
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Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10. Cancer Res. 2015 Apr 15; 75(8):1668-74.
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Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013 Oct 24; 155(3):552-66.
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The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May; 13(4):411-22.
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Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. Pediatr Blood Cancer. 2013 Apr; 60(4):575-9.
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Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence. PLoS One. 2012; 7(9):e44917.
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Antiviral protection against enterovirus 71 mediated by autophagy induction following FLICE-inhibitory protein inactivation. Virus Res. 2012 Oct; 169(1):316-20.
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MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts. Cell Death Dis. 2012 Aug 09; 3:e369.