"Hydrolases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
Descriptor ID |
D006867
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MeSH Number(s) |
D08.811.277
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hydrolases".
Below are MeSH descriptors whose meaning is more specific than "Hydrolases".
This graph shows the total number of publications written about "Hydrolases" by people in this website by year, and whether "Hydrolases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
1996 | 1 | 0 | 1 |
1997 | 1 | 0 | 1 |
1998 | 1 | 1 | 2 |
1999 | 0 | 1 | 1 |
2000 | 1 | 0 | 1 |
2001 | 0 | 1 | 1 |
2002 | 1 | 1 | 2 |
2003 | 1 | 1 | 2 |
2004 | 3 | 0 | 3 |
2005 | 2 | 1 | 3 |
2006 | 0 | 1 | 1 |
2007 | 4 | 3 | 7 |
2008 | 1 | 2 | 3 |
2009 | 1 | 1 | 2 |
2010 | 5 | 2 | 7 |
2011 | 3 | 1 | 4 |
2012 | 7 | 0 | 7 |
2013 | 2 | 2 | 4 |
2014 | 4 | 1 | 5 |
2015 | 4 | 0 | 4 |
2016 | 1 | 4 | 5 |
2017 | 1 | 0 | 1 |
2018 | 0 | 2 | 2 |
2019 | 1 | 0 | 1 |
2021 | 3 | 2 | 5 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hydrolases" by people in Profiles.
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Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. Nat Commun. 2023 07 03; 14(1):3911.
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Phase 1 trial of ADI-PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors. Cancer Med. 2022 01; 11(2):340-347.
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Enhancing the Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Signaling and Arginine Deprivation in Melanoma. Int J Mol Sci. 2021 Jul 16; 22(14).
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Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers. Oncoimmunology. 2021; 10(1):1943253.
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Phase 1 trial of ADI-PEG20 plus cisplatin in patients with pretreated metastatic melanoma or other advanced solid malignancies. Br J Cancer. 2021 04; 124(9):1533-1539.
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Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs. Am J Physiol Endocrinol Metab. 2021 03 01; 320(3):E641-E652.
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Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation. Mol Cancer Ther. 2019 12; 18(12):2381-2393.
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Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. J Exp Med. 2019 01 07; 216(1):176-194.
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The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge. J Nutr. 2018 06 01; 148(6):844-850.
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A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients. Sci Rep. 2017 09 12; 7(1):11253.