"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 10 | 0 | 10 |
| 1995 | 13 | 0 | 13 |
| 1996 | 7 | 1 | 8 |
| 1997 | 10 | 0 | 10 |
| 1998 | 8 | 2 | 10 |
| 1999 | 5 | 0 | 5 |
| 2000 | 2 | 2 | 4 |
| 2001 | 1 | 1 | 2 |
| 2002 | 3 | 1 | 4 |
| 2003 | 2 | 1 | 3 |
| 2004 | 1 | 0 | 1 |
| 2005 | 7 | 2 | 9 |
| 2006 | 2 | 3 | 5 |
| 2007 | 2 | 2 | 4 |
| 2008 | 4 | 0 | 4 |
| 2009 | 4 | 1 | 5 |
| 2010 | 1 | 2 | 3 |
| 2011 | 1 | 0 | 1 |
| 2012 | 6 | 2 | 8 |
| 2013 | 5 | 0 | 5 |
| 2014 | 6 | 5 | 11 |
| 2015 | 4 | 3 | 7 |
| 2016 | 5 | 0 | 5 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 1 | 2 |
| 2021 | 5 | 1 | 6 |
| 2022 | 5 | 1 | 6 |
| 2023 | 2 | 0 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Med. 2024 Feb; 13(3):e7019.
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Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. Int J Neuropsychopharmacol. 2023 09 25; 26(9):627-638.
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Promoter region variant C-824T in the TH gene modulates the subjective effects of cocaine. Am J Addict. 2023 09; 32(5):506-509.
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Opioid-stimulant trends in overdose toxicology by race, ethnicity, & gender: An analysis in Delaware, 2013-2019. J Ethn Subst Abuse. 2024 Jul-Sep; 23(3):471-500.
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Cross-sectional examination of ultra-processed food consumption and adverse mental health symptoms. Public Health Nutr. 2022 11; 25(11):3225-3234.
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Substance Use and Performance of Toxicology Screens in the Greater Cincinnati Northern Kentucky Stroke Study. Stroke. 2022 10; 53(10):3082-3090.
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Disparities in Mental Health and Health Risk Behaviors for LGBT Veteran Subgroups in a National U.S. Survey. LGBT Health. 2022 11; 9(8):543-554.
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Positive Allosteric Modulation of mGlu1 Reverses Cocaine-Induced Behavioral and Synaptic Plasticity Through the Integrated Stress Response and Oligophrenin-1. Biol Psychiatry. 2022 12 01; 92(11):871-879.
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Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene. Eur J Clin Pharmacol. 2022 Jun; 78(6):965-973.
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Pharmacogenetics of Addiction Therapy. Methods Mol Biol. 2022; 2547:437-490.