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LOZANO, GUILLERMINA

One or more keywords matched the following items that are connected to LOZANO, GUILLERMINA

Item Type	Name
Academic Article	Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice.
Academic Article	p53 sends nucleotides to repair DNA.
Academic Article	p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas.
Academic Article	A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Academic Article	Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
Academic Article	MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis.
Academic Article	p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation.
Academic Article	Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.
Academic Article	The cenpB gene is not essential in mice.
Academic Article	An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
Academic Article	Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Concept	14-3-3 Proteins
Concept	Ribosomal Proteins
Concept	Oncogene Proteins, Viral
Concept	Adaptor Proteins, Signal Transducing
Concept	Proto-Oncogene Proteins c-myc
Concept	Adenovirus E1A Proteins
Concept	DNA-Binding Proteins
Concept	Oncogene Proteins, Fusion
Concept	Chromosomal Proteins, Non-Histone
Concept	Carrier Proteins
Concept	Proto-Oncogene Proteins c-bcl-2
Concept	Oncogene Proteins
Concept	Cell Cycle Proteins
Concept	Co-Repressor Proteins
Concept	ras Proteins
Concept	Recombinant Fusion Proteins
Concept	Fungal Proteins
Concept	Saccharomyces cerevisiae Proteins
Concept	Son of Sevenless Proteins
Concept	High Mobility Group Proteins
Concept	Nuclear Proteins
Concept	Recombinant Proteins
Concept	Proto-Oncogene Proteins c-jun
Concept	Neoplasm Proteins
Concept	Caenorhabditis elegans Proteins
Concept	Wnt Proteins
Concept	Proto-Oncogene Proteins p21(ras)
Concept	Mutant Proteins
Concept	Shc Signaling Adaptor Proteins
Concept	Smad Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	Proto-Oncogene Proteins c-mdm2
Concept	Proto-Oncogene Proteins c-met
Concept	Apoptosis Regulatory Proteins
Concept	Proto-Oncogene Proteins
Concept	Tumor Suppressor Proteins
Concept	Viral Proteins
Concept	Repressor Proteins
Concept	Proto-Oncogene Proteins c-kit
Concept	Proto-Oncogene Proteins c-akt
Concept	Proteins
Concept	Zebrafish Proteins
Academic Article	Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.
Academic Article	SV40 T antigen abrogates p53-mediated transcriptional activity.
Academic Article	Bcl-2 inhibits p53 nuclear import following DNA damage.
Academic Article	Isolation of the Aspergillus nidulans sudD gene and its human homologue.
Academic Article	The loss of mdm2 induces p53-mediated apoptosis.
Academic Article	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
Academic Article	Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Academic Article	Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Academic Article	Model predictions of MDM2 mediated cell regulation.
Academic Article	Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
Academic Article	Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.
Academic Article	Crippling p53 activities via knock-in mutations in mouse models.
Academic Article	Mdm2-mediated ubiquitylation: p53 and beyond.
Academic Article	Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Academic Article	Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation.
Academic Article	The p53 family grows old.
Academic Article	Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner.
Academic Article	Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.
Academic Article	Structural and functional analysis of p53: the acidic activation domain has transforming capability.
Academic Article	PML, a growth suppressor disrupted in acute promyelocytic leukemia.
Academic Article	The organization and expression of the mdm2 gene.
Academic Article	mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts.
Academic Article	Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Academic Article	Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest.
Academic Article	MDM2 function.
Academic Article	Overproduction of MDM2 in vivo disrupts S phase independent of E2F1.
Academic Article	Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
Academic Article	Organization, expression, and localization of the murine mdmx gene and pseudogene.
Academic Article	An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2.
Academic Article	Disrupting TP53 in mouse models of human cancers.
Academic Article	p21 stability: linking chaperones to a cell cycle checkpoint.
Academic Article	Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.
Academic Article	p21 delays tumor onset by preservation of chromosomal stability.
Academic Article	Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.
Academic Article	High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.
Academic Article	The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival.
Academic Article	EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.
Academic Article	p53 and MDM2: antagonists or partners in crime?
Academic Article	Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities.
Academic Article	Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.
Academic Article	Multiple stress signals activate mutant p53 in vivo.
Academic Article	Che-ating death: CHE1/AATF protects from p53-mediated apoptosis.
Academic Article	Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.
Academic Article	DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-?-driven epithelial-mesenchymal transition.
Academic Article	The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.
Academic Article	USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Academic Article	A convenient cloning vector containing the GAL4 DNA-binding domain.
Academic Article	Inhibition of the mutant p53 gene in transformation assays.
Academic Article	Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences.
Academic Article	Analysis of p53 mutants for transcriptional activity.
Academic Article	Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53.
Academic Article	Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
Academic Article	Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality.
Academic Article	Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation.
Academic Article	p53-independent functions of the p19(ARF) tumor suppressor.
Academic Article	cDNA library screening using the SOS recruitment system.
Academic Article	Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Academic Article	Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies.
Academic Article	Conditional allele of mdm2 which encodes a p53 inhibitor.
Academic Article	The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells.
Academic Article	Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.
Academic Article	A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Academic Article	Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
Academic Article	Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
Academic Article	Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.
Academic Article	Distinct roles of Mdm2 and Mdm4 in red cell production.
Academic Article	The oncogenic roles of p53 mutants in mouse models.
Academic Article	Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.
Academic Article	Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.
Academic Article	Mtbp haploinsufficiency in mice increases tumor metastasis.
Academic Article	The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Academic Article	Mdm2 and Mdm4 loss regulates distinct p53 activities.
Academic Article	p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner.
Academic Article	A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
Academic Article	Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.
Academic Article	A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Academic Article	Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.
Academic Article	Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-? (TGF-?).
Academic Article	Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop.
Academic Article	Limiting the power of p53 through the ubiquitin proteasome pathway.
Academic Article	An intron binding protein is required for transformation ability of p53.
Academic Article	Cyclin E restores p53 activity in contact-inhibited cells.
Academic Article	The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo.
Academic Article	Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice.
Academic Article	Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.
Academic Article	RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties.
Academic Article	MDM2, an introduction.
Academic Article	Gankyrin: an intriguing name for a novel regulator of p53 and RB.
Academic Article	The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development.
Academic Article	Building p53.
Academic Article	The ups and downs of p53 regulation in hematopoietic stem cells.
Academic Article	ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.
Academic Article	The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.
Academic Article	Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice.
Academic Article	Mutation of phosphoserine 389 affects p53 function in vivo.
Academic Article	14-3-3 sigma positively regulates p53 and suppresses tumor growth.
Academic Article	What have animal models taught us about the p53 pathway?
Academic Article	Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Academic Article	HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.
Academic Article	p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis.
Academic Article	Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.
Academic Article	Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Academic Article	Tissue-specific and age-dependent effects of global Mdm2 loss.
Academic Article	Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.
Academic Article	Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity.
Academic Article	Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Academic Article	TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.
Academic Article	Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma.
Academic Article	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.
Academic Article	p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.
Academic Article	MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Academic Article	Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations.
Academic Article	Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.
Academic Article	Distinct downstream targets manifest p53-dependent pathologies in mice.
Academic Article	Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End.
Academic Article	The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.
Academic Article	The Enigma of p53.
Academic Article	Mdm proteins: critical regulators of embry ogenesis and homeostasis.
Academic Article	Tumorigenesis promotes Mdm4-S overexpression.
Academic Article	Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.
Academic Article	Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.
Academic Article	Daxx Functions Are p53-Independent In Vivo.
Academic Article	Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.
Concept	Tripartite Motif Proteins
Concept	Ataxia Telangiectasia Mutated Proteins
Academic Article	Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity.
Academic Article	Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress.
Academic Article	Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Academic Article	p53 tetramerization: at the center of the dominant-negative effect of mutant p53.
Academic Article	p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo.
Academic Article	MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.
Academic Article	Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis.
Academic Article	Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
Academic Article	Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo.
Academic Article	Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas.
Academic Article	Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling.
Academic Article	The histone chaperone function of Daxx is dispensable for embryonic development.

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