Son of Sevenless Proteins
"Son of Sevenless Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS that are genetically related to the Son of Sevenless gene from DROSOPHILA. Sevenless refers to genetic mutations in DROSOPHILA that cause loss of the R7 photoreceptor which is required to see UV light.
| Descriptor ID |
D020664
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| MeSH Number(s) |
D12.644.360.325.300.700.700 D12.776.476.325.300.700.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Son of Sevenless Proteins".
Below are MeSH descriptors whose meaning is more specific than "Son of Sevenless Proteins".
This graph shows the total number of publications written about "Son of Sevenless Proteins" by people in this website by year, and whether "Son of Sevenless Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 2 | 0 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Son of Sevenless Proteins" by people in Profiles.
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SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017 Mar; 28(3):981-994.
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Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun. 2015 Jun 24; 6:7354.
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CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. Gene. 2005 Oct 10; 359:119-26.
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Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins. Biochemistry. 2004 Aug 03; 43(30):9790-9.
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Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation. Biochemistry. 2004 Jun 22; 43(24):7787-97.
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The effect of the polyproline II (PPII) conformation on the denatured state entropy. Protein Sci. 2003 Mar; 12(3):447-57.
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Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes. Blood. 2001 Sep 15; 98(6):1773-81.
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cDNA library screening using the SOS recruitment system. Biotechniques. 2001 Jan; 30(1):94-8, 100.
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Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. Genomics. 1993 Oct; 18(1):14-9.