Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
|
| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
|
| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Actilyse- Actilyse
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
|
Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2001 | 3 | 4 | 7 |
| 2004 | 0 | 1 | 1 |
| 2005 | 3 | 0 | 3 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 5 | 0 | 5 |
| 2013 | 6 | 2 | 8 |
| 2014 | 3 | 1 | 4 |
| 2015 | 5 | 2 | 7 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 5 | 2 | 7 |
| 2019 | 3 | 3 | 6 |
| 2020 | 4 | 2 | 6 |
| 2021 | 2 | 3 | 5 |
| 2022 | 1 | 5 | 6 |
| 2023 | 0 | 3 | 3 |
| 2024 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Emergency Physician Versus Telemedicine Neurologist Assessment for Thrombolytic Indication in the Treatment of Acute Ischemic Stroke (AIS). Acad Emerg Med. 2026 Jan; 33(1):e70096.
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Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis. J Neurointerv Surg. 2025 Jun 01; 17(e2):e261-e268.
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Histotripsy and Catheter-Directed Lytic: Efficacy in Highly Retracted Porcine Clots In Vitro. Ultrasound Med Biol. 2024 08; 50(8):1167-1177.
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Strokes Averted by Intravenous Thrombolysis: A Secondary Analysis of a Prospective, Multicenter, Controlled Trial of Mobile Stroke Units. Ann Neurol. 2024 Feb; 95(2):347-361.
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Outcomes of patients with pre-existing disability managed by mobile stroke units: A sub-analysis of the BEST-MSU study. Int J Stroke. 2023 12; 18(10):1209-1218.
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Complications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Stroke. 2023 05; 54(5):1192-1204.
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Association of Heparin-Like Effect, Factor VII/XIII Deficiency and?Fibrinolysis with Rebleeding Risk in Cirrhosis with Acute Variceal Bleeding. Dig Dis Sci. 2023 02; 68(2):497-513.
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Tissue plasminogen activator in left ventricular assist device-related intravascular hemolysis after failed augmented anticoagulation. Int J Artif Organs. 2022 Nov; 45(11):911-918.
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Thrombolysis Experience in Costa Rica Compared Against Individual Patient Data from two Randomized Controlled Trials. J Stroke Cerebrovasc Dis. 2022 Aug; 31(8):106599.
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Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility. Ultrasound Med Biol. 2022 08; 48(8):1567-1578.