"Prothrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
| Descriptor ID |
D011516
|
| MeSH Number(s) |
D08.622.709 D12.776.124.125.800 D23.119.945
|
| Concept/Terms |
Prothrombin- Prothrombin
- Factor II
- Blood Coagulation Factor II
- Differentiation Reversal Factor
- Factor, Differentiation Reversal
- Coagulation Factor II
- Factor II, Coagulation
- II, Coagulation Factor
|
Below are MeSH descriptors whose meaning is more general than "Prothrombin".
Below are MeSH descriptors whose meaning is more specific than "Prothrombin".
This graph shows the total number of publications written about "Prothrombin" by people in this website by year, and whether "Prothrombin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 1 | 0 | 1 |
| 2004 | 1 | 2 | 3 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prothrombin" by people in Profiles.
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National Liver Cancer Screening Trial (TRACER) study protocol. Hepatol Commun. 2024 Nov 01; 8(11).
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The Performance of AFP, AFP-3, DCP as Biomarkers for Detection of Hepatocellular Carcinoma (HCC): A Phase 3 Biomarker Study in the United States. Clin Gastroenterol Hepatol. 2023 02; 21(2):415-423.e4.
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GALAD demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis. Hepatology. 2022 03; 75(3):541-549.
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Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation. Sci Rep. 2021 11 08; 11(1):21852.
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Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts. Sci Rep. 2020 02 06; 10(1):2005.
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Does a dose relationship exist with prothrombin complex and factor Xa inhibitor reversal? An alternate perspective of Yohe et al. Am J Emerg Med. 2020 03; 38(3):686-687.
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Rationale and design of the Hepatocellular carcinoma Early Detection Strategy study: A multi-center longitudinal initiative of the National Cancer Institute's Early Detection Research Network. Contemp Clin Trials. 2019 01; 76:49-54.
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PIVKA-II correlates with INR but not protein C or protein S concentrations in cord blood among newborns. J Neonatal Perinatal Med. 2016 May 18; 9(2):139-43.
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Short-term venous stasis induces fibrinolytic activation but not thrombin formation. J Atheroscler Thromb. 2014; 21(12):1260-70.
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Normal saline influences coagulation and endothelial function after traumatic brain injury and hemorrhagic shock in pigs. Surgery. 2014 Sep; 156(3):556-63.