Urokinase-Type Plasminogen Activator
"Urokinase-Type Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
| Descriptor ID |
D014568
|
| MeSH Number(s) |
D08.811.277.656.300.760.910 D08.811.277.656.959.350.910 D12.776.124.125.662.884
|
| Concept/Terms |
Urokinase-Type Plasminogen Activator- Urokinase-Type Plasminogen Activator
- Urokinase Type Plasminogen Activator
- Plasminogen Activator, Urokinase-Type
- U-Plasminogen Activator
- U Plasminogen Activator
- U-PA
- Urinary Plasminogen Activator
- Urokinase
|
Below are MeSH descriptors whose meaning is more general than "Urokinase-Type Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Urokinase-Type Plasminogen Activator".
This graph shows the total number of publications written about "Urokinase-Type Plasminogen Activator" by people in this website by year, and whether "Urokinase-Type Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1997 | 1 | 0 | 1 |
| 1998 | 3 | 1 | 4 |
| 1999 | 0 | 2 | 2 |
| 2000 | 2 | 2 | 4 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 1 | 3 |
| 2005 | 1 | 2 | 3 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Urokinase-Type Plasminogen Activator" by people in Profiles.
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Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease. Mol Ther. 2025 Mar 05; 33(3):917-932.
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Pravastatin Protects Cytotrophoblasts from Hyperglycemia-Induced Preeclampsia Phenotype. Cells. 2024 09 13; 13(18).
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Exploring the angiographic-biologic phenotype in the IMAGINE study: quantitative UWFA and cytokine expression. Br J Ophthalmol. 2022 10; 106(10):1444-1449.
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Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med. 2020 01 30; 382(5):416-426.
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p63-Mediated activation of the ?-catenin/c-Myc signaling pathway stimulates esophageal squamous carcinoma cell invasion and metastasis. Cancer Lett. 2014 Oct 10; 353(1):124-32.
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Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-?B Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells. PLoS One. 2013; 8(12):e82282.
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Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. Am J Pathol. 2013 Oct; 183(4):1306-17.
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MicroRNA-146a suppresses metastatic activity in brain metastasis. Mol Cells. 2012 Sep; 34(3):329-34.
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A multiplicity of anti-invasive effects of farnesyl transferase inhibitor SCH66336 in human head and neck cancer. Int J Cancer. 2012 Aug 01; 131(3):537-47.
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A fibrin-specific thrombolytic nanomedicine approach to acute ischemic stroke. Nanomedicine (Lond). 2011 Jun; 6(4):605-15.