"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
| Descriptor ID |
D053804
|
| MeSH Number(s) |
D08.811.277.656.300.760.397 D08.811.277.656.959.350.397
|
| Concept/Terms |
Granzyme K- Granzyme K
- Natural Killer Cell Granule Tryptase-2
- Natural Killer Cell Granule Tryptase 2
- NK-Tryptase-2
- NK Tryptase 2
- Granzyme-3
- Granzyme 3
Granzyme A- Granzyme A
- Cytotoxic T-Lymphocyte Proteinase 1
- Cytotoxic T Lymphocyte Proteinase 1
- Hanukah Factor
Granzyme B- Granzyme B
- Fragmentin 2
- Cytotoxic T-Lymphocyte Associated 1 Protein
- Cytotoxic T Lymphocyte Associated 1 Protein
- Granzyme-Like Protein III
- Granzyme Like Protein III
- Cytotoxic Serine Protease B
|
Below are MeSH descriptors whose meaning is more general than "Granzymes".
Below are MeSH descriptors whose meaning is more specific than "Granzymes".
This graph shows the total number of publications written about "Granzymes" by people in this website by year, and whether "Granzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 5 | 5 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 3 | 3 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Granzymes" by people in Profiles.
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Human HKU1-Reactive CD4 T Cells Are Enriched for Cytolytic Potential That Persists in Older Adults. J Infect Dis. 2025 Jul 11; 231(6):1591-1596.
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BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy. Cancer Immunol Res. 2022 05 03; 10(5):597-611.
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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection. Immunity. 2019 12 17; 51(6):1043-1058.e4.
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IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy. J Immunol. 2018 10 01; 201(7):2141-2153.
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Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control. JCI Insight. 2017 12 07; 2(23).
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Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy. J Infect Dis. 2017 09 15; 216(6):678-687.
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Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. Am J Respir Crit Care Med. 2017 08 15; 196(4):494-501.
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Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. Crit Care Med. 2016 Nov; 44(11):2010-2017.
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Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. Crit Care Med. 2016 10; 44(10):e1000-3.
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Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. J Autoimmun. 2016 08; 72:8-18.