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An integrin ?3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
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An integrin ?3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
An integrin ?3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68.
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PubMed
subject areas
Animals
Cell Line, Tumor
Cell Proliferation
Clinical Trials, Phase II as Topic
Drug Resistance, Neoplasm
ErbB Receptors
Erlotinib Hydrochloride
Female
Humans
Integrin alphaVbeta3
Integrin beta3
Lung Neoplasms
Mice
Mice, Inbred NOD
Mice, Nude
Mice, SCID
Molecular Targeted Therapy
Neoplastic Stem Cells
Phenotype
Protein Kinase Inhibitors
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-rel
Proto-Oncogene Proteins p21(ras)
Quinazolines
ral GTP-Binding Proteins
Randomized Controlled Trials as Topic
ras Proteins
RNA Interference
Signal Transduction
Spheroids, Cellular
Time Factors
Transfection
Tumor Burden
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
authors with profiles
JING WANG
IGNACIO IVAN WISTUBA
JOHN VICTOR HEYMACH