"Spheroids, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
| Descriptor ID |
D018874
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| MeSH Number(s) |
A11.251.800
|
| Concept/Terms |
Spheroids, Cellular- Spheroids, Cellular
- Cellular Spheroid
- Cellular Spheroids
- Spheroid, Cellular
- Multicellular Spheroids
- Multicellular Spheroid
- Spheroid, Multicellular
- Spheroids, Multicellular
|
Below are MeSH descriptors whose meaning is more general than "Spheroids, Cellular".
Below are MeSH descriptors whose meaning is more specific than "Spheroids, Cellular".
This graph shows the total number of publications written about "Spheroids, Cellular" by people in this website by year, and whether "Spheroids, Cellular" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 1 | 4 | 5 |
| 2015 | 0 | 3 | 3 |
| 2016 | 1 | 2 | 3 |
| 2017 | 1 | 3 | 4 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spheroids, Cellular" by people in Profiles.
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Insights into spheroid formation: interaction of ovarian cancer cells with macrophage populations in the tumor microenvironment. J Transl Med. 2025 Oct 29; 23(1):1192.
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Development of Novel 3D Spheroids for Discrete Subaortic Stenosis. Cardiovasc Eng Technol. 2024 Dec; 15(6):704-715.
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Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. J Cell Biol. 2022 02 09; 221(4).
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Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition. Nat Commun. 2021 05 03; 12(1):2498.
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Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Nat Commun. 2021 04 22; 12(1):2369.
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Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients. EMBO Mol Med. 2020 08 07; 12(8):e12697.
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TFEB regulates murine liver cell fate during development and regeneration. Nat Commun. 2020 05 18; 11(1):2461.
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Shape Effect of Nanoparticles on Tumor Penetration in Monolayers Versus Spheroids. Mol Pharm. 2019 07 01; 16(7):2902-2911.
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Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019; 8(2):209-229.
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Designing nanoparticles with improved tumor penetration: surface properties from the molecular architecture viewpoint. J Mater Chem B. 2019 02 14; 7(6):953-964.