beta-Lactamase Inhibitors

"beta-Lactamase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES.

Descriptor ID	D065093
MeSH Number(s)	D27.505.519.389.400 D27.505.954.122.085.516
Concept/Terms	beta-Lactamase Inhibitors beta-Lactamase Inhibitors Inhibitors, beta-Lactamase beta Lactamase Inhibitors Inhibitors, beta Lactamase Lactamase Inhibitors, beta beta Lactamase Antagonists Antagonists, beta Lactamase Lactamase Antagonists, beta

Below are MeSH descriptors whose meaning is more general than "beta-Lactamase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
beta-Lactamase Inhibitors [D27.505.519.389.400]
Therapeutic Uses [D27.505.954]
Anti-Infective Agents [D27.505.954.122]
Anti-Bacterial Agents [D27.505.954.122.085]
beta-Lactamase Inhibitors [D27.505.954.122.085.516]

Below are MeSH descriptors whose meaning is related to "beta-Lactamase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "beta-Lactamase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "beta-Lactamase Inhibitors" by people in this website by year, and whether "beta-Lactamase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 30 publications over 16 distinct years, with a maximum of 6 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1996	1	0	1
2003	1	1	2
2004	1	0	1
2009	1	0	1
2011	3	0	3
2012	3	0	3
2013	2	0	2
2014	1	0	1
2015	0	1	1
2016	1	0	1
2018	0	1	1
2019	3	0	3
2020	3	3	6
2021	2	0	2
2022	1	0	1

Below are the most recent publications written about "beta-Lactamase Inhibitors" by people in Profiles.

Bradford PA, Bonomo RA, Bush K, Carattoli A, Feldgarden M, Haft DH, Ishii Y, Jacoby GA, Klimke W, Palzkill T, Poirel L, Rossolini GM, Tamma PD, Arias CA. Consensus on ß-Lactamase Nomenclature. Antimicrob Agents Chemother. 2022 04 19; 66(4):e0033322.

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Boragine DM, Huang W, Su LH, Palzkill T. Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction. Chembiochem. 2022 02 04; 23(3):e202100504.

View in: PubMed
Tam VH, Abodakpi H, Wang W, Ledesma KR, Merlau PR, Chan K, Altman R, Tran TT, Nikolaou M, Sofjan AK. Optimizing pharmacokinetics/pharmacodynamics of ß-lactam/ß-lactamase inhibitor combinations against high inocula of ESBL-producing bacteria. J Antimicrob Chemother. 2021 01 01; 76(1):179-183.

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Yahav D, Giske CG, Gramatniece A, Abodakpi H, Tam VH, Leibovici L. New ß-Lactam-ß-Lactamase Inhibitor Combinations. Clin Microbiol Rev. 2020 12 16; 34(1).

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Soeung V, Lu S, Hu L, Judge A, Sankaran B, Prasad BVV, Palzkill T. A drug-resistant ß-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.

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Huang W, Soeung V, Boragine DM, Palzkill T. Mapping Protein-Protein Interaction Interface Peptides with Jun-Fos Assisted Phage Display and Deep Sequencing. ACS Synth Biol. 2020 07 17; 9(7):1882-1896.

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Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T. Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. ACS Infect Dis. 2020 05 08; 6(5):1214-1227.

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Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Cabot G, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Smania A, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GM, Docquier JD, Frère JM, Galleni M, Hanson ND, Oliver A, Plésiat P, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA. A Standard Numbering Scheme for Class C ß-Lactamases. Antimicrob Agents Chemother. 2020 02 21; 64(3).

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Lu S, Soeung V, Nguyen HAT, Long SW, Musser JM, Palzkill T. Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC ß-Lactamases from Klebsiella pneumoniae Clinical Isolates. mSphere. 2020 01 08; 5(1).

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Abodakpi H, Wanger A, Tam VH. What the Clinical Microbiologist Should Know About Pharmacokinetics/Pharmacodynamics in the Era of Emerging Multidrug Resistance: Focusing on ß-Lactam/ß-Lactamase Inhibitor Combinations. Clin Lab Med. 2019 09; 39(3):473-485.

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