Positive Regulatory Domain I-Binding Factor 1
"Positive Regulatory Domain I-Binding Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.
| Descriptor ID |
D000074462
|
| MeSH Number(s) |
D08.811.913.555.500.800.700 D12.776.260.703.650 D12.776.930.780.904
|
| Concept/Terms |
Positive Regulatory Domain I-Binding Factor 1- Positive Regulatory Domain I-Binding Factor 1
- Positive Regulatory Domain I Binding Factor 1
- PRDI-BF1 Protein
- PRDI BF1 Protein
- B Lymphocyte-Induced Maturation Protein 1
- B Lymphocyte Induced Maturation Protein 1
- PRDM1 Protein
- BLIMP1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Positive Regulatory Domain I-Binding Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Positive Regulatory Domain I-Binding Factor 1".
This graph shows the total number of publications written about "Positive Regulatory Domain I-Binding Factor 1" by people in this website by year, and whether "Positive Regulatory Domain I-Binding Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Positive Regulatory Domain I-Binding Factor 1" by people in Profiles.
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Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity. Cell. 2024 Aug 08; 187(16):4373-4388.e15.
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Heading towards a dead end: The role of DND1 in germ line differentiation of human iPSCs. PLoS One. 2021; 16(10):e0258427.
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The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice. Nat Commun. 2020 06 03; 11(1):2782.
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Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1. Nucleic Acids Res. 2017 Dec 01; 45(21):12152-12169.
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BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Cancer Discov. 2017 10; 7(10):1184-1199.
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Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma. Leukemia. 2017 03; 31(3):625-636.
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Adrenomedullin 2 Improves Early Obesity-Induced Adipose Insulin Resistance by Inhibiting the Class II MHC in Adipocytes. Diabetes. 2016 08; 65(8):2342-55.
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Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells. Cell Stem Cell. 2015 May 07; 16(5):517-32.
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PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood. 2013 Oct 10; 122(15):2683-93.
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Lessons for inductive germline determination. Mol Reprod Dev. 2013 Aug; 80(8):590-609.