FREDERICK PEREIRA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Otolaryngology-Head and Neck Surgery
    DivisionOtolaryngology

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen CA, Wang W, Pedersen SE, Raman A, Seymour ML, Ruiz FR, Xia A, van der Heijden ME, Wang L, Yin J, Lopez J, Rech ME, Lewis RA, Wu SM, Liu Z, Pereira FA, Pautler RG, Zoghbi HY, Schaaf CP. Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity. Hum Mol Genet. 2020 03 27; 29(5):705-715. PMID: 31600777.
      Citations:    Fields:    
    2. Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M. Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy. 2018; 14(8):1419-1434. PMID: 29916295.
      Citations: 18     Fields:    Translation:AnimalsCells
    3. Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Liu Z, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CP. Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome. Am J Hum Genet. 2018 02 01; 102(2):296-308. PMID: 29395075.
      Citations: 8     Fields:    Translation:AnimalsCells
    4. Xie WR, Jen HI, Seymour ML, Yeh SY, Pereira FA, Groves AK, Klisch TJ, Zoghbi HY. An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017 09 06; 37(36):8583-8594. PMID: 28729444.
      Citations: 5     Fields:    Translation:AnimalsCells
    5. Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017 02 06; 8:14338. PMID: 28165011.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    6. Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HY. Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. Elife. 2016 06 21; 5. PMID: 27328325.
      Citations: 24     Fields:    Translation:AnimalsCells
    7. Seymour ML, Rajagopalan L, Duret G, Volk MJ, Liu H, Brownell WE, Pereira FA. Membrane prestin expression correlates with the magnitude of prestin-associated charge movement. Hear Res. 2016 09; 339:50-9. PMID: 27262187.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Seymour ML, Pereira FA. Survival of auditory hair cells. Cell Tissue Res. 2015 Jul; 361(1):59-63. PMID: 25743696.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Xia A, Song Y, Wang R, Gao SS, Clifton W, Raphael P, Chao SI, Pereira FA, Groves AK, Oghalai JS. Prestin regulation and function in residual outer hair cells after noise-induced hearing loss. PLoS One. 2013; 8(12):e82602. PMID: 24376553.
      Citations: 25     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Chiang DY, Cuthbertson DW, Ruiz FR, Li N, Pereira FA. A coregulatory network of NR2F1 and microRNA-140. PLoS One. 2013; 8(12):e83358. PMID: 24349493.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    11. Cai T, Seymour ML, Zhang H, Pereira FA, Groves AK. Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti. J Neurosci. 2013 Jun 12; 33(24):10110-22. PMID: 23761906.
      Citations: 41     Fields:    Translation:AnimalsCells
    12. Kim BJ, Zaveri HP, Shchelochkov OA, Yu Z, Hernández-García A, Seymour ML, Oghalai JS, Pereira FA, Stockton DW, Justice MJ, Lee B, Scott DA. An allelic series of mice reveals a role for RERE in the development of multiple organs affected in chromosome 1p36 deletions. PLoS One. 2013; 8(2):e57460. PMID: 23451234.
      Citations: 13     Fields:    Translation:AnimalsCells
    13. Ma X, Lin Y, Lin L, Qin G, Pereira FA, Haymond MW, Butte NF, Sun Y. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E422-31. PMID: 22669248.
      Citations: 15     Fields:    Translation:Animals
    14. Somma G, Alger HM, McGuire RM, Kretlow JD, Ruiz FR, Yatsenko SA, Stankiewicz P, Harrison W, Funk E, Bergamaschi A, Oghalai JS, Mikos AG, Overbeek PA, Pereira FA. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. J Assoc Res Otolaryngol. 2012 Jun; 13(3):335-49. PMID: 22383091.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. McGuire RM, Silberg JJ, Pereira FA, Raphael RM. Selective cell-surface labeling of the molecular motor protein prestin. Biochem Biophys Res Commun. 2011 Jun 24; 410(1):134-9. PMID: 21651892.
      Citations: 1     Fields:    Translation:HumansCells
    16. Xia A, Gao SS, Yuan T, Osborn A, Bress A, Pfister M, Maricich SM, Pereira FA, Oghalai JS. Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation. Dis Model Mech. 2010 Mar-Apr; 3(3-4):209-23. PMID: 20142329.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    17. Montemayor C, Montemayor OA, Ridgeway A, Lin F, Wheeler DA, Pletcher SD, Pereira FA. Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI. PLoS One. 2010 Jan 27; 5(1):e8910. PMID: 20111703.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    18. McGuire RM, Liu H, Pereira FA, Raphael RM. Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin. J Biol Chem. 2010 Jan 29; 285(5):3103-13. PMID: 19926791.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Rajagopalan L, Organ-Darling LE, Liu H, Davidson AL, Raphael RM, Brownell WE, Pereira FA. Glycosylation regulates prestin cellular activity. J Assoc Res Otolaryngol. 2010 Mar; 11(1):39-51. PMID: 19898896.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Minor JS, Tang HY, Pereira FA, Alford RL. DNA sequence analysis of SLC26A5, encoding prestin, in a patient-control cohort: identification of fourteen novel DNA sequence variations. PLoS One. 2009 Jun 02; 4(6):e5762. PMID: 19492055.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Rajagopalan L, Pereira FA, Lichtarge O, Brownell WE. Identification of functionally important residues/domains in membrane proteins using an evolutionary approach coupled with systematic mutational analysis. Methods Mol Biol. 2009; 493:287-97. PMID: 18839354.
      Citations: 4     Fields:    Translation:Cells
    22. Ricardo Cristobal Paul Popper Fred A. Pereira. Ballenger's Otorhinolaryngology: Head and Neck Surgery, 17th Edition By James Byron Snow & P. Ashley Wackym. Hair Cell Regeneration. 2009; 1:89-99. View Publication.
    23. Sfondouris J, Rajagopalan L, Pereira FA, Brownell WE. Membrane composition modulates prestin-associated charge movement. J Biol Chem. 2008 Aug 15; 283(33):22473-81. PMID: 18567583.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    24. Xia A, Wooltorton JR, Palmer DJ, Ng P, Pereira FA, Eatock RA, Oghalai JS. Functional prestin transduction of immature outer hair cells from normal and prestin-null mice. J Assoc Res Otolaryngol. 2008 Sep; 9(3):307-20. PMID: 18506528.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    25. Wenzel GI, Xia A, Funk E, Evans MB, Palmer DJ, Ng P, Pereira FA, Oghalai JS. Helper-dependent adenovirus-mediated gene transfer into the adult mouse cochlea. Otol Neurotol. 2007 Dec; 28(8):1100-8. PMID: 18043435.
      Citations: 16     Fields:    Translation:AnimalsCells
    26. Rajagopalan L, Greeson JN, Xia A, Liu H, Sturm A, Raphael RM, Davidson AL, Oghalai JS, Pereira FA, Brownell WE. Tuning of the outer hair cell motor by membrane cholesterol. J Biol Chem. 2007 Dec 14; 282(50):36659-70. PMID: 17933870.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    27. Xia A, Visosky AM, Cho JH, Tsai MJ, Pereira FA, Oghalai JS. Altered traveling wave propagation and reduced endocochlear potential associated with cochlear dysplasia in the BETA2/NeuroD1 null mouse. J Assoc Res Otolaryngol. 2007 Dec; 8(4):447-63. PMID: 17701252.
      Citations: 25     Fields:    Translation:Animals
    28. Zhang R, Qian F, Rajagopalan L, Pereira FA, Brownell WE, Anvari B. Prestin modulates mechanics and electromechanical force of the plasma membrane. Biophys J. 2007 Jul 01; 93(1):L07-9. PMID: 17468166.
      Citations: 12     Fields:    Translation:HumansCells
    29. Sturm AK, Rajagopalan L, Yoo D, Brownell WE, Pereira FA. Functional expression and microdomain localization of prestin in cultured cells. Otolaryngol Head Neck Surg. 2007 Mar; 136(3):434-9. PMID: 17321873.
      Citations: 21     Fields:    Translation:HumansCells
    30. Rajagopalan L, Patel N, Madabushi S, Goddard JA, Anjan V, Lin F, Shope C, Farrell B, Lichtarge O, Davidson AL, Brownell WE, Pereira FA. Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis. J Neurosci. 2006 Dec 06; 26(49):12727-34. PMID: 17151276.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    31. Tang LS, Montemayor C, Pereira FA. Sensorineural hearing loss: potential therapies and gene targets for drug development. IUBMB Life. 2006 Sep; 58(9):525-30. PMID: 17002980.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    32. Tang LS, Alger HM, Pereira FA. COUP-TFI controls Notch regulation of hair cell and support cell differentiation. Development. 2006 Sep; 133(18):3683-93. PMID: 16914494.
      Citations: 24     Fields:    Translation:AnimalsCells
    33. Greeson JN, Organ LE, Pereira FA, Raphael RM. Assessment of prestin self-association using fluorescence resonance energy transfer. Brain Res. 2006 May 26; 1091(1):140-50. PMID: 16626645.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    34. Miller JH, Nawarathna D, Warmflash D, Pereira FA, Brownell WE. Dielectric properties of yeast cells expressed with the motor protein prestin. J Biol Phys. 2005 Dec; 31(3-4):465-75. PMID: 23345911.
      Citations: 1     Fields:    
    35. Tang HY, Xia A, Oghalai JS, Pereira FA, Alford RL. High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss. BMC Med Genet. 2005 Aug 08; 6:30. PMID: 16086836.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    36. Tang LS, Alger HM, Lin F, Pereira FA. Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear. Gene Expr Patterns. 2005 Jun; 5(5):587-92. PMID: 15907456.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Anvari B, Qian F, Pereira F, Brownell W. High frequency electrically-induced force generation by cellular plasma membranes. Conf Proc IEEE Eng Med Biol Soc. 2005; 2006:1055-7. PMID: 17282369.
      Citations:    Fields:    
    38. Zhang Z, Burch PE, Cooney AJ, Lanz RB, Pereira FA, Wu J, Gibbs RA, Weinstock G, Wheeler DA. Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome. Genome Res. 2004 Apr; 14(4):580-90. PMID: 15059999.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    39. Wang P, Pereira FA, Beasley D, Zheng H. Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development. 2003 Oct; 130(20):5019-29. PMID: 12930775.
      Citations: 38     Fields:    Translation:AnimalsCells
    40. Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J. Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J Biol Chem. 2002 Nov 22; 277(47):45356-60. PMID: 12368298.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    41. Ponnio T, Burton Q, Pereira FA, Wu DK, Conneely OM. The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol Cell Biol. 2002 Feb; 22(3):935-45. PMID: 11784868.
      Citations: 27     Fields:    Translation:Animals
    42. Pereira FA. Whole-mount histochemical detection of beta-galactosidase activity. Curr Protoc Mol Biol. 2001 May; Chapter 14:Unit 14.14. PMID: 18265109.
      Citations: 4     Fields:    Translation:HumansAnimals
    43. Chung AC, Katz D, Pereira FA, Jackson KJ, DeMayo FJ, Cooney AJ, O'Malley BW. Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation. Mol Cell Biol. 2001 Jan; 21(2):663-77. PMID: 11134352.
      Citations: 35     Fields:    Translation:Animals
    44. Liu M, Pereira FA, Price SD, Chu MJ, Shope C, Himes D, Eatock RA, Brownell WE, Lysakowski A, Tsai MJ. Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. Genes Dev. 2000 Nov 15; 14(22):2839-54. PMID: 11090132.
      Citations: 84     Fields:    Translation:AnimalsCells
    45. Pereira FA, Tsai MJ, Tsai SY. COUP-TF orphan nuclear receptors in development and differentiation. Cell Mol Life Sci. 2000 Sep; 57(10):1388-98. PMID: 11078018.
      Citations: 63     Fields:    Translation:HumansAnimals
    46. Zhou C, Qiu Y, Pereira FA, Crair MC, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. Neuron. 1999 Dec; 24(4):847-59. PMID: 10624948.
      Citations: 51     Fields:    Translation:AnimalsCells
    47. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 1999 Apr 15; 13(8):1037-49. PMID: 10215630.
      Citations: 145     Fields:    Translation:Animals
    48. Krishnan V, Pereira FA, Qiu Y, Chen CH, Beachy PA, Tsai SY, Tsai MJ. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science. 1997 Dec 12; 278(5345):1947-50. PMID: 9395397.
      Citations: 42     Fields:    Translation:AnimalsCells
    49. Qiu Y, Pereira FA, DeMayo FJ, Lydon JP, Tsai SY, Tsai MJ. Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997 Aug 01; 11(15):1925-37. PMID: 9271116.
      Citations: 71     Fields:    Translation:AnimalsCells
    50. Qiu Y, Krishnan V, Pereira FA, Tsai SY, Tsai MJ. Chicken ovalbumin upstream promoter-transcription factors and their regulation. J Steroid Biochem Mol Biol. 1996 Jan; 56(1-6 Spec No):81-5. PMID: 8603050.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    51. Pereira FA, Qiu Y, Tsai MJ, Tsai SY. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis. J Steroid Biochem Mol Biol. 1995 Jun; 53(1-6):503-8. PMID: 7626501.
      Citations: 28     Fields:    Translation:Animals
    52. Belsham DD, Pereira F, Greenberg CR, Liao S, Wrogemann K. Leu-676-Pro mutation of the androgen receptor causes complete androgen insensitivity syndrome in a large Hutterite kindred. Hum Mutat. 1995; 5(1):28-33. PMID: 7537149.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    53. Pereira FA, Rosenmann E, Nylen EG, Wrogemann K. Human cytosolic aldehyde dehydrogenase in androgen insensitivity syndrome. Adv Exp Med Biol. 1993; 328:45-50. PMID: 8493922.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    54. Prior L, Bordet S, Trifiro MA, Mhatre A, Kaufman M, Pinsky L, Wrogeman K, Belsham DD, Pereira F, Greenberg C, et al. Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes. Am J Hum Genet. 1992 Jul; 51(1):143-55. PMID: 1609793.
      Citations: 5     Fields:    Translation:HumansCells
    55. Pereira F, Rosenmann E, Nylen E, Kaufman M, Pinsky L, Wrogemann K. The 56 kDa androgen binding protein is an aldehyde dehydrogenase. Biochem Biophys Res Commun. 1991 Mar 29; 175(3):831-8. PMID: 1709013.
      Citations: 9     Fields:    Translation:HumansCells
    56. Pereira F, Belsham D, Duerksen K, Rosenmann E, Kaufman M, Pinsky L, Wrogemann K. The 56 kDa androgen-binding protein in human genital skin fibroblasts: its relation to the human androgen receptor. Mol Cell Endocrinol. 1990 Jan 22; 68(2-3):195-204. PMID: 2311825.
      Citations: 1     Fields:    Translation:HumansCells
    57. Belsham DD, Rosenmann E, Pereira FA, Williams SG, Turney MK, Kovacs WJ, Faber LE, Wrogemann K. The 56 kDa protein of human genital skin fibroblasts is identical to that radiolabelled by [3H]dihydrotestosterone 17 beta-bromoacetate. J Steroid Biochem. 1989 Sep; 33(3):389-94. PMID: 2779230.
      Citations:    Fields:    Translation:HumansCells
    58. Wrogemann K, Pereira F, Belsham D, Kaufman M, Pinsky L, Rosenmann E. An abundant 56 kD protein with low affinity androgen binding: another member of the steroid/thyroid receptor family? Biochem Biophys Res Commun. 1988 Sep 15; 155(2):907-13. PMID: 3262343.
      Citations:    Fields:    Translation:HumansCells
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