InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
Houston, TX 77030
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    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

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    K99DK085330     (XU, YONG)Sep 1, 2009 - Aug 31, 2010
    Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Role: Principal Investigator

    R00DK085330     (XU, YONG)Sep 20, 2010 - Aug 31, 2013
    Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Role: Principal Investigator

    R01DK093587     (XU, YONG)Sep 27, 2011 - Aug 31, 2016
    CNS Circuits Mediating Estrogenic Regulation on Energy and Glucose Homeostasis
    Role: Principal Investigator

    R01DK101379     (XU, YONG)Sep 15, 2014 - Jul 31, 2018
    Targeting hypothalamic steroid receptor co-activator-1 to treat obesity
    Role: Principal Investigator

    R01DK117281     (XU, YONG)Apr 1, 2018 - Mar 31, 2023
    Neurobiology for the sex differences in energy balance
    Role: Principal Investigator

    R01DK115761     (FRAZER, ALAN)Sep 1, 2018 - May 31, 2022
    Hypothalamic Grb10 and body weight
    Role: Co-Principal Investigator

    R01DK120858     (XU, YONG)Sep 15, 2020 - Jun 30, 2024
    Role: Principal Investigator

    R01DK125480     (XU, YONG)Sep 15, 2020 - Jun 30, 2024
    Brain Estrogen Regulates Energy and Glucose Balance
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xia G, Han Y, Meng F, He Y, Srisai D, Farias M, Dang M, Palmiter RD, Xu Y, Wu Q. Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit. Mol Psychiatry. 2021 Mar 26. PMID: 33767348.
      Citations:    Fields:    
    2. Parchem JG, Kanasaki K, Lee SB, Kanasaki M, Yang JL, Xu Y, Earl KM, Keuls RA, Gattone VH, Kalluri R. STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects. JCI Insight. 2021 Jan 25; 6(2). PMID: 33301424.
      Citations:    Fields:    
    3. Yang Y, Xu Y. The central melanocortin system and human obesity. J Mol Cell Biol. 2021 01 19; 12(10):785-797. PMID: 32976556.
      Citations:    Fields:    
    4. Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun Z, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Transl Psychiatry. 2021 01 05; 11(1):11. PMID: 33414382.
      Citations:    Fields:    
    5. Liu H, He Y, Beck J, da Silva Teixeira S, Harrison K, Xu Y, Sisley S. Defining vitamin D receptor expression in the brain using a novel VDRCre mouse. J Comp Neurol. 2020 Dec 25. PMID: 33368246.
      Citations:    Fields:    
    6. Fu Y, Kaneko K, Lin HY, Mo Q, Xu Y, Suganami T, Ravn P, Fukuda M. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. 2020 09 01; 161(9). PMID: 32603429.
      Citations:    Fields:    Translation:AnimalsCells
    7. Sun Z, Xu Y. Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain. Endocrinology. 2020 08 01; 161(8). PMID: 32449767.
      Citations: 2     Fields:    Translation:HumansAnimals
    8. Yu K, He Y, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Gourdy P, Arnal JF, Lenfant F, Xu Y, Wang C. 17ß-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERa signaling. Mol Metab. 2020 12; 42:101053. PMID: 32712433.
      Citations: 2     Fields:    
    9. da Silva Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley S. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. J Steroid Biochem Mol Biol. 2020 06; 200:105690. PMID: 32408067.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-a expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun. 2020 05 01; 11(1):2165. PMID: 32358493.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2076-2083. PMID: 31924743.
      Citations: 4     Fields:    Translation:HumansAnimals
    12. Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y. A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia. Mol Psychiatry. 2020 05; 25(5):1006-1021. PMID: 31485012.
      Citations: 8     Fields:    Translation:Animals
    13. Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. J Clin Invest. 2019 08 12; 129(9):3786-3791. PMID: 31403469.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Xu Y, Lu Y, Cassidy RM, Mangieri LR, Zhu C, Huang X, Jiang Z, Justice NJ, Xu Y, Arenkiel BR, Tong Q. Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses. Nat Commun. 2019 08 01; 10(1):3446. PMID: 31371721.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Mangieri LR, Jiang Z, Lu Y, Xu Y, Cassidy RM, Justice N, Xu Y, Arenkiel BR, Tong Q. Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit. eNeuro. 2019 Jul/Aug; 6(4). PMID: 31331938.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Cordonier EL, Liu T, Saito K, Chen SS, Xu Y, Fukuda M. Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression. J Endocr Soc. 2019 Jul 01; 3(7):1246-1260. PMID: 31214662.
    17. Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, O'Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 04 12; 10(1):1718. PMID: 30979869.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    18. Wang C, Xu Y. Mechanisms for Sex Differences in Energy Homeostasis. J Mol Endocrinol. 2019 02; 62(2):R129-R143. PMID: 31130779.
      Citations: 7     Fields:    Translation:HumansCells
    19. Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019 02; 22(2):205-217. PMID: 30664766.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, Han G, Newell-Fugate A, Tian Y, Majeti R, Liu W, Xu Y, Wu C, Allred K, Allred C, Sun Y, Guo S. Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1. Diabetes. 2019 02; 68(2):291-304. PMID: 30487265.
      Citations: 23     Fields:    Translation:AnimalsCells
    21. Xu Y, López M. Central regulation of energy metabolism by estrogens. Mol Metab. 2018 09; 15:104-115. PMID: 29886181.
      Citations: 16     Fields:    Translation:HumansAnimals
    22. Yu S, Cheng H, François M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud HR, Münzberg H. Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife. 2018 05 15; 7. PMID: 29761783.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 04 18; 9(1):1544. PMID: 29670083.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Zhang P, Kuang H, He Y, Idiga SO, Li S, Chen Z, Yang Z, Cai X, Zhang K, Potthoff MJ, Xu Y, Lin JD. NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight. 2018 03 08; 3(5). PMID: 29515030.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Mangieri LR, Lu Y, Xu Y, Cassidy RM, Xu Y, Arenkiel BR, Tong Q. A neural basis for antagonistic control of feeding and compulsive behaviors. Nat Commun. 2018 01 04; 9(1):52. PMID: 29302029.
      Citations: 10     Fields:    Translation:Animals
    26. Xu J, Zhu C, Zhang M, Tong Q, Wan X, Liao Z, Cai X, Xu Y, Yuan Y, Wang L, Zhu X, Wang S, Gao P, Xi Q, Xu Y, Jiang Q, Shu G. Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway. Metabolism. 2018 02; 79:10-23. PMID: 29080813.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    27. Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR. Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017 Dec; 23(12):1444-1453. PMID: 29106398.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    28. Zhu C, Xu P, He Y, Yuan Y, Wang T, Cai X, Yu L, Yang L, Wu J, Wang L, Zhu X, Wang S, Gao P, Xi Q, Zhang Y, Xu Y, Jiang Q, Shu G. Heparin Increases Food Intake through AgRP Neurons. Cell Rep. 2017 Sep 05; 20(10):2455-2467. PMID: 28877477.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. 2017 May-Jun; 4(3). PMID: 28560316.
      Citations: 2     Fields:    Translation:AnimalsCells
    30. Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis. Int J Mol Sci. 2017 Apr 14; 18(4). PMID: 28420089.
      Citations: 9     Fields:    Translation:AnimalsCells
    31. Xu Y, O'Malley BW, Elmquist JK. Brain nuclear receptors and body weight regulation. J Clin Invest. 2017 Apr 03; 127(4):1172-1180. PMID: 28218618.
      Citations: 5     Fields:    Translation:HumansAnimals
    32. Xu Y. Brain Estrogens and Feeding Behavior. Adv Exp Med Biol. 2017; 1043:337-357. PMID: 29224102.
      Citations:    Fields:    Translation:HumansAnimalsCells
    33. Hinton AO, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644. PMID: 28006821.
      Citations: 2     Fields:    Translation:Animals
    34. Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Yan X, Hyseni I, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism. 2017 05; 70:152-159. PMID: 28403939.
      Citations: 2     Fields:    Translation:Animals
    35. He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016 11 08; 17(7):1807-1818. PMID: 27829152.
      Citations: 6     Fields:    Translation:AnimalsCells
    36. Kaneko K, Xu P, Cordonier EL, Chen SS, Ng A, Xu Y, Morozov A, Fukuda M. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell Rep. 2016 09 13; 16(11):3003-3015. PMID: 27626668.
      Citations: 12     Fields:    Translation:AnimalsCells
    37. Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton A, Zhu L, Shu G, Myers MG, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry. 2017 05 01; 81(9):737-747. PMID: 27516377.
      Citations: 21     Fields:    Translation:AnimalsCells
    38. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488.
      Citations: 11     Fields:    Translation:AnimalsCells
    39. Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba OY, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes. 2016 08; 65(8):2169-78. PMID: 27207529.
      Citations: 21     Fields:    Translation:AnimalsCells
    40. Hu F, Xu Y, Liu F. Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E994-E1002. PMID: 27166282.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    41. Hinton AO, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen Receptor-a in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females. Hypertension. 2016 06; 67(6):1321-30. PMID: 27091896.
      Citations: 3     Fields:    Translation:Animals
    42. Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Sci Rep. 2016 Mar 18; 6:23459. PMID: 26988598.
      Citations: 20     Fields:    Translation:Animals
    43. Meng F, Han Y, Srisai D, Belakhov V, Farias M, Xu Y, Palmiter RD, Baasov T, Wu Q. New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3645-50. PMID: 26976589.
      Citations: 18     Fields:    Translation:AnimalsCells
    44. Xu Y, Chang JT, Myers MG, Xu Y, Tong Q. Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release. Diabetes. 2016 04; 65(4):1040-9. PMID: 26822087.
      Citations: 10     Fields:    Translation:AnimalsCells
    45. Fan S, Dakshinamoorthy J, Kim ER, Xu Y, Huang C, Tong Q. An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide Y. Sci Rep. 2016 Jan 27; 6:19980. PMID: 26813148.
      Citations: 2     Fields:    Translation:AnimalsCells
    46. Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton AO, Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-a-expressing neurons using a new ERa-ZsGreen reporter mouse line. Metabolism. 2016 Apr; 65(4):522-32. PMID: 26975544.
      Citations: 9     Fields:    Translation:AnimalsCells
    47. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425.
      Citations: 17     Fields:    Translation:AnimalsCells
    48. Xu P, Cao X, Xu Y. Targeting brain estrogen receptor for binge eating. Oncotarget. 2015 Sep 15; 6(27):23044-5. PMID: 26309082.
      Citations:    Fields:    Translation:HumansAnimalsCells
    49. Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton AO, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates Pro-Opiomelanocortin Neurons in the Arcuate Nucleus. Neuroendocrinology. 2016; 103(5):476-488. PMID: 26337236.
      Citations: 9     Fields:    Translation:AnimalsCells
    50. Kim ER, Wu Z, Sun H, Xu Y, Mangieri LR, Xu Y, Tong Q. Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia. J Neurosci. 2015 Jul 22; 35(29):10440-50. PMID: 26203139.
      Citations: 16     Fields:    Translation:AnimalsCells
    51. Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol. 2015 Jul; 172(14):3510-21. PMID: 25817043.
      Citations: 4     Fields:    Translation:AnimalsCells
    52. Saito K, Cao X, He Y, Xu Y. Progress in the molecular understanding of central regulation of body weight by estrogens. Obesity (Silver Spring). 2015 May; 23(5):919-26. PMID: 25865677.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    53. Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042.
      Citations: 15     Fields:    Translation:Animals
    54. Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci. 2015 Feb 25; 35(8):3312-8. PMID: 25716832.
      Citations: 32     Fields:    Translation:AnimalsCells
    55. Scott MM, Xu Y, Elias CF, Williams KW. Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis. Front Neurosci. 2014; 8:384. PMID: 25520610.
      Citations: 3     
    56. Shu G, Lu NS, Zhu XT, Xu Y, Du MQ, Xie QP, Zhu CJ, Xu Q, Wang SB, Wang LN, Gao P, Xi QY, Zhang YL, Jiang QY. Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo. J Nutr Biochem. 2014 Dec; 25(12):1296-308. PMID: 25283330.
      Citations: 11     Fields:    Translation:AnimalsCells
    57. Xu Y, Kim ER, Fan S, Xia Y, Xu Y, Huang C, Tong Q. Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochem Biophys Res Commun. 2014 Aug 22; 451(2):184-9. PMID: 25065745.
      Citations: 5     Fields:    Translation:Animals
    58. Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest. 2013 Dec; 123(12):5061-70. PMID: 24177424.
      Citations: 75     Fields:    Translation:AnimalsCells
    59. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 02; 18(1):86-98. PMID: 23823479.
      Citations: 31     Fields:    Translation:AnimalsCells
    60. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and ß-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ß-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38. PMID: 23547261.
      Citations: 77     Fields:    Translation:AnimalsCells
    61. Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O'Malley BW, Xu Y. Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology. 2013 Jan; 154(1):150-8. PMID: 23211707.
      Citations: 25     Fields:    Translation:AnimalsCells
    62. Xu Y, Faulkner LD, Hill JW. Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons. Front Endocrinol (Lausanne). 2011; 2:98. PMID: 22649394.
      Citations: 8     
    63. Xu Y, Elmquist JK, Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci. 2011 Dec; 1243:1-14. PMID: 22211889.
      Citations: 50     Fields:    Translation:HumansAnimals
    64. Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab. 2011 Oct 05; 14(4):453-65. PMID: 21982706.
      Citations: 213     Fields:    Translation:AnimalsCells
    65. Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 2011 Aug 11; 71(3):488-97. PMID: 21835345.
      Citations: 79     Fields:    Translation:AnimalsCells
    66. Kim KW, Zhao L, Donato J, Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10673-8. PMID: 21636788.
      Citations: 63     Fields:    Translation:Animals
    67. Kim KW, Sohn JW, Kohno D, Xu Y, Williams K, Elmquist JK. SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis. Mol Cell Endocrinol. 2011 Apr 10; 336(1-2):219-23. PMID: 21111025.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    68. Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci. 2010 Nov 03; 30(44):14630-4. PMID: 21048120.
      Citations: 33     Fields:    Translation:Animals
    69. Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec; 13(12):1457-9. PMID: 21037584.
      Citations: 45     Fields:    Translation:AnimalsCells
    70. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 07; 12(1):88-95. PMID: 20620998.
      Citations: 54     Fields:    Translation:AnimalsCells
    71. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010 Apr 07; 11(4):286-97. PMID: 20374961.
      Citations: 167     Fields:    Translation:AnimalsCells
    72. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82. PMID: 19819947.
      Citations: 48     Fields:    Translation:AnimalsCells
    73. Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26; 60(4):582-9. PMID: 19038216.
      Citations: 110     Fields:    Translation:Animals
    74. Xu Y, Krukoff TL. Adrenomedullin stimulates nitric oxide production from primary rat hypothalamic neurons: roles of calcium and phosphatases. Mol Pharmacol. 2007 Jul; 72(1):112-20. PMID: 17446268.
      Citations: 11     Fields:    Translation:AnimalsCells
    75. Ma X, Wang H, Deng Y, Liu Z, Xu Y, Pan X, Musser JM, Graviss EA. rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China. J Clin Microbiol. 2006 Sep; 44(9):3409-12. PMID: 16954287.
      Citations: 29     Fields:    Translation:HumansCellsPHPublic Health
    76. Xu Y, Krukoff TL. Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A. Br J Pharmacol. 2006 May; 148(1):70-7. PMID: 16501581.
      Citations: 3     Fields:    Translation:Animals
    77. Xu Y, Krukoff TL. Adrenomedullin stimulates nitric oxide release from SK-N-SH human neuroblastoma cells by modulating intracellular calcium mobilization. Endocrinology. 2005 May; 146(5):2295-305. PMID: 15677761.
      Citations: 4     Fields:    Translation:HumansCells
    78. Xu Y, Krukoff TL. Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA. Regul Pept. 2004 Jun 15; 119(1-2):21-30. PMID: 15093693.
      Citations: 6     Fields:    Translation:AnimalsCells
    79. Xu Y, Krukoff TL. Adrenomedullin in the rostral ventrolateral medulla increases arterial pressure and heart rate: roles of glutamate and nitric oxide. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R729-34. PMID: 15178541.
      Citations: 9     Translation:AnimalsCells
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