YONG XU

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
    Collapse research activities and funding
    R01AG080392     (XU, YONG)Sep 15, 2023 - Jun 30, 2028
    NIH
    5-HT 2C Receptor and Alzheimer's Disease
    Role: Principal Investigator

    R01DK136479     (XU, YONG)Aug 25, 2023 - Apr 30, 2027
    NIH
    Neurobiology for Lac-Phe Hypophagia
    Role: Principal Investigator

    R01DK120858     (TONG, QINGCHUN ;XU, YONG)Sep 15, 2020 - Jun 30, 2024
    NIH
    5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKE
    Role: Principal Investigator

    R01DK125480     (XU, YONG)Sep 15, 2020 - Jun 30, 2024
    NIH
    Brain Estrogen Regulates Energy and Glucose Balance
    Role: Principal Investigator

    R01DK115761     (FRAZER, ALAN)Sep 1, 2018 - May 31, 2022
    NIH
    Hypothalamic Grb10 and body weight
    Role: Co-Principal Investigator

    R01DK117281     (XU, YONG)Apr 1, 2018 - Mar 31, 2023
    NIH
    Neurobiology for the sex differences in energy balance
    Role: Principal Investigator

    R01DK101379     (XU, YONG)Sep 15, 2014 - Jul 31, 2018
    NIH
    Targeting hypothalamic steroid receptor co-activator-1 to treat obesity
    Role: Principal Investigator

    R01DK093587     (XU, YONG)Sep 27, 2011 - Aug 31, 2016
    NIH
    CNS Circuits Mediating Estrogenic Regulation on Energy and Glucose Homeostasis
    Role: Principal Investigator

    R00DK085330     (XU, YONG)Sep 20, 2010 - Aug 31, 2013
    NIH
    Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Role: Principal Investigator

    K99DK085330     (XU, YONG)Sep 1, 2009 - Aug 31, 2010
    NIH
    Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cai J, Jiang Y, Xu Y, Jiang Z, Young C, Li H, Ortiz-Guzman J, Zhuo Y, Li Y, Xu Y, Arenkiel BR, Tong Q. An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes. Neuron. 2024 Feb 07; 112(3):458-472.e6. PMID: 38056455.
      Citations:    Fields:    
    2. Tu L, He Y, Xu Y. Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus. Neural Regen Res. 2024 Jun 01; 19(6):1177-1178. PMID: 37905852.
      Citations:    
    3. Conde K, Fang S, Xu Y. Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review. Cell Biosci. 2023 Aug 07; 13(1):143. PMID: 37550777; PMCID: PMC10408233.
      Citations:    
    4. Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarcelli NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. J Clin Invest. 2023 07 17; 133(14). PMID: 37261917; PMCID: PMC10348766.
      Citations:    Fields:    Translation:AnimalsCells
    5. Xu Y, Jiang Z, Li H, Cai J, Jiang Y, Otiz-Guzman J, Xu Y, Arenkiel BR, Tong Q. Lateral septum as a melanocortin downstream site in obesity development. Cell Rep. 2023 05 30; 42(5):112502. PMID: 37171957; PMCID: PMC10317244.
      Citations:    Fields:    Translation:Humans
    6. Li H, Xu Y, Jiang Y, Jiang Z, Otiz-Guzman J, Morrill JC, Cai J, Mao Z, Xu Y, Arenkiel BR, Huang C, Tong Q. The melanocortin action is biased toward protection from weight loss in mice. Nat Commun. 2023 04 17; 14(1):2200. PMID: 37069175; PMCID: PMC10110624.
      Citations: 2     Fields:    Translation:Animals
    7. Han Y, He Y, Harris L, Xu Y, Wu Q. Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity. Elife. 2023 04 12; 12. PMID: 37043384; PMCID: PMC10097419.
      Citations: 1     Fields:    Translation:HumansCells
    8. Wang M, Yang Y, Xu Y. Brain nuclear receptors and cardiovascular function. Cell Biosci. 2023 Jan 20; 13(1):14. PMID: 36670468.
      Citations: 1     
    9. Liu H, He Y, Bai J, Zhang C, Zhang F, Yang Y, Luo H, Yu M, Liu H, Tu L, Zhang N, Yin N, Han J, Yan Z, Scarcelli NA, Conde KM, Wang M, Bean JC, Potts CHS, Wang C, Hu F, Liu F, Xu Y. Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. Nat Metab. 2023 01; 5(1):147-164. PMID: 36593271.
      Citations: 2     Fields:    Translation:Animals
    10. He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Sadaf Farooqi I. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nat Med. 2022 12; 28(12):2537-2546. PMID: 36536256; PMCID: PMC9800280.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Yu M, Bean JC, Liu H, He Y, Yang Y, Cai X, Yu K, Pei Z, Liu H, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Scarcelli NA, Xu P, He Y, Xu Y, Wang C. SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis. Cell Biosci. 2022 Oct 09; 12(1):170. PMID: 36210455; PMCID: PMC9549684.
      Citations: 2     
    12. Pei Z, He Y, Bean JC, Yang Y, Liu H, Yu M, Yu K, Hyseni I, Cai X, Liu H, Qu N, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Potts CH, Scarcelli NA, Yan Z, Xu P, Wu Q, He Y, Xu Y, Wang C. Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance. Front Endocrinol (Lausanne). 2022; 13:889122. PMID: 36120438; PMCID: PMC9471380.
      Citations:    
    13. Liu H, Cai X, He Y, Xu Y. Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia. J Mol Cell Biol. 2022 08 26; 14(5). PMID: 35612989; PMCID: PMC9412745.
      Citations:    Fields:    
    14. Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Liang C, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. Publisher Correction: A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nat Neurosci. 2022 Jul; 25(7):976. PMID: 35729403.
      Citations:    Fields:    
    15. Li VL, He Y, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, van de Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ, Contrepois K. An exercise-inducible metabolite that suppresses feeding and obesity. Nature. 2022 06; 606(7915):785-790. PMID: 35705806; PMCID: PMC9767481.
      Citations:    Fields:    Translation:Animals
    16. Tu L, Fukuda M, Tong Q, Xu Y. The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis. Cell Biosci. 2022 May 26; 12(1):71. PMID: 35619170; PMCID: PMC9134642.
      Citations:    
    17. Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Liang C, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nat Neurosci. 2022 05; 25(5):646-658. PMID: 35501380; PMCID: PMC9926508.
      Citations:    Fields:    Translation:AnimalsCells
    18. Mishra I, Xie WR, Bournat JC, He Y, Wang C, Silva ES, Liu H, Ku Z, Chen Y, Erokwu BO, Jia P, Zhao Z, An Z, Flask CA, He Y, Xu Y, Chopra AR. Protein tyrosine phosphatase receptor d serves as the orexigenic asprosin receptor. Cell Metab. 2022 04 05; 34(4):549-563.e8. PMID: 35298903; PMCID: PMC8986618.
      Citations: 3     Fields:    Translation:Animals
    19. Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y, Xu P, Xu Y. An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Sci Adv. 2022 Jan 21; 8(3):eabk0185. PMID: 35044814; PMCID: PMC8769556.
      Citations: 2     Fields:    
    20. Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Rep. 2021 12 07; 37(10):110075. PMID: 34879284; PMCID: PMC8715676.
      Citations:    Fields:    Translation:HumansAnimalsCells
    21. Yan Z, He Y, Cai X, Shu G, Xu Y. Eating for hunger or pleasure: a Serotonin Model. J Mol Cell Biol. 2021 12 06; 13(9):693-694. PMID: 34480567; PMCID: PMC8648382.
      Citations:    Fields:    Translation:HumansCells
    22. Yoo ES, Li L, Jia L, Lord CC, Lee CE, Birnbaum SG, Vianna CR, Berglund ED, Cunningham KA, Xu Y, Sohn JW, Liu C. Gai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Rep. 2021 11 16; 37(7):109997. PMID: 34788630; PMCID: PMC8636014.
      Citations:    Fields:    Translation:AnimalsCells
    23. Tu L, Zhang N, Conde KM, Bean JC, Wang C, Xu Y. Free-floating Immunostaining of Mouse Brains. J Vis Exp. 2021 10 07; (176). PMID: 34694284; PMCID: PMC8981791.
      Citations:    Fields:    Translation:AnimalsCells
    24. Zhu Y, Li N, Huang M, Bartels M, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang Y, Gliniak CM, Gordillo R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE, Dogn? S. Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. Nat Commun. 2021 08 10; 12(1):4829. PMID: 34376643; PMCID: PMC8355239.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    25. Zhang N, Yan Z, Liu H, Yu M, He Y, Liu H, Liang C, Tu L, Wang L, Yin N, Han J, Scarcelli N, Yang Y, Wang C, Zeng T, Chen LL, Xu Y. Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions. Front Physiol. 2021; 12:714104. PMID: 34393830; PMCID: PMC8355523.
      Citations: 2     
    26. He Y, Cai X, Liu H, Conde KM, Xu P, Li Y, Wang C, Yu M, He Y, Liu H, Liang C, Yang T, Yang Y, Yu K, Wang J, Zheng R, Liu F, Sun Z, Heisler L, Wu Q, Tong Q, Zhu C, Shu G, Xu Y. 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding. Mol Psychiatry. 2021 12; 26(12):7211-7224. PMID: 34290371; PMCID: PMC8776930.
      Citations: 3     Fields:    Translation:Cells
    27. Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z. Author Correction: REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. Nature. 2021 Jul; 595(7865):E2. PMID: 34131305.
      Citations: 1     Fields:    
    28. Han Y, Xia G, Srisai D, Meng F, He Y, Ran Y, He Y, Farias M, Hoang G, Dietrich MO, Chen MH, Xu Y, Wu Q, T?th I. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nat Commun. 2021 06 10; 12(1):3525. PMID: 34112797; PMCID: PMC8192783.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Kaneko K, Lin HY, Fu Y, Saha PK, De la Puente-Gomez AB, Xu Y, Ohinata K, Chen P, Morozov A, Fukuda M. Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021 06 08; 6(11). PMID: 33974562; PMCID: PMC8262364.
      Citations: 3     Fields:    Translation:AnimalsCells
    30. Han Y, Xia G, He Y, He Y, Farias M, Xu Y, Wu Q. A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation. Sci Adv. 2021 05; 7(22). PMID: 34039606.
      Citations: 1     Fields:    Translation:HumansAnimals
    31. Ding Y, Liu Y, Lee DK, Tong Z, Yu X, Li Y, Xu Y, Lanz RB, O'Malley BW, Xu J. Cell lineage tracing links ERa loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). PMID: 34006643; PMCID: PMC8166171.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    32. He Y, Liu H, Yin N, Yang Y, Wang C, Yu M, Liu H, Liang C, Wang J, Tu L, Zhang N, Wang L, He Y, Fukuda M, Wu Q, Sun Z, Tong Q, Xu Y. Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss. J Neurosci. 2021 06 30; 41(26):5734-5746. PMID: 34031163; PMCID: PMC8244968.
      Citations: 1     Fields:    Translation:AnimalsCells
    33. Fan S, Xu Y, Lu Y, Jiang Z, Li H, Morrill JC, Cai J, Wu Q, Xu Y, Xue M, Arenkiel BR, Huang C, Tong Q. A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia. Nat Commun. 2021 05 11; 12(1):2662. PMID: 33976218; PMCID: PMC8113586.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Mishra I, Duerrschmid C, Ku Z, He Y, Xie W, Silva ES, Hoffman J, Xin W, Zhang N, Xu Y, An Z, Chopra AR. Asprosin-neutralizing antibodies as a treatment for metabolic syndrome. Elife. 2021 04 27; 10. PMID: 33904407; PMCID: PMC8102062.
      Citations: 6     Fields:    Translation:HumansAnimals
    35. Liu T, Xu Y, Yi CX, Tong Q, Cai D. The hypothalamus for whole-body physiology: from metabolism to aging. Protein Cell. 2022 06; 13(6):394-421. PMID: 33826123; PMCID: PMC9095790.
      Citations: 7     Fields:    Translation:Humans
    36. Xia G, Han Y, Meng F, He Y, Srisai D, Farias M, Dang M, Palmiter RD, Xu Y, Wu Q. Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit. Mol Psychiatry. 2021 07; 26(7):2837-2853. PMID: 33767348; PMCID: PMC8505263.
      Citations: 5     Fields:    Translation:Humans
    37. Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z. REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. Nature. 2021 04; 592(7856):763-767. PMID: 33762728; PMCID: PMC8085086.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    38. Wang Y, Yang Y, Wang M, Wang S, Jeong JM, Xu L, Wen Y, Emontzpohl C, Atkins CL, Duong K, Moreno NF, Yuan X, Hall DR, Dar W, Feng D, Gao B, Xu Y, Czigany Z, Colgan SP, Bynon JS, Akira S, Brown JM, Eltzschig HK, Jacobsen EA, Ju C. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Sci Transl Med. 2021 02 03; 13(579). PMID: 33536281; PMCID: PMC8167890.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    39. Liu H, He Y, Beck J, da Silva Teixeira S, Harrison K, Xu Y, Sisley S. Defining vitamin D receptor expression in the brain using a novel VDRCre mouse. J Comp Neurol. 2021 06; 529(9):2362-2375. PMID: 33368246; PMCID: PMC8053677.
      Citations: 5     Fields:    Translation:Animals
    40. Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun Z, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Transl Psychiatry. 2021 01 05; 11(1):11. PMID: 33414382; PMCID: PMC7791100.
      Citations: 5     Fields:    Translation:AnimalsCells
    41. Liu H, Wang C, Yu M, Yang Y, He Y, Liu H, Liang C, Tu L, Zhang N, Wang L, Wang J, Liu F, Hu F, Xu Y. TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner. Endocrinology. 2021 01 01; 162(1). PMID: 33034617; PMCID: PMC7685027.
      Citations: 2     Fields:    Translation:AnimalsCells
    42. Zhang Z, Reis FMCV, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Maesta-Pereira S, Shum M, Nichols I, Massa MG, Anderson S, Paul K, Liesa M, Ajijola OA, Xu Y, Adhikari A, Correa SM. Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice. Nat Commun. 2020 12 11; 11(1):6378. PMID: 33311503; PMCID: PMC7732979.
      Citations: 13     Fields:    Translation:AnimalsCells
    43. Yang Y, Xu Y. The central melanocortin system and human obesity. J Mol Cell Biol. 2020 10 01; 12(10):785-797. PMID: 32976556; PMCID: PMC7816681.
      Citations: 5     Fields:    Translation:HumansAnimals
    44. Liu H, Xu Y, Hu F. AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis. Front Endocrinol (Lausanne). 2020; 11:578830. PMID: 33071984; PMCID: PMC7538541.
      Citations: 6     Fields:    Translation:HumansAnimals
    45. Fu Y, Kaneko K, Lin HY, Mo Q, Xu Y, Suganami T, Ravn P, Fukuda M. Gut Hormone GIP Induces Inflammation and Insulin Resistance in the Hypothalamus. Endocrinology. 2020 09 01; 161(9). PMID: 32603429; PMCID: PMC7410368.
      Citations: 9     Fields:    Translation:AnimalsCells
    46. Sun Z, Xu Y. Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain. Endocrinology. 2020 08 01; 161(8). PMID: 32449767; PMCID: PMC7351129.
      Citations: 9     Fields:    Translation:HumansAnimals
    47. Kim ER, Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Van Drunen R, Ribas-Latre A, Cai ZL, Xue M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q. Paraventricular hypothalamus mediates diurnal rhythm of metabolism. Nat Commun. 2020 07 30; 11(1):3794. PMID: 32732906; PMCID: PMC7393104.
      Citations: 12     Fields:    Translation:AnimalsCells
    48. Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel BR, Wu Q, Shu G, Tong Q. Profound and redundant functions of arcuate neurons in obesity development. Nat Metab. 2020 08; 2(8):763-774. PMID: 32719538; PMCID: PMC7687864.
      Citations: 21     Fields:    Translation:AnimalsCells
    49. Yu K, He Y, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Xu Y, Wang C, Gourdy P, Arnal JF, Lenfant F. 17?-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERa signaling. Mol Metab. 2020 12; 42:101053. PMID: 32712433; PMCID: PMC7484552.
      Citations: 8     Fields:    Translation:AnimalsCells
    50. Zhu C, Xu Y, Jiang Z, Tian JB, Cassidy RM, Cai ZL, Shu G, Xu Y, Xue M, Arenkiel BR, Jiang Q, Tong Q. Disrupted hypothalamic CRH neuron responsiveness contributes to diet-induced obesity. EMBO Rep. 2020 07 03; 21(7):e49210. PMID: 32462726; PMCID: PMC7332802.
      Citations: 9     Fields:    Translation:AnimalsCells
    51. da Silva Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley S. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. J Steroid Biochem Mol Biol. 2020 06; 200:105690. PMID: 32408067; PMCID: PMC7397709.
      Citations: 6     Fields:    Translation:AnimalsCells
    52. He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-a expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun. 2020 05 01; 11(1):2165. PMID: 32358493; PMCID: PMC7195451.
      Citations: 18     Fields:    Translation:AnimalsCells
    53. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2076-2083. PMID: 31924743; PMCID: PMC6994990.
      Citations: 15     Fields:    Translation:HumansAnimals
    54. Hua X, Wang YY, Jia P, Xiong Q, Hu Y, Chang Y, Lai S, Xu Y, Zhao Z, Song J. Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression. BMC Med. 2020 01 06; 18(1):2. PMID: 31902369; PMCID: PMC6943904.
      Citations: 23     Fields:    Translation:HumansCells
    55. Zhang W, Wu X, Pei Z, Kiess W, Yang Y, Xu Y, Chang Z, Wu J, Sun C, Luo F. GDF5 Promotes White Adipose Tissue Thermogenesis via p38 MAPK Signaling Pathway. DNA Cell Biol. 2019 Nov; 38(11):1303-1312. PMID: 31553232.
      Citations: 3     Fields:    Translation:AnimalsCells
    56. Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y. A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia. Mol Psychiatry. 2020 05; 25(5):1006-1021. PMID: 31485012; PMCID: PMC7056580.
      Citations: 23     Fields:    Translation:Animals
    57. Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. J Clin Invest. 2019 08 12; 129(9):3786-3791. PMID: 31403469; PMCID: PMC6715359.
      Citations: 29     Fields:    Translation:AnimalsCells
    58. Xu Y, Lu Y, Cassidy RM, Mangieri LR, Zhu C, Huang X, Jiang Z, Justice NJ, Xu Y, Arenkiel BR, Tong Q. Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses. Nat Commun. 2019 08 01; 10(1):3446. PMID: 31371721; PMCID: PMC6671997.
      Citations: 16     Fields:    Translation:AnimalsCells
    59. Mangieri LR, Jiang Z, Lu Y, Xu Y, Cassidy RM, Justice N, Xu Y, Arenkiel BR, Tong Q. Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit. eNeuro. 2019 Jul/Aug; 6(4). PMID: 31331938; PMCID: PMC6664144.
      Citations: 5     Fields:    Translation:AnimalsCells
    60. Cordonier EL, Liu T, Saito K, Chen SS, Xu Y, Fukuda M. Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression. J Endocr Soc. 2019 Jul 01; 3(7):1246-1260. PMID: 31214662; PMCID: PMC6570635.
      Citations: 1     
    61. Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, UK10K Consortium, O'Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 04 12; 10(1):1718. PMID: 30979869; PMCID: PMC6461669.
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    62. Cassidy RM, Lu Y, Jere M, Tian JB, Xu Y, Mangieri LR, Felix-Okoroji B, Selever J, Xu Y, Arenkiel BR, Tong Q. A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues. Sci Adv. 2019 03; 5(3):eaav1640. PMID: 30854429; PMCID: PMC6402846.
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    63. Wang C, Xu Y. Mechanisms for Sex Differences in Energy Homeostasis. J Mol Endocrinol. 2019 02; 62(2):R129-R143. PMID: 31130779; PMCID: PMC6528488.
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    64. Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV, DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019 02; 22(2):205-217. PMID: 30664766; PMCID: PMC6361549.
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    65. Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, Han G, Newell-Fugate A, Tian Y, Majeti R, Liu W, Xu Y, Wu C, Allred K, Allred C, Sun Y, Guo S. Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1. Diabetes. 2019 02; 68(2):291-304. PMID: 30487265; PMCID: PMC6341301.
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    66. Xu Y, L?pez M. Central regulation of energy metabolism by estrogens. Mol Metab. 2018 09; 15:104-115. PMID: 29886181; PMCID: PMC6066788.
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    67. Yu S, Cheng H, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud HR, Fran?ois M, M?nzberg H. Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife. 2018 05 15; 7. PMID: 29761783; PMCID: PMC5953538.
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    68. Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 04 18; 9(1):1544. PMID: 29670083; PMCID: PMC5906443.
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    69. Zhang P, Kuang H, He Y, Idiga SO, Li S, Chen Z, Yang Z, Cai X, Zhang K, Potthoff MJ, Xu Y, Lin JD. NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight. 2018 03 08; 3(5). PMID: 29515030; PMCID: PMC5922292.
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    70. Mangieri LR, Lu Y, Xu Y, Cassidy RM, Xu Y, Arenkiel BR, Tong Q. A neural basis for antagonistic control of feeding and compulsive behaviors. Nat Commun. 2018 01 04; 9(1):52. PMID: 29302029; PMCID: PMC5754347.
      Citations: 21     Fields:    Translation:Animals
    71. Xu J, Zhu C, Zhang M, Tong Q, Wan X, Liao Z, Cai X, Xu Y, Yuan Y, Wang L, Zhu X, Wang S, Gao P, Xi Q, Xu Y, Jiang Q, Shu G. Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway. Metabolism. 2018 02; 79:10-23. PMID: 29080813.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    72. Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR. Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017 Dec; 23(12):1444-1453. PMID: 29106398; PMCID: PMC5720914.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    73. Bai J, Cervantes C, Liu J, He S, Zhou H, Zhang B, Cai H, Yin D, Hu D, Li Z, Chen H, Gao X, Wang F, O'Connor JC, Xu Y, Liu M, Dong LQ, Liu F. DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):12196-12201. PMID: 29087318; PMCID: PMC5699051.
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    74. Zhu C, Xu P, He Y, Yuan Y, Wang T, Cai X, Yu L, Yang L, Wu J, Wang L, Zhu X, Wang S, Gao P, Xi Q, Zhang Y, Xu Y, Jiang Q, Shu G. Heparin Increases Food Intake through AgRP Neurons. Cell Rep. 2017 Sep 05; 20(10):2455-2467. PMID: 28877477; PMCID: PMC6310124.
      Citations: 8     Fields:    Translation:AnimalsCells
    75. Kim ER, Fan S, Akhmedov D, Sun K, Lim H, O'Brien W, Xu Y, Mangieri LR, Zhu Y, Lee CC, Chung Y, Xia Y, Xu Y, Li F, Sun K, Berdeaux R, Tong Q. Red blood cell ?-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724789; PMCID: PMC5518553.
      Citations: 3     Fields:    
    76. Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. 2017 May-Jun; 4(3). PMID: 28560316; PMCID: PMC5446488.
      Citations: 3     Fields:    Translation:AnimalsCells
    77. Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis. Int J Mol Sci. 2017 Apr 14; 18(4). PMID: 28420089; PMCID: PMC5412416.
      Citations: 16     Fields:    Translation:AnimalsCells
    78. Xu Y, O'Malley BW, Elmquist JK. Brain nuclear receptors and body weight regulation. J Clin Invest. 2017 Apr 03; 127(4):1172-1180. PMID: 28218618; PMCID: PMC5373860.
      Citations: 12     Fields:    Translation:HumansAnimals
    79. Xu Y. Brain Estrogens and Feeding Behavior. Adv Exp Med Biol. 2017; 1043:337-357. PMID: 29224102.
      Citations:    Fields:    Translation:HumansAnimalsCells
    80. Hinton AO, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644. PMID: 28006821; PMCID: PMC5179266.
      Citations: 3     Fields:    Translation:Animals
    81. Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Yan X, Hyseni I, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism. 2017 05; 70:152-159. PMID: 28403939; PMCID: PMC5407306.
      Citations: 3     Fields:    Translation:Animals
    82. He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016 11 08; 17(7):1807-1818. PMID: 27829152; PMCID: PMC6248907.
      Citations: 10     Fields:    Translation:AnimalsCells
    83. Kaneko K, Xu P, Cordonier EL, Chen SS, Ng A, Xu Y, Morozov A, Fukuda M. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions. Cell Rep. 2016 09 13; 16(11):3003-3015. PMID: 27626668; PMCID: PMC5024738.
      Citations: 19     Fields:    Translation:AnimalsCells
    84. Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton A, Zhu L, Shu G, Myers MG, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry. 2017 05 01; 81(9):737-747. PMID: 27516377; PMCID: PMC5148733.
      Citations: 37     Fields:    Translation:AnimalsCells
    85. Sisley SR, Arble DM, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA, Chambers AP, Gutierrez-Aguilar R. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488; PMCID: PMC5001188.
      Citations: 17     Fields:    Translation:AnimalsCells
    86. Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba OY, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes. 2016 08; 65(8):2169-78. PMID: 27207529; PMCID: PMC4955988.
      Citations: 35     Fields:    Translation:AnimalsCells
    87. Hu F, Xu Y, Liu F. Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E994-E1002. PMID: 27166282; PMCID: PMC4935144.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    88. Hinton AO, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen Receptor-a in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females. Hypertension. 2016 06; 67(6):1321-30. PMID: 27091896; PMCID: PMC4865414.
      Citations: 5     Fields:    Translation:Animals
    89. Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Sci Rep. 2016 Mar 18; 6:23459. PMID: 26988598; PMCID: PMC4796901.
      Citations: 25     Fields:    Translation:Animals
    90. Meng F, Han Y, Srisai D, Belakhov V, Farias M, Xu Y, Palmiter RD, Baasov T, Wu Q. New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3645-50. PMID: 26976589; PMCID: PMC4822580.
      Citations: 24     Fields:    Translation:AnimalsCells
    91. Xu Y, Chang JT, Myers MG, Xu Y, Tong Q. Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release. Diabetes. 2016 04; 65(4):1040-9. PMID: 26822087; PMCID: PMC4806656.
      Citations: 13     Fields:    Translation:AnimalsCells
    92. Fan S, Dakshinamoorthy J, Kim ER, Xu Y, Huang C, Tong Q. An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide Y. Sci Rep. 2016 Jan 27; 6:19980. PMID: 26813148; PMCID: PMC4728490.
      Citations: 6     Fields:    Translation:AnimalsCells
    93. Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton AO, Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-a-expressing neurons using a new ERa-ZsGreen reporter mouse line. Metabolism. 2016 Apr; 65(4):522-32. PMID: 26975544; PMCID: PMC4794642.
      Citations: 16     Fields:    Translation:AnimalsCells
    94. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425; PMCID: PMC4655219.
      Citations: 23     Fields:    Translation:AnimalsCells
    95. Xu P, Cao X, Xu Y. Targeting brain estrogen receptor for binge eating. Oncotarget. 2015 Sep 15; 6(27):23044-5. PMID: 26309082; PMCID: PMC4695102.
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    96. Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton AO, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates Pro-Opiomelanocortin Neurons in the Arcuate Nucleus. Neuroendocrinology. 2016; 103(5):476-488. PMID: 26337236; PMCID: PMC4767704.
      Citations: 11     Fields:    Translation:AnimalsCells
    97. Kim ER, Wu Z, Sun H, Xu Y, Mangieri LR, Xu Y, Tong Q. Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia. J Neurosci. 2015 Jul 22; 35(29):10440-50. PMID: 26203139; PMCID: PMC4510285.
      Citations: 20     Fields:    Translation:AnimalsCells
    98. Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol. 2015 Jul; 172(14):3510-21. PMID: 25817043; PMCID: PMC4507156.
      Citations: 5     Fields:    Translation:AnimalsCells
    99. Saito K, Cao X, He Y, Xu Y. Progress in the molecular understanding of central regulation of body weight by estrogens. Obesity (Silver Spring). 2015 May; 23(5):919-26. PMID: 25865677; PMCID: PMC4414873.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    100. Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042; PMCID: PMC4430614.
      Citations: 18     Fields:    Translation:Animals
    101. Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci. 2015 Feb 25; 35(8):3312-8. PMID: 25716832; PMCID: PMC4339348.
      Citations: 41     Fields:    Translation:AnimalsCells
    102. Scott MM, Xu Y, Elias CF, Williams KW. Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis. Front Neurosci. 2014; 8:384. PMID: 25520610; PMCID: PMC4253741.
      Citations: 3     
    103. Shu G, Lu NS, Zhu XT, Xu Y, Du MQ, Xie QP, Zhu CJ, Xu Q, Wang SB, Wang LN, Gao P, Xi QY, Zhang YL, Jiang QY. Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo. J Nutr Biochem. 2014 Dec; 25(12):1296-308. PMID: 25283330.
      Citations: 16     Fields:    Translation:AnimalsCells
    104. Xu Y, Kim ER, Fan S, Xia Y, Xu Y, Huang C, Tong Q. Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochem Biophys Res Commun. 2014 Aug 22; 451(2):184-9. PMID: 25065745; PMCID: PMC4162093.
      Citations: 5     Fields:    Translation:Animals
    105. Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest. 2013 Dec; 123(12):5061-70. PMID: 24177424; PMCID: PMC3859401.
      Citations: 88     Fields:    Translation:AnimalsCells
    106. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 02; 18(1):86-98. PMID: 23823479; PMCID: PMC3752162.
      Citations: 37     Fields:    Translation:AnimalsCells
    107. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and ?-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ?-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38. PMID: 23547261; PMCID: PMC3648066.
      Citations: 99     Fields:    Translation:AnimalsCells
    108. Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O'Malley BW, Xu Y, Zhu L. Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology. 2013 Jan; 154(1):150-8. PMID: 23211707; PMCID: PMC3529365.
      Citations: 28     Fields:    Translation:AnimalsCells
    109. Xu Y, Faulkner LD, Hill JW. Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons. Front Endocrinol (Lausanne). 2011; 2:98. PMID: 22649394; PMCID: PMC3355979.
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    110. Xu Y, Elmquist JK, Fukuda M. Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci. 2011 Dec; 1243:1-14. PMID: 22211889; PMCID: PMC3467098.
      Citations: 61     Fields:    Translation:HumansAnimals
    111. Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab. 2011 Oct 05; 14(4):453-65. PMID: 21982706; PMCID: PMC3235745.
      Citations: 267     Fields:    Translation:AnimalsCells
    112. Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 2011 Aug 11; 71(3):488-97. PMID: 21835345; PMCID: PMC3184528.
      Citations: 94     Fields:    Translation:AnimalsCells
    113. Kim KW, Zhao L, Donato J, Kohno D, Xu Y, Elias CF, Lee C, Parker KL, Elmquist JK. Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10673-8. PMID: 21636788; PMCID: PMC3127910.
      Citations: 80     Fields:    Translation:Animals
    114. Kim KW, Sohn JW, Kohno D, Xu Y, Williams K, Elmquist JK. SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis. Mol Cell Endocrinol. 2011 Apr 10; 336(1-2):219-23. PMID: 21111025; PMCID: PMC3057357.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    115. Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci. 2010 Nov 03; 30(44):14630-4. PMID: 21048120; PMCID: PMC3466475.
      Citations: 41     Fields:    Translation:Animals
    116. Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec; 13(12):1457-9. PMID: 21037584; PMCID: PMC3059249.
      Citations: 51     Fields:    Translation:AnimalsCells
    117. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 07; 12(1):88-95. PMID: 20620998; PMCID: PMC2919367.
      Citations: 57     Fields:    Translation:AnimalsCells
    118. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Elmquist JK, Br?ning JC. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010 Apr 07; 11(4):286-97. PMID: 20374961; PMCID: PMC2854520.
      Citations: 191     Fields:    Translation:AnimalsCells
    119. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82. PMID: 19819947; PMCID: PMC2775989.
      Citations: 49     Fields:    Translation:AnimalsCells
    120. Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26; 60(4):582-9. PMID: 19038216; PMCID: PMC2631191.
      Citations: 131     Fields:    Translation:Animals
    121. Xu Y, Krukoff TL. Adrenomedullin stimulates nitric oxide production from primary rat hypothalamic neurons: roles of calcium and phosphatases. Mol Pharmacol. 2007 Jul; 72(1):112-20. PMID: 17446268.
      Citations: 12     Fields:    Translation:AnimalsCells
    122. Xu Y, Krukoff TL. Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A. Br J Pharmacol. 2006 May; 148(1):70-7. PMID: 16501581; PMCID: PMC1617038.
      Citations: 4     Fields:    Translation:Animals
    123. Xu Y, Krukoff TL. Adrenomedullin stimulates nitric oxide release from SK-N-SH human neuroblastoma cells by modulating intracellular calcium mobilization. Endocrinology. 2005 May; 146(5):2295-305. PMID: 15677761.
      Citations: 5     Fields:    Translation:HumansCells
    124. Xu Y, Krukoff TL. Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA. Regul Pept. 2004 Jun 15; 119(1-2):21-30. PMID: 15093693; PMCID: PMC4820401.
      Citations: 8     Fields:    Translation:AnimalsCells
    125. Xu Y, Krukoff TL. Adrenomedullin in the rostral ventrolateral medulla increases arterial pressure and heart rate: roles of glutamate and nitric oxide. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R729-34. PMID: 15178541; PMCID: PMC4820402.
      Citations: 9     Fields:    Translation:AnimalsCells
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