"Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
| Descriptor ID |
D008025
|
| MeSH Number(s) |
D08.811.464
|
| Concept/Terms |
Ligases- Ligases
- Synthetases
- Synthetase
|
Below are MeSH descriptors whose meaning is more general than "Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ligases".
This graph shows the total number of publications written about "Ligases" by people in this website by year, and whether "Ligases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 2 | 4 |
| 1999 | 5 | 0 | 5 |
| 2000 | 2 | 1 | 3 |
| 2001 | 2 | 2 | 4 |
| 2002 | 2 | 1 | 3 |
| 2003 | 3 | 0 | 3 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ligases" by people in Profiles.
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Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects. Brain. 2023 04 19; 146(4):1373-1387.
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EntE, EntS and TolC synergistically contributed to the pathogenesis of APEC strain E058. Microb Pathog. 2020 Apr; 141:103990.
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Risk Haplotypes Uniquely Associated with Radioiodine-Refractory Thyroid Cancer Patients of High African Ancestry. Thyroid. 2019 04; 29(4):530-539.
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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Rep. 2016 08 09; 16(6):1614-1628.
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A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar; 12(3):180-7.
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Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis. J Med Chem. 2015 Jul 23; 58(14):5459-75.
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Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid Redox Signal. 2014 Dec 10; 21(17):2383-400.
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Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites. ACS Chem Biol. 2013 Jul 19; 8(7):1549-57.
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ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011 Nov 11; 147(4):773-88.
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WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev. 2008 Apr 01; 22(7):866-71.