Last Name


TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH. The constitutive lipid droplet protein PLIN2 regulates autophagy in liver. Autophagy. 2017 May 26; 1-15. PMID: 28548876.
      View in: PubMed
    2. Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD. Hepatic FXR/SHP Axis Modulates Systemic Glucose and Fatty Acid Homeostasis in Aged Mice. Hepatology. 2017 Apr 05. PMID: 28378930.
      View in: PubMed
    3. Chen E, Tsai TH, Li L, Saha P, Chan L, Chang BH. PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic ß Cells. Sci Rep. 2017 Jan 19; 7:40855. PMID: 28102311.
      View in: PubMed
    4. Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR. Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21; 165(3):566-79. PMID: 27087445; PMCID: PMC4852710 [Available on 04/21/17].
    5. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ER?-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425.
      View in: PubMed
    6. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HC, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015; 6:7339. PMID: 26081744.
      View in: PubMed
    7. Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-3548. PMID: 25953849.
      View in: PubMed
    8. Chen W, Zhou H, Saha P, Li L, Chan L. Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology. 2014 Nov; 155(11):4215-25. PMID: 25093462; PMCID: PMC4197977.
    9. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and ?-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ?-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38. PMID: 23547261; PMCID: PMC3648066.
    10. Lacaria M, Saha P, Potocki L, Bi W, Yan J, Girirajan S, Burns B, Elsea S, Walz K, Chan L, Lupski JR, Gu W. A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men. PLoS Genet. 2012; 8(5):e1002713. PMID: 22654670; PMCID: PMC3359973.
    11. Poungvarin N, Lee JK, Yechoor VK, Li MV, Assavapokee T, Suksaranjit P, Thepsongwajja JJ, Saha PK, Oka K, Chan L. Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity. Diabetologia. 2012 Jun; 55(6):1783-96. PMID: 22382520; PMCID: PMC4010252.
    12. Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, Wen S, Tian M, Ma J, Kolonin MG, Saha PK, Do KA, Hulvat JF, Gelovani JG, Chan L, Arap W, Pasqualini R. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011 Nov 9; 3(108):108ra112. PMID: 22072637; PMCID: PMC3666164.
    13. Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y. Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell. 2011 Dec; 10(6):996-1010. PMID: 21895961; PMCID: PMC3215833.
    14. Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab. 2011 Jan 5; 13(1):35-43. PMID: 21195347; PMCID: PMC3072049.
    15. Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab. 2010 Dec 1; 12(6):606-18. PMID: 21109193; PMCID: PMC3024581.
    16. Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J Biol Chem. 2010 Dec 24; 285(52):40581-92. PMID: 20956520; PMCID: PMC3003357.
    17. Chang BH, Li L, Saha P, Chan L. Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J Lipid Res. 2010 Aug; 51(8):2132-42. PMID: 20424269; PMCID: PMC2903828.
    18. Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 7; 395(3):395-400. PMID: 20382127; PMCID: PMC2874883.
    19. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18831-6. PMID: 19850873; PMCID: PMC2773998.
    20. Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 2009 Jan 7; 9(1):77-87. PMID: 19117548; PMCID: PMC2630393.
    21. Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19229-34. PMID: 19047629; PMCID: PMC2614744.
    22. Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28; 322(5906):1395-9. PMID: 19039140; PMCID: PMC2668604.
    23. Gupta S, Saha PK, Mukhopadhyay A. Prevalence of hypothyroidism and importance of cholesterol estimation in patients suffering from major depressive disorder. J Indian Med Assoc. 2008 Apr; 106(4):240, 242. PMID: 18828343.
      View in: PubMed
    24. Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology. 2007 Jul; 46(1):147-57. PMID: 17526026.
      View in: PubMed
    25. De J, Mukhopadhyay A, Saha PK. Study of serum lipid profile in pregnancy induced hypertension. Indian J Clin Biochem. 2006 Sep; 21(2):165-8. PMID: 23105637; PMCID: PMC3453987.
    26. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2006 Nov; 20(11):2671-81. PMID: 16803864.
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    27. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 2006 May; 3(5):379-86. PMID: 16679295.
      View in: PubMed
    28. Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr; 116(4):1102-9. PMID: 16557297; PMCID: PMC1409738.
    29. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005 Oct; 2(4):227-38. PMID: 16213225.
      View in: PubMed
    30. Saha PK, Kojima H, Martinez-Botas J, Sunehag AL, Chan L. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem. 2004 Aug 20; 279(34):35150-8. PMID: 15197189.
      View in: PubMed
    31. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004 Jun; 10(6):625-32. PMID: 15133506.
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    32. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74. PMID: 14578284.
      View in: PubMed
    33. Sharma SK, Balamurugan A, Saha PK, Pandey RM, Mehra NK. Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med. 2002 Oct 1; 166(7):916-9. PMID: 12359646.
      View in: PubMed
    34. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH, Paul A, Chan L. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20; 277(38):34658-61. PMID: 12151381.
      View in: PubMed
    35. Guhathakurta B, Sasmal D, Ghosh AN, Kumar R, Saha P, Biswas D, Khetawat D, Datta A. Adhesion and invasion of a mutant Shigella flexneri to an eukaryotic cell line in absence of the 220-kb virulence plasmid. FEMS Microbiol Lett. 1999 Dec 15; 181(2):267-75. PMID: 10585548.
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    36. Basu I, Mitra R, Saha PK, Ghosh AN, Bhattacharya J, Chakrabarti MK, Takeda Y, Nair GB. Morphological and cytoskeletal changes caused by non-membrane damaging cytotoxin of Vibrio cholerae on int 407 and HeLa cells. FEMS Microbiol Lett. 1999 Oct 15; 179(2):255-63. PMID: 10518724.
      View in: PubMed
    37. Pal A, Saha PK, Nair GB, Yamasaki S, Takeda T, Takeda Y, Bhattacharya SK, Ramamurthy T. Clonal analysis of non-toxigenic Vibrio cholerae O1 associated with an outbreak of cholera. Indian J Med Res. 1999 Jun; 109:208-11. PMID: 10491912.
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    38. Koley H, Mitra R, Basu A, Mukhopadhyay AK, Saha PK, Ramakrishna BS, Krishnan S, Takeda Y, Nair GB. Response of wild-type mutants of Vibrio cholerae O1 possessing different combinations of virulence genes in the ligated rabbit ileal loop and in Ussing chambers: evidence for the presence of additional secretogen. J Med Microbiol. 1999 Jan; 48(1):51-7. PMID: 9920125.
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    39. Mitra R, Saha PK, Basu I, Venkataraman A, Ramakrishna BS, Albert MJ, Takeda Y, Nair GB. Characterization of non-membrane-damaging cytotoxin of non-toxigenic Vibrio cholerae O1 and its relevance to disease. FEMS Microbiol Lett. 1998 Dec 15; 169(2):331-9. PMID: 9868778.
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    40. Saha PK, Nair GB. Production of monoclonal antibodies to the non-membrane-damaging cytotoxin (NMDCY) purified from Vibrio cholerae O26 and distribution of NMDCY among strains of Vibrio cholerae and other enteric bacteria determined by monoclonal-polyclonal sandwich enzyme-linked immunosorbent assay. Infect Immun. 1997 Feb; 65(2):801-5. PMID: 9009346; PMCID: PMC176129.
    41. Saha PK, Koley H, Nair GB. Purification and characterization of an extracellular secretogenic non-membrane-damaging cytotoxin produced by clinical strains of Vibrio cholerae non-O1. Infect Immun. 1996 Aug; 64(8):3101-8. PMID: 8757840; PMCID: PMC174194.
    42. Mukhopadhyay AK, Garg S, Saha PK, Takeda Y, Bhattacharya SK, Nair GB. Comparative analysis of factors promoting optimal production of cholera toxin by Vibrio cholerae O1 (classical & E1Tor biotypes) & O139. Indian J Med Res. 1996 Jul; 104:129-33. PMID: 8783515.
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    43. Mukhopadhyay AK, Saha PK, Garg S, Bhattacharya SK, Shimada T, Takeda T, Takeda Y, Nair GB. Distribution and virulence of Vibrio cholerae belonging to serogroups other than O1 and O139: a nationwide survey. Epidemiol Infect. 1995 Feb; 114(1):65-70. PMID: 7867744; PMCID: PMC2271350.
    44. Garg S, Saha PK, Ramamurthy T, Deb BC, Nair GB, Shimada T, Takeda Y. Nationwide prevalence of the new epidemic strain of Vibrio cholerae O139 Bengal in India. J Infect. 1993 Jul; 27(1):108-9. PMID: 8370938.
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    45. Bhattacharya SK, Bhattacharya MK, Nair GB, Dutta D, Deb A, Ramamurthy T, Garg S, Saha PK, Dutta P, Moitra A, et al. Clinical profile of acute diarrhoea cases infected with the new epidemic strain of Vibrio cholerae O139: designation of the disease as cholera. J Infect. 1993 Jul; 27(1):11-5. PMID: 8370939.
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    46. Bhattacharya MK, Bhattacharya SK, Garg S, Saha PK, Dutta D, Nair GB, Deb BC, Das KP. Outbreak of Vibrio cholerae non-O1 in India and Bangladesh. Lancet. 1993 May 22; 341(8856):1346-7. PMID: 8098474.
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