ATP Citrate (pro-S)-Lyase
"ATP Citrate (pro-S)-Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
| Descriptor ID |
D001275
|
| MeSH Number(s) |
D08.811.913.050.331
|
| Concept/Terms |
ATP Citrate (pro-S)-Lyase- ATP Citrate (pro-S)-Lyase
- Citrate Cleavage Enzyme
- Cleavage Enzyme, Citrate
- ATP Citrate Synthase
- Citrate Synthase, ATP
- Synthase, ATP Citrate
- ATP-Dependent Citrate Lyase
- ATP Dependent Citrate Lyase
- Citrate Lyase, ATP-Dependent
- Lyase, ATP-Dependent Citrate
- ATP Citrate (pro-3S)-Lyase
- ATP Citrate Lyase
- Citrate Lyase, ATP
- Lyase, ATP Citrate
|
Below are MeSH descriptors whose meaning is more general than "ATP Citrate (pro-S)-Lyase".
Below are MeSH descriptors whose meaning is more specific than "ATP Citrate (pro-S)-Lyase".
This graph shows the total number of publications written about "ATP Citrate (pro-S)-Lyase" by people in this website by year, and whether "ATP Citrate (pro-S)-Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 1 | 2 |
| 2016 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "ATP Citrate (pro-S)-Lyase" by people in Profiles.
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Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice. J Biol Chem. 2022 10; 298(10):102401.
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Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street. Mol Metab. 2021 10; 52:101261.
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Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol. N Engl J Med. 2019 03 14; 380(11):1022-1032.
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metab. 2018 Jun 05; 27(6):1281-1293.e7.
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Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase. Curr Atheroscler Rep. 2016 10; 18(10):61.
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Oncometabolite d-2-hydroxyglutarate impairs a-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):10436-41.
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Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells. Cancer Res. 2016 04 15; 76(8):2406-18.
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ATP citrate lyase mediates resistance of colorectal cancer cells to SN38. Mol Cancer Ther. 2013 Dec; 12(12):2782-91.
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Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. J Am Coll Cardiol. 2013 Sep 24; 62(13):1154-62.