Phosphatidylcholine-Sterol O-Acyltransferase
"Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
| Descriptor ID |
D007862
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| MeSH Number(s) |
D08.811.913.050.625
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| Concept/Terms |
Phosphatidylcholine-Sterol O-Acyltransferase- Phosphatidylcholine-Sterol O-Acyltransferase
- O-Acyltransferase, Phosphatidylcholine-Sterol
- Phosphatidylcholine Sterol O Acyltransferase
- Lecithin Cholesterol Acyltransferase
- Acyltransferase, Lecithin Cholesterol
- Cholesterol Acyltransferase, Lecithin
- Lecithin Acyltransferase
- Acyltransferase, Lecithin
- Cholesterol Ester Lysolecithin Acyltransferase
- Phosophatidylcholine-Sterol Acyltransferase
- Acyltransferase, Phosophatidylcholine-Sterol
- Phosophatidylcholine Sterol Acyltransferase
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylcholine-Sterol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylcholine-Sterol O-Acyltransferase".
This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in this website by year, and whether "Phosphatidylcholine-Sterol O-Acyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles.
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Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice. J Biol Chem. 2011 Apr 15; 286(15):13079-87.
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Isoform analysis of LC-MS/MS data from multidimensional fractionation of the serum proteome. J Proteome Res. 2008 Jun; 7(6):2546-52.
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Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):149-54.
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Molecular basis of fish-eye disease in a patient from Spain. Characterization of a novel mutation in the LCAT gene and lipid analysis of the cornea. Arterioscler Thromb Vasc Biol. 1997 Jul; 17(7):1382-91.
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Plasma lipid transport in the hedgehog: partial characterization of structure and function of apolipoprotein A-I. J Lipid Res. 1995 Mar; 36(3):485-95.
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Lipoprotein-X: a substrate for lecithin: cholesterol acyltransferase. Eur J Clin Invest. 1977 Jun; 7(3):213-7.
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Lipoprotein structure and metabolism. Physiol Rev. 1976 Apr; 56(2):259-316.