Hydroxymethylglutaryl-CoA Synthase
"Hydroxymethylglutaryl-CoA Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
| Descriptor ID |
D006904
|
| MeSH Number(s) |
D08.811.913.050.612
|
| Concept/Terms |
Hydroxymethylglutaryl-CoA Synthase- Hydroxymethylglutaryl-CoA Synthase
- Hydroxymethylglutaryl CoA Synthase
- Synthase, Hydroxymethylglutaryl-CoA
- 3-hydroxy-3-methylglutaryl-coenzyme A synthase
- HMG-CoA synthase
|
Below are MeSH descriptors whose meaning is more general than "Hydroxymethylglutaryl-CoA Synthase".
Below are MeSH descriptors whose meaning is more specific than "Hydroxymethylglutaryl-CoA Synthase".
This graph shows the total number of publications written about "Hydroxymethylglutaryl-CoA Synthase" by people in this website by year, and whether "Hydroxymethylglutaryl-CoA Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hydroxymethylglutaryl-CoA Synthase" by people in Profiles.
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Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019 08 22; 178(5):1115-1131.e15.
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The isomiR-140-3p-regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancer. Breast Cancer Res. 2018 12 11; 20(1):150.
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Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients. J Am Heart Assoc. 2018 03 09; 7(6).
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Effect of Brain Tumor Presence During Radiation on Tissue Toxicity: Transcriptomic and Metabolic Changes. Int J Radiat Oncol Biol Phys. 2017 11 15; 99(4):983-993.
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Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Infect Dis. 2011 Aug 15; 204(4):609-16.
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The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. Mol Endocrinol. 2007 Oct; 21(10):2361-77.