5-Aminolevulinate Synthetase
"5-Aminolevulinate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
| Descriptor ID |
D000624
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| MeSH Number(s) |
D08.811.913.050.276
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| Concept/Terms |
5-Aminolevulinate Synthetase- 5-Aminolevulinate Synthetase
- 5 Aminolevulinate Synthetase
- Synthetase, 5-Aminolevulinate
- delta-Aminolevulinate Synthase
- Synthase, delta-Aminolevulinate
- delta Aminolevulinate Synthase
- 5-Aminolevulinate Synthase
- 5 Aminolevulinate Synthase
- Synthase, 5-Aminolevulinate
- Aminolevulinic Acid Synthetase
- Acid Synthetase, Aminolevulinic
- Synthetase, Aminolevulinic Acid
- delta-Aminolevulinic Acid Synthetase
- Acid Synthetase, delta-Aminolevulinic
- Synthetase, delta-Aminolevulinic Acid
- delta Aminolevulinic Acid Synthetase
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Below are MeSH descriptors whose meaning is more general than "5-Aminolevulinate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "5-Aminolevulinate Synthetase".
This graph shows the total number of publications written about "5-Aminolevulinate Synthetase" by people in this website by year, and whether "5-Aminolevulinate Synthetase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "5-Aminolevulinate Synthetase" by people in Profiles.
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Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G. Acta Haematol. 2008; 120(3):168-73.
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Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene. Gene. 2000 Apr 18; 247(1-2):153-66.
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Rhodanese and ALA-S in mammary tumor and liver from normal and tumor-bearing mice. Comp Biochem Physiol B. 1992 May; 102(1):83-5.
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The effect of griseofulvin on the heme pathway--II. An exhaustive analysis during short and long-term challenge. Gen Pharmacol. 1991; 22(6):1179-83.
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Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice--I. Effect of allyl-isopropylacetamide and veronal on delta-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase. Int J Biochem. 1990; 22(9):1005-8.
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In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway. Gen Pharmacol. 1990; 21(4):423-6.