"Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.
| Descriptor ID |
D002785
|
| MeSH Number(s) |
D08.811.913.050.799
|
| Concept/Terms |
Sterol O-Acyltransferase- Sterol O-Acyltransferase
- O-Acyltransferase, Sterol
- Sterol O Acyltransferase
- Cholesterol Esterifying Enzyme
- Enzyme, Cholesterol Esterifying
- Esterifying Enzyme, Cholesterol
- Acyl-CoA-Cholesterol Acyltransferase
- Acyl CoA Cholesterol Acyltransferase
- Acyltransferase, Acyl-CoA-Cholesterol
- Cholesterol Acyltransferase
- Acyltransferase, Cholesterol
|
Below are MeSH descriptors whose meaning is more general than "Sterol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Sterol O-Acyltransferase".
This graph shows the total number of publications written about "Sterol O-Acyltransferase" by people in this website by year, and whether "Sterol O-Acyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sterol O-Acyltransferase" by people in Profiles.
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A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma. Invest New Drugs. 2020 10; 38(5):1421-1429.
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Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity. Stem Cells. 2018 10; 36(10):1603-1616.
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Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2748-53.
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Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem. 1995 Nov 03; 270(44):26192-201.
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Cholesterol metabolism in hypercholesterolemia-resistant rabbits. Atherosclerosis. 1991 Apr; 87(2-3):169-81.
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Cholesterol metabolism in fibroblasts from rabbits resistant to diet-induced hypercholesterolemia. J Lipid Res. 1990 Jun; 31(6):985-94.
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Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one. J Lipid Res. 1989 Feb; 30(2):247-61.