Adenosine Deaminase Inhibitors

"Adenosine Deaminase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Drugs that inhibit ADENOSINE DEAMINASE activity.

Descriptor ID	D058892
MeSH Number(s)	D27.505.519.389.092
Concept/Terms	Adenosine Deaminase Inhibitors Adenosine Deaminase Inhibitors Deaminase Inhibitors, Adenosine Inhibitors, Adenosine Deaminase ADA Inhibitors Inhibitors, ADA

Below are MeSH descriptors whose meaning is more general than "Adenosine Deaminase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Adenosine Deaminase Inhibitors [D27.505.519.389.092]

Below are MeSH descriptors whose meaning is related to "Adenosine Deaminase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Adenosine Deaminase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Adenosine Deaminase Inhibitors" by people in this website by year, and whether "Adenosine Deaminase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 1996 and 1998 and 2010 and 2012 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1998	1	0	1
2010	1	0	1
2012	0	1	1
2013	0	1	1

Below are the most recent publications written about "Adenosine Deaminase Inhibitors" by people in Profiles.

Lu Q, Sakhatskyy P, Newton J, Shamirian P, Hsiao V, Curren S, Gabino Miranda GA, Pedroza M, Blackburn MR, Rounds S. Sustained adenosine exposure causes lung endothelial apoptosis: a possible contributor to cigarette smoke-induced endothelial apoptosis and lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 01; 304(5):L361-70.

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Lu Q, Newton J, Hsiao V, Shamirian P, Blackburn MR, Pedroza M. Sustained adenosine exposure causes lung endothelial barrier dysfunction via nucleoside transporter-mediated signaling. Am J Respir Cell Mol Biol. 2012 Nov; 47(5):604-13.

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Parmar S, Andersson BS, Couriel D, Munsell MF, Fernandez-Vina M, Jones RB, Shpall EJ, Popat U, Anderlini P, Giralt S, Alousi A, Cano P, Bosque D, Hosing C, Silva Lde P, Westmoreland M, Wathen JK, Berry D, Champlin RE, de Lima MJ. Prophylaxis of graft-versus-host disease in unrelated donor transplantation with pentostatin, tacrolimus, and mini-methotrexate: a phase I/II controlled, adaptively randomized study. J Clin Oncol. 2011 Jan 20; 29(3):294-302.

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Wang Z, Quiocho FA. Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity. Biochemistry. 1998 Jun 09; 37(23):8314-24.

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Marrone TJ, Straatsma TP, Briggs JM, Wilson DK, Quiocho FA, McCammon JA. Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin. J Med Chem. 1996 Jan 05; 39(1):277-84.

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Ingolia DE, Yeung CY, Orengo IF, Harrison ML, Frayne EG, Rudolph FB, Kellems RE. Purification and characterization of adenosine deaminase from a genetically enriched mouse cell line. J Biol Chem. 1985 Oct 25; 260(24):13261-7.

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Plunkett W. Inhibition of adenosine deaminase to increase the antitumor activity of adenine nucleoside analogues. Ann N Y Acad Sci. 1985; 451:150-9.

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Shewach DS, Plunkett W. Effect of 2'-deoxycoformycin on the inhibition of deoxyribonucleic acid synthesis by 9-beta-D-arabinofuranosyladenine 5'-triphosphate. Biochem Pharmacol. 1982 Jun 01; 31(11):2103-9.

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Poplack DG, Sallan SE, Rivera G, Holcenberg J, Murphy SB, Blatt J, Lipton JM, Venner P, Glaubiger DL, Ungerleider R, Johns D. Phase I study of 2'-deoxycoformycin in acute lymphoblastic leukemia. Cancer Res. 1981 Sep; 41(9 Pt 1):3343-6.

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Plunkett W, Chubb S, Alexander L, Montgomery JA. Comparison of the toxicity and metabolism of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine in human lymphoblastoid cells. Cancer Res. 1980 Jul; 40(7):2349-55.

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