TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    U24DK097748     (O'MALLEY, BERT W)Sep 17, 2012 - Aug 31, 2019
    A Hub for the Nuclear Receptor Signaling Atlas1
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Seasock MJ, Shafiquzzaman M, Ruiz-Echartea ME, Kanchi RS, Tran BT, Simon LM, Meyer MD, Erice PA, Lotlikar SL, Wenlock SC, Ochsner SA, Enright A, Carisey AF, Romero F, Rosas IO, King KY, McKenna NJ, Coarfa C, Rodriguez A. Let-7 restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis. bioRxiv. 2024 May 27. PMID: 38826218; PMCID: PMC11142151.
    2. Taylor BC, Steinthal LH, Dias M, Yalamanchili HK, Ochsner SA, Zapata GE, Mehta NR, McKenna NJ, Young NL, Nuotio-Antar AM. Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress. Epigenetics Chromatin. 2024 Apr 27; 17(1):12. PMID: 38678237; PMCID: PMC11055387.
      Citations:    Fields:    Translation:AnimalsCells
    3. Taylor BC, Steinthal LH, Dias M, Yalamanchili HK, Ochsner SA, Zapata GE, Mehta NR, McKenna NJ, Young NL, Nuotio-Antar AM. Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress. bioRxiv. 2024 Jan 22. PMID: 38328142; PMCID: PMC10849524.
    4. Rojas-Quintero J, Ochsner SA, New F, Divakar P, Yang CX, Wu TD, Robinson J, Chandrashekar DS, Banovich NE, Rosas IO, Sauler M, Kheradmand F, Gaggar A, Margaroli C, San Jose Estepar R, McKenna NJ, Polverino F. Spatial Transcriptomics Resolve an Emphysema-Specific Lymphoid Follicle B Cell Signature in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2024 Jan 01; 209(1):48-58. PMID: 37934672; PMCID: PMC10870877.
      Citations:    Fields:    Translation:Humans
    5. Rojas-Quintero J, Ochsner SA, New F, Divakar P, Yang CX, Wu TD, Robinson J, Shimoga Chandrashekar D, Banovich NE, Rosas IO, Sauler M, Kheradmand F, Gaggar A, Margaroli C, San Jose Estepar R, McKenna NJ, Polverino F. Spatial Transcriptomics Resolve an Emphysema-specific Lymphoid Follicle B Cell Signature in COPD. Am J Respir Crit Care Med. 2023 Dec 08. PMID: 38064378.
      Citations:    Fields:    
    6. Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ, Hengstschl?ger M. SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells. Sci Transl Med. 2023 09 13; 15(713):eade2581. PMID: 37703351; PMCID: PMC11126869.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Masschelin PM, Saha P, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar AM, Sun Z, Kaipparettu BA, Putluri N, Moore DD, Summers SA, McKenna NJ, Hartig SM. Vitamin B2 enables regulation of fasting glucose availability. Elife. 2023 Jul 07; 12. PMID: 37417957; PMCID: PMC10328530.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Ochsner SA, Pedroza M, Pillich RT, Krishnan V, Konicek BW, Dow ER, Park SY, Agarwal SK, McKenna NJ. IL17A Blockade with Ixekizumab Suppresses MuvB Signaling in Clinical Psoriasis. J Invest Dermatol. 2023 09; 143(9):1689-1699. PMID: 36967086.
      Citations:    Fields:    Translation:Humans
    9. Ochsner SA, Pillich RT, Rawool D, Grethe JS, McKenna NJ. Transcriptional regulatory networks of circulating immune cells in type 1 diabetes: A community knowledgebase. iScience. 2022 Jul 15; 25(7):104581. PMID: 35832893; PMCID: PMC9272393.
    10. Chen KY, De Angulo A, Guo X, More A, Ochsner SA, Lopez E, Saul D, Pang W, Sun Y, McKenna NJ, Tong Q. Adipocyte-Specific Ablation of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome in Aging Mice. Front Aging. 2021; 2:803482. PMID: 35822007; PMCID: PMC9261351.
    11. Campden RI, Warren AL, Greene CJ, Chiriboga JA, Arnold CR, Aggarwal D, McKenna N, Sandall CF, MacDonald JA, Yates RM. Extracellular cathepsin Z signals through the a5 integrin and augments NLRP3 inflammasome activation. J Biol Chem. 2022 01; 298(1):101459. PMID: 34864055; PMCID: PMC8753182.
    12. Zapata RC, Chaudry BS, Valencia ML, Zhang D, Ochsner SA, McKenna NJ, Osborn O. Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain. Transl Psychiatry. 2021 07 22; 11(1):405. PMID: 34294678; PMCID: PMC8296828.
      Citations:    Fields:    Translation:HumansAnimals
    13. Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281. PMID: 34036256; PMCID: PMC8138774.
      Citations: 6     
    14. Nikolai BC, Jain P, Cardenas DL, York B, Feng Q, McKenna NJ, Dasgupta S, Lonard DM, O'Malley BW. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441. PMID: 33564037; PMCID: PMC7873281.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    15. Ochsner SA, Pillich RT, McKenna NJ. Consensus transcriptional regulatory networks of coronavirus-infected human cells. Sci Data. 2020 09 22; 7(1):314. PMID: 32963239; PMCID: PMC7509801.
      Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
    16. Ochsner SA, Pillich RT, McKenna NJ. Consensus transcriptional regulatory networks of coronavirus-infected human cells. bioRxiv. 2020 Jul 15. PMID: 32511379; PMCID: PMC7263508.
    17. Ochsner SA, McKenna NJ. No Dataset Left Behind: Mechanistic Insights into Thyroid Receptor Signaling Through Transcriptomic Consensome Meta-Analysis. Thyroid. 2020 04; 30(4):621-639. PMID: 31910096; PMCID: PMC7187985.
      Citations:    Fields:    Translation:HumansCells
    18. Ochsner SA, Abraham D, Martin K, Ding W, McOwiti A, Kankanamge W, Wang Z, Andreano K, Hamilton RA, Chen Y, Hamilton A, Gantner ML, Dehart M, Qu S, Hilsenbeck SG, Becnel LB, Bridges D, Ma'ayan A, Huss JM, Stossi F, Foulds CE, Kralli A, McDonnell DP, McKenna NJ. The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways. Sci Data. 2019 10 31; 6(1):252. PMID: 31672983; PMCID: PMC6823428.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    19. Jagodnik KM, Koplev S, Jenkins SL, Ohno-Machado L, Paten B, Schurer SC, Dumontier M, Verborgh R, Bui A, Ping P, McKenna NJ, Madduri R, Pillai A, Ma'ayan A. Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop. J Biomed Inform. 2017 07; 71:49-57. PMID: 28501646; PMCID: PMC5545976.
      Citations: 14     Fields:    Translation:Humans
    20. Becnel LB, Ochsner SA, Darlington YF, McOwiti A, Kankanamge WH, Dehart M, Naumov A, McKenna NJ. Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in Transcriptomine. Sci Signal. 2017 Apr 25; 10(476). PMID: 28442630.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    21. Darlington YF, Naumov A, McOwiti A, Kankanamge WH, Becnel LB, McKenna NJ. Improving the discoverability, accessibility, and citability of omics datasets: a case report. J Am Med Inform Assoc. 2017 03 01; 24(2):388-393. PMID: 27413121; PMCID: PMC7651888.
      Citations: 2     Fields:    Translation:HumansCells
    22. Ochsner SA, Tsimelzon A, Dong J, Coarfa C, McKenna NJ. Research Resource: A Reference Transcriptome for Constitutive Androstane Receptor and Pregnane X Receptor Xenobiotic Signaling. Mol Endocrinol. 2016 Aug; 30(8):937-48. PMID: 27409825; PMCID: PMC4965847.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    23. McKenna NJ. Research Resources for Nuclear Receptor Signaling Pathways. Mol Pharmacol. 2016 Aug; 90(2):153-9. PMID: 27216565; PMCID: PMC4959089.
      Citations: 1     Fields:    Translation:HumansCells
    24. Becnel LB, Darlington YF, Ochsner SA, Easton-Marks JR, Watkins CM, McOwiti A, Kankanamge WH, Wise MW, DeHart M, Margolis RN, McKenna NJ. Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways. PLoS One. 2015; 10(9):e0135615. PMID: 26325041; PMCID: PMC4556694.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. McKenna NJ, Evans RM, O'Malley BW. Nuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research. Nucl Recept Signal. 2014; 12:e006. PMID: 25614732; PMCID: PMC4303009.
      Citations: 7     Fields:    Translation:Cells
    26. Balce DR, Allan ERO, McKenna N, Yates RM. ?-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages. J Biol Chem. 2014 Nov 14; 289(46):31891-31904. PMID: 25253686; PMCID: PMC4231668.
    27. Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B. Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun. 2013 May 03; 434(2):357-62. PMID: 23567971; PMCID: PMC3763992.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    28. Defranco DB, Margolis R, McKenna N. Editorial: molecular endocrinology articles in the spotlight for October 2012. Mol Endocrinol. 2012 Oct; 26(10):1645. PMID: 23023930; PMCID: PMC5416957.
      Citations:    Fields:    Translation:Humans
    29. Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA. Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. Chem Biol. 2012 Sep 21; 19(9):1126-41. PMID: 22999881; PMCID: PMC4259876.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    30. Khalaf H, Ochsner SA, Sreenivasan R, Koskinen J, Karlsson M, Karlsson J, McKenna NJ, Olsson PE, Pradhan A, Orb?n L. Activation of NF-?B protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. J Biol Chem. 2012 Nov 02; 287(45):37926-38. PMID: 22988238; PMCID: PMC3488064.
      Citations: 16     Fields:    Translation:AnimalsCells
    31. Becnel LB, McKenna NJ. Minireview: progress and challenges in proteomics data management, sharing, and integration. Mol Endocrinol. 2012 Oct; 26(10):1660-74. PMID: 22902541; PMCID: PMC3458223.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    32. Ochsner SA, Watkins CM, McOwiti A, Xu X, Darlington YF, Dehart MD, Cooney AJ, Steffen DL, Becnel LB, McKenna NJ. Transcriptomine, a web resource for nuclear receptor signaling transcriptomes. Physiol Genomics. 2012 Sep 01; 44(17):853-63. PMID: 22786849; PMCID: PMC3472459.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    33. McKenna NJ, Howard CL, Aufiero M, Easton-Marks J, Steffen DL, Becnel LB, Magnuson MA, McIndoe RA, Cartailler JP. Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia. Mol Endocrinol. 2012 Oct; 26(10):1675-81. PMID: 22734043; PMCID: PMC3458218.
      Citations: 1     Fields:    Translation:HumansAnimals
    34. McKenna NJ. EMBO Retinoids 2011: Mechanisms, biology and pathology of signaling by retinoic acid and retinoic acid receptors. Nucl Recept Signal. 2012; 10:e003. PMID: 22438793; PMCID: PMC3309077.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    35. Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest. 2011 Jan; 121(1):86-95. PMID: 21123943; PMCID: PMC3007143.
      Citations: 54     Fields:    Translation:HumansAnimals
    36. McKenna NJ. Discovery-driven research and bioinformatics in nuclear receptor and coregulator signaling. Biochim Biophys Acta. 2011 Aug; 1812(8):808-17. PMID: 21029773; PMCID: PMC3609546.
      Citations: 3     Fields:    Translation:HumansCells
    37. McKenna NJ, O'Malley BW. SnapShot: NR coregulators. Cell. 2010 Oct 01; 143(1):172-172.e1. PMID: 20887900.
      Citations: 7     Fields:    Translation:HumansAnimals
    38. McKenna NJ, O'Malley BW. SnapShot: Nuclear receptors II. Cell. 2010 Sep 17; 142(6):986.e1. PMID: 20850017.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    39. McKenna NJ, O'Malley BW. SnapShot: Nuclear receptors I. Cell. 2010 Sep 03; 142(5):822-822.e1. PMID: 20813267.
      Citations: 7     Fields:    Translation:HumansAnimals
    40. Ochsner SA, Watkins CM, LaGrone BS, Steffen DL, McKenna NJ. Research resource: Tissue-specific transcriptomics and cistromics of nuclear receptor signaling: a web research resource. Mol Endocrinol. 2010 Oct; 24(10):2065-9. PMID: 20685849; PMCID: PMC2954640.
      Citations: 2     Fields:    Translation:AnimalsCells
    41. DeFranco DB, McKenna NJ. Signals from NURSA. Mol Endocrinol. 2009 Dec; 23(12):1939. PMID: 19934347; PMCID: PMC5419130.
      Citations:    Fields:    
    42. McKenna NJ, DeFranco DB. Molecular endocrinology: A portal for enhanced access and utility of the nuclear receptor signaling atlas (NURSA) web resource. Mol Endocrinol. 2009 Jun; 23(6):739. PMID: 19470797; PMCID: PMC2691678.
      Citations:    Fields:    Translation:Cells
    43. McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol. 2009 Jun; 23(6):740-6. PMID: 19423650; PMCID: PMC2691684.
      Citations: 61     Fields:    Translation:Cells
    44. Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA. Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype. J Biol Chem. 2009 Apr 03; 284(14):9458-64. PMID: 19136559; PMCID: PMC2666598.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    45. Ochsner SA, Steffen DL, Hilsenbeck SG, Chen ES, Watkins C, McKenna NJ. GEMS (Gene Expression MetaSignatures), a Web resource for querying meta-analysis of expression microarray datasets: 17beta-estradiol in MCF-7 cells. Cancer Res. 2009 Jan 01; 69(1):23-6. PMID: 19117983; PMCID: PMC2782370.
      Citations: 39     Fields:    Translation:HumansCells
    46. Ochsner SA, Steffen DL, Stoeckert CJ, McKenna NJ. Much room for improvement in deposition rates of expression microarray datasets. Nat Methods. 2008 Dec; 5(12):991. PMID: 19034265; PMCID: PMC2975491.
      Citations: 21     Fields:    
    47. O'Malley BW, McKenna NJ. Coactivators and corepressors: what's in a name? Mol Endocrinol. 2008 Oct; 22(10):2213-4. PMID: 18701638; PMCID: PMC2582534.
      Citations: 17     Fields:    Translation:Humans
    48. Lanz RB, Jericevic Z, Zuercher WJ, Watkins C, Steffen DL, Margolis R, McKenna NJ. Nuclear Receptor Signaling Atlas ( hyperlinking the nuclear receptor signaling community. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D221-6. PMID: 16381851; PMCID: PMC1347392.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    49. McKenna NJ, O'Malley BW. Teaching resources. An interactive course in nuclear receptor signaling: concepts and models. Sci STKE. 2005 Aug 30; 2005(299):tr22. PMID: 16131668.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    50. Cheskis BJ, McKenna NJ, Wong CW, Wong J, Komm B, Lyttle CR, O'Malley BW. Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members. J Biol Chem. 2003 Apr 11; 278(15):13271-7. PMID: 12540843.
      Citations: 7     Fields:    Translation:AnimalsCells
    51. McKenna NJ, O'Malley BW. Minireview: nuclear receptor coactivators--an update. Endocrinology. 2002 Jul; 143(7):2461-5. PMID: 12072374.
      Citations: 91     Fields:    Translation:HumansAnimals
    52. McKenna NJ, O'Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell. 2002 Feb 22; 108(4):465-74. PMID: 11909518.
      Citations: 454     Fields:    Translation:HumansAnimalsCells
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