Loading...
Header Logo
Keywords
Last Name
Institution

YONGCHENG SONG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
DivisionPharmacology
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    R21AI090190     (SONG, YONGCHENG)Jun 1, 2010 - Nov 30, 2012
    NIH/NIAID
    Novel Metallo-beta-lactamase Inhibitors
    Role: Principal Investigator

    R21AI088123     (SONG, YONGCHENG)Jun 18, 2010 - Nov 30, 2012
    NIH/NIAID
    Novel inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR)
    Role: Principal Investigator

    R01NS080963     (SONG, YONGCHENG)Sep 30, 2012 - Aug 31, 2017
    NIH/NINDS
    Chemical Probes Targeting Gliomas with IDH Mutation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wu F, Song T, Yao Y, Song Y. Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1. PLoS One. 2019; 14(5):e0216203. PMID: 31048839.
      View in: PubMed
    2. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2019 02 22; 10(16):1603. PMID: 30899429.
      View in: PubMed
    3. Conley ZC, Carlson-Banning KM, Carter AG, de la Cova A, Song Y, Zechiedrich L. Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli. PLoS One. 2019; 14(1):e0210547. PMID: 30633761.
      View in: PubMed
    4. Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018; 8(8):2189-2201. PMID: 29721072.
      View in: PubMed
    5. Wu F, Cheng G, Yao Y, Kogiso M, Jiang H, Li XN, Song Y. Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer. Med Chem. 2018; 14(7):715-724. PMID: 29792149.
      View in: PubMed
    6. Zhou C, Wu F, Lu L, Wei L, Pai E, Yao Y, Song Y. Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1. PLoS One. 2017; 12(2):e0170301. PMID: 28158205.
      View in: PubMed
    7. Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 08 18; 128(7):971-81. PMID: 27335278.
      View in: PubMed
    8. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25. PMID: 27318434.
      View in: PubMed
    9. Song Y, Wu F, Wu J. Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. J Hematol Oncol. 2016 06 17; 9(1):49. PMID: 27316347.
      View in: PubMed
    10. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30. PMID: 27027445.
      View in: PubMed
    11. Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016 Mar 12; 9:24. PMID: 26970896.
      View in: PubMed
    12. Wu F, Zhou C, Yao Y, Wei L, Feng Z, Deng L, Song Y. 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2016 Jan 14; 59(1):253-263. PMID: 26652247.
      View in: PubMed
    13. Wu F, Jiang H, Zheng B, Kogiso M, Yao Y, Zhou C, Li XN, Song Y. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J Med Chem. 2015 Sep 10; 58(17):6899-6908. PMID: 26280302.
      View in: PubMed
    14. Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WC. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014 Nov 17; 5:5476. PMID: 25400145.
      View in: PubMed
    15. Zhang L, Deng L, Chen F, Yao Y, Wu B, Wei L, Mo Q, Song Y. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget. 2014 Nov 15; 5(21):10665-77. PMID: 25359765.
      View in: PubMed
    16. Liu Z, Yao Y, Kogiso M, Zheng B, Deng L, Qiu JJ, Dong S, Lv H, Gallo JM, Li XN, Song Y. Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. J Med Chem. 2014 Oct 23; 57(20):8307-18. PMID: 25271760.
      View in: PubMed
    17. Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BW. An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res. 2014 Jul; 24(7):809-19. PMID: 24874954.
      View in: PubMed
    18. Liu W, Deng L, Song Y, Redell M. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS One. 2014; 9(5):e98270. PMID: 24858818.
      View in: PubMed
    19. Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10). PMID: 24244836.
      View in: PubMed
    20. Anglin JL, Song Y. A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L. J Med Chem. 2013 Nov 27; 56(22):8972-83. PMID: 23879463.
      View in: PubMed
    21. Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One. 2013; 8(7):e69646. PMID: 23936064.
      View in: PubMed
    22. Zheng B, Yao Y, Liu Z, Deng L, Anglin JL, Jiang H, Prasad BV, Song Y. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13; 4(6):542-546. PMID: 23795241.
      View in: PubMed
    23. Deng L, Zhang L, Yao Y, Wang C, Redell MS, Dong S, Song Y. Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm. 2013 May 01; 4(5):822-826. PMID: 23795283.
      View in: PubMed
    24. Xue J, Diao J, Cai G, Deng L, Zheng B, Yao Y, Song Y. Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase. ACS Med Chem Lett. 2013 Feb 14; 4(2):278-282. PMID: 23795240.
      View in: PubMed
    25. Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92. PMID: 23365454.
      View in: PubMed
    26. Cai G, Deng L, Xue J, Moreno SN, Striepen B, Song Y. Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2158-61. PMID: 23428849.
      View in: PubMed
    27. Anglin JL, Deng L, Yao Y, Cai G, Liu Z, Jiang H, Cheng G, Chen P, Dong S, Song Y. Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem. 2012 Sep 27; 55(18):8066-74. PMID: 22924785.
      View in: PubMed
    28. Chen P, Horton LB, Mikulski RL, Deng L, Sundriyal S, Palzkill T, Song Y. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6229-32. PMID: 22921080.
      View in: PubMed
    29. Cai G, Deng L, Fryszczyn BG, Brown NG, Liu Z, Jiang H, Palzkill T, Song Y. Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Med Chem Lett. 2012 Jun 14; 3(6):496-500. PMID: 23050057.
      View in: PubMed
    30. Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y. Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. J Am Chem Soc. 2011 Oct 26; 133(42):16746-9. PMID: 21936531.
      View in: PubMed
    31. Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y. Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies. J Med Chem. 2011 Jul 14; 54(13):4721-34. PMID: 21561155.
      View in: PubMed
    32. Deng L, Endo K, Kato M, Cheng G, Yajima S, Song Y. Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ACS Med Chem Lett. 2011 Feb 10; 2(2):165-170. PMID: 21379374.
      View in: PubMed
    33. Deng L, Sundriyal S, Rubio V, Shi ZZ, Song Y. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem. 2009 Nov 12; 52(21):6539-42. PMID: 19888756.
      View in: PubMed
    34. Feng Q, He B, Jung SY, Song Y, Qin J, Tsai SY, Tsai MJ, O'Malley BW. Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009 Dec 25; 284(52):36167-74. PMID: 19843527.
      View in: PubMed
    SONG's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description