"Proprotein Convertase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
| Descriptor ID |
D045706
|
| MeSH Number(s) |
D08.811.277.656.300.760.646 D08.811.277.656.837.562 D08.811.277.656.959.350.646
|
| Concept/Terms |
Proprotein Convertase 2- Proprotein Convertase 2
- PC2 Prohormone Convertase
- PC2 Protein
- Endopeptidase PC2
- PC2, Endopeptidase
- Prohormone Convertase 2
- Convertase 2, Prohormone
- Prohormone Convertase PC2
- Convertase PC2, Prohormone
- Proinsulin Convertase 2
- Convertase 2, Proinsulin
- Prohormone Convertase, PC2
- Convertase, PC2 Prohormone
- PC2 Endoprotease
- Endoprotease, PC2
- Neuroendocrine Convertase PC2
- Convertase PC2, Neuroendocrine
|
Below are MeSH descriptors whose meaning is more general than "Proprotein Convertase 2".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertase 2".
This graph shows the total number of publications written about "Proprotein Convertase 2" by people in this website by year, and whether "Proprotein Convertase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proprotein Convertase 2" by people in Profiles.
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The Nutrient and Energy Sensor Sirt1 Regulates the Hypothalamic-Pituitary-Adrenal (HPA) Axis by Altering the Production of the Prohormone Convertase 2 (PC2) Essential in the Maturation of Corticotropin-releasing Hormone (CRH) from Its Prohormone in Male Rats. J Biol Chem. 2016 Mar 11; 291(11):5844-5859.
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A genome-wide association meta-analysis of preschool internalizing problems. J Am Acad Child Adolesc Psychiatry. 2014 Jun; 53(6):667-676.e7.
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Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. J Biol Chem. 2013 Jun 14; 288(24):17675-88.
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Mechanisms by which the orexigen NPY regulates anorexigenic a-MSH and TRH. Am J Physiol Endocrinol Metab. 2013 Mar 15; 304(6):E640-50.
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Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice. Peptides. 2012 May; 35(1):42-8.
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Proprotein processing and pancreatic islet function. Adv Exp Med Biol. 2004; 552:39-65.
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Proinsulin processing in the diabetic Goto-Kakizaki rat. J Endocrinol. 2002 Dec; 175(3):637-47.
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Increased expression of prohormone convertase-2 in the irradiated rat brain. FASEB J. 1998 Dec; 12(15):1725-30.