TNF-Related Apoptosis-Inducing Ligand
"TNF-Related Apoptosis-Inducing Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
| Descriptor ID |
D053221
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| MeSH Number(s) |
D12.644.276.374.750.625 D12.776.467.374.750.625 D23.529.374.750.625
|
| Concept/Terms |
TNF-Related Apoptosis-Inducing Ligand- TNF-Related Apoptosis-Inducing Ligand
- Apoptosis-Inducing Ligand, TNF-Related
- TNF Related Apoptosis Inducing Ligand
- Apo-2 Ligand
- Apo 2 Ligand
- Tumor Necrosis Factor Ligand Superfamily Member 10
- Apo-2L Protein
- Apo 2L Protein
- TNF Superfamily, Member 10
- CD253 Antigen
- Antigen, CD253
- TRAIL Protein
|
Below are MeSH descriptors whose meaning is more general than "TNF-Related Apoptosis-Inducing Ligand".
Below are MeSH descriptors whose meaning is more specific than "TNF-Related Apoptosis-Inducing Ligand".
This graph shows the total number of publications written about "TNF-Related Apoptosis-Inducing Ligand" by people in this website by year, and whether "TNF-Related Apoptosis-Inducing Ligand" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 3 | 3 |
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Below are the most recent publications written about "TNF-Related Apoptosis-Inducing Ligand" by people in Profiles.
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A comparison of host response strategies to distinguish bacterial and viral infection. PLoS One. 2021; 16(12):e0261385.
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Enhancing the Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Signaling and Arginine Deprivation in Melanoma. Int J Mol Sci. 2021 Jul 16; 22(14).
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ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms. Mol Cancer Ther. 2017 07; 16(7):1290-1298.
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Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 11 01; 23(11):1886-1896.
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c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer. Clin Cancer Res. 2017 May 15; 23(10):2542-2555.
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Cytokine Panel for Response to Intravesical Therapy (CyPRIT): Nomogram of Changes in Urinary Cytokine Levels Predicts Patient Response to Bacillus Calmette-Gu?rin. Eur Urol. 2016 02; 69(2):197-200.
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5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis. Mol Oncol. 2015 Nov; 9(9):1815-24.
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Dulanermin with rituximab in patients with relapsed indolent B-cell lymphoma: an open-label phase 1b/2 randomised study. Lancet Haematol. 2015 Apr; 2(4):e166-74.
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Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS One. 2015; 10(3):e0117994.
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Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks. Nat Commun. 2014 Dec 15; 5:5811.