Nuclear Receptor Subfamily 6, Group A, Member 1
"Nuclear Receptor Subfamily 6, Group A, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor expressed mainly in the GERM CELLS of GONADS. It functions as a transcription factor that binds to a direct repeat of the sequence AGGTCA and may play a role in the regulation of EMBRYOGENESIS and germ cell differentiation.
| Descriptor ID |
D057136
|
| MeSH Number(s) |
D12.776.260.643.572 D12.776.826.209.572
|
| Concept/Terms |
Nuclear Receptor Subfamily 6, Group A, Member 1- Nuclear Receptor Subfamily 6, Group A, Member 1
- Retinoid Receptor-Related Testis-Associated Receptor
- Retinoid Receptor Related Testis Associated Receptor
- Nuclear Receptor NR6A1
- Retinoid Receptor Related Testis Specific Receptor
- Germ Cell Nuclear Factor
- Neuronal Cell Nuclear Factor
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 6, Group A, Member 1".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 6, Group A, Member 1".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 6, Group A, Member 1" by people in this website by year, and whether "Nuclear Receptor Subfamily 6, Group A, Member 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nuclear Receptor Subfamily 6, Group A, Member 1" by people in Profiles.
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Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells. J Biol Chem. 2016 Apr 15; 291(16):8644-52.
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Germ cell nuclear factor regulates gametogenesis in developing gonads. PLoS One. 2014; 9(8):e103985.
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GCNF-dependent activation of cyclin D1 expression via repression of Mir302a during ESC differentiation. Stem Cells. 2014 Jun; 32(6):1527-37.
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Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells. Stem Cells. 2013 Dec; 31(12):2659-66.
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Revisiting the role of GCNF in embryonic development. Semin Cell Dev Biol. 2013 Dec; 24(10-12):679-86.
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Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4. Stem Cells. 2011 Jul; 29(7):1041-51.
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Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. J Neurosci. 2009 Feb 18; 29(7):2113-24.
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Extra-germ cell expression of mouse nuclear receptor subfamily 6, group A, member 1 (NR6A1). Biol Reprod. 2009 May; 80(5):905-12.
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Candidate genes for premature ovarian failure. Curr Med Chem. 2007; 14(3):353-7.
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Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer. Dev Biol. 2006 May 01; 293(1):13-24.