"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Descriptor ID |
D004249
|
MeSH Number(s) |
G05.200
|
Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
|
Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 4 | 4 |
1996 | 3 | 4 | 7 |
1997 | 0 | 4 | 4 |
1998 | 3 | 4 | 7 |
1999 | 4 | 5 | 9 |
2000 | 1 | 5 | 6 |
2001 | 3 | 3 | 6 |
2002 | 6 | 6 | 12 |
2003 | 7 | 10 | 17 |
2004 | 7 | 11 | 18 |
2005 | 9 | 6 | 15 |
2006 | 5 | 6 | 11 |
2007 | 5 | 5 | 10 |
2008 | 3 | 7 | 10 |
2009 | 4 | 6 | 10 |
2010 | 5 | 15 | 20 |
2011 | 4 | 11 | 15 |
2012 | 5 | 6 | 11 |
2013 | 4 | 3 | 7 |
2014 | 6 | 9 | 15 |
2015 | 7 | 13 | 20 |
2016 | 1 | 6 | 7 |
2017 | 11 | 5 | 16 |
2018 | 8 | 10 | 18 |
2019 | 6 | 7 | 13 |
2020 | 3 | 9 | 12 |
2021 | 6 | 9 | 15 |
2022 | 1 | 4 | 5 |
2023 | 0 | 9 | 9 |
2024 | 5 | 3 | 8 |
2025 | 3 | 1 | 4 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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DNA-PK Inhibition Shows Differential Radiosensitization in Orthotopic GBM PDX Models Based on DDR Pathway Deficits. Mol Cancer Ther. 2025 Jun 04; 24(6):859-869.
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G-quadruplex stabilizer CX-5461 effectively combines with radiotherapy to target a-thalassemia/mental retardation X-linked-deficient malignant glioma. Neuro Oncol. 2025 May 15; 27(4):932-947.
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ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders. J Clin Invest. 2025 Apr 15; 135(8).
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DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia. Blood. 2025 Mar 13; 145(11):1182-1194.
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Endogenous DNA damage at sites of terminated transcripts. Nature. 2025 Apr; 640(8057):240-248.
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Transcriptomic markers of biological aging in breast cancer survivors: a longitudinal study. J Natl Cancer Inst. 2025 Feb 01; 117(2):312-321.
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Placentas From SARS-CoV-2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage. Am J Reprod Immunol. 2025 Jan; 93(1):e70034.
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PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy. Sci Rep. 2024 12 28; 14(1):30897.
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UBA1 inhibition sensitizes cancer cells to PARP inhibitors. Cell Rep Med. 2024 Dec 17; 5(12):101834.
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Clues to transcription/replication collision-induced DNA damage: it was RNAP, in the chromosome, with the fork. FEBS Lett. 2025 Jan; 599(2):209-243.