 DNA Damage
"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
| Descriptor ID |
D004249
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| MeSH Number(s) |
G05.200
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| Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
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Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 5 | 4 | 9 | | 1990 | 2 | 4 | 6 | | 1991 | 4 | 4 | 8 | | 1992 | 3 | 4 | 7 | | 1993 | 6 | 8 | 14 | | 1994 | 4 | 14 | 18 | | 1995 | 7 | 10 | 17 | | 1996 | 8 | 9 | 17 | | 1997 | 6 | 12 | 18 | | 1998 | 7 | 14 | 21 | | 1999 | 21 | 11 | 32 | | 2000 | 14 | 14 | 28 | | 2001 | 22 | 18 | 40 | | 2002 | 22 | 27 | 49 | | 2003 | 29 | 29 | 58 | | 2004 | 33 | 28 | 61 | | 2005 | 30 | 28 | 58 | | 2006 | 28 | 28 | 56 | | 2007 | 23 | 23 | 46 | | 2008 | 25 | 20 | 45 | | 2009 | 22 | 31 | 53 | | 2010 | 19 | 46 | 65 | | 2011 | 19 | 35 | 54 | | 2012 | 14 | 32 | 46 | | 2013 | 17 | 35 | 52 | | 2014 | 18 | 28 | 46 | | 2015 | 19 | 28 | 47 | | 2016 | 15 | 23 | 38 | | 2017 | 23 | 29 | 52 | | 2018 | 12 | 19 | 31 | | 2019 | 1 | 3 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Pribis JP, García-Villada L, Zhai Y, Lewin-Epstein O, Wang AZ, Liu J, Xia J, Mei Q, Fitzgerald DM, Bos J, Austin RH, Herman C, Bates D, Hadany L, Hastings PJ, Rosenberg SM. Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response. Mol Cell. 2019 05 16; 74(4):785-800.e7.
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Wang Y, Yang J, Wild AT, Wu WH, Shah R, Danussi C, Riggins GJ, Kannan K, Sulman EP, Chan TA, Huse JT. G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma. Nat Commun. 2019 02 26; 10(1):943.
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Pilié PG, Tang C, Mills GB, Yap TA. State-of-the-art strategies for targeting the DNA damage response in cancer. Nat Rev Clin Oncol. 2019 02; 16(2):81-104.
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Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.
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Vogel S, Ebel K, Heck C, Schürmann RM, Milosavljevic AR, Giuliani A, Bald I. Vacuum-UV induced DNA strand breaks - influence of the radiosensitizers 5-bromouracil and 8-bromoadenine. Phys Chem Chem Phys. 2019 Jan 23; 21(4):1972-1979.
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McConkey DJ, Lerner SP. SIU-ICUD consultation on bladder cancer: basic science. World J Urol. 2019 Jan; 37(1):15-29.
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Pearson SJ, Roy Sarkar T, McQueen CM, Elswood J, Schmitt EE, Wall SW, Scribner KC, Wyatt G, Barhoumi R, Behbod F, Rijnkels M, Porter WW. ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene. 2019 04; 38(14):2611-2626.
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Wang C, Wang G, Feng X, Shepherd P, Zhang J, Tang M, Chen Z, Srivastava M, McLaughlin ME, Navone NM, Hart GT, Chen J. Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene. 2019 04; 38(14):2451-2463.
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Zheng S, Li D, Lu Z, Liu G, Wang M, Xing P, Wang M, Dong Y, Wang X, Li J, Zhang S, Peng H, Ira G, Li G, Chen X. Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks. Nucleic Acids Res. 2018 11 30; 46(21):11326-11339.
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Carroll JE, Van Dyk K, Bower JE, Scuric Z, Petersen L, Schiestl R, Irwin MR, Ganz PA. Cognitive performance in survivors of breast cancer and markers of biological aging. Cancer. 2019 01 15; 125(2):298-306.
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