"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
| Descriptor ID |
D001905
|
| MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
|
| Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
|
Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 2 | 0 | 2 |
| 1996 | 1 | 1 | 2 |
| 1997 | 3 | 0 | 3 |
| 1998 | 3 | 2 | 5 |
| 1999 | 1 | 2 | 3 |
| 2000 | 1 | 1 | 2 |
| 2001 | 4 | 2 | 6 |
| 2002 | 3 | 0 | 3 |
| 2003 | 1 | 1 | 2 |
| 2004 | 5 | 0 | 5 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 2 | 4 |
| 2007 | 3 | 1 | 4 |
| 2008 | 4 | 0 | 4 |
| 2009 | 4 | 1 | 5 |
| 2010 | 2 | 0 | 2 |
| 2011 | 8 | 0 | 8 |
| 2012 | 1 | 2 | 3 |
| 2013 | 5 | 2 | 7 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 1 | 3 |
| 2016 | 2 | 2 | 4 |
| 2017 | 4 | 1 | 5 |
| 2018 | 4 | 0 | 4 |
| 2019 | 3 | 0 | 3 |
| 2020 | 2 | 2 | 4 |
| 2021 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
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Botulinum toxin treatment in parkinsonism. J Neurol Sci. 2024 01 15; 456:122810.
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Botulinum Neurotoxin Injections in Children with Self-Injurious Behaviors. Toxins (Basel). 2023 03 23; 15(4).
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Combined Immunodeficiency Caused by a Novel De Novo Gain-of-Function RAC2 Mutation. J Clin Immunol. 2022 08; 42(6):1280-1292.
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Exploring the role of botulinum toxin in critical care. Expert Rev Neurother. 2021 08; 21(8):881-894.
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Botulinum Neurotoxin Injections in Childhood Opisthotonus. Toxins (Basel). 2021 02 12; 13(2).
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Botulinum Toxin in Movement Disorders: An Update. Toxins (Basel). 2021 Jan 08; 13(1).
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Spasticity Management in Persons with Disorders of Consciousness. PM R. 2021 07; 13(7):657-665.
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Polytetrafluoroethylene frontalis suspension in blepharospasm with eyelid apraxia: an effective and well-tolerated adjunct to botulinum toxin therapy. Orbit. 2021 Feb; 40(1):39-43.
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Treatment of Tardive Dyskinesia. Neurol Clin. 2020 05; 38(2):379-396.
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Medical Updates in Management of Hypertonia. Phys Med Rehabil Clin N Am. 2020 02; 31(1):57-68.