Pregnancy-Associated Plasma Protein-A
"Pregnancy-Associated Plasma Protein-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
| Descriptor ID |
D011266
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| MeSH Number(s) |
D08.811.277.656.300.480.632 D08.811.277.656.675.374.632 D12.776.780.700
|
| Concept/Terms |
Pregnancy-Associated Plasma Protein-A- Pregnancy-Associated Plasma Protein-A
- Pregnancy Associated Plasma Protein A
- IGFBP-4 Protease
- IGFBP 4 Protease
- Protease, IGFBP-4
- IGFBP-4-Specific Proteinase
- Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
- Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease
- PAPP-A
- PAPP-alpha
- PAPP alpha
- Pregnancy Associated alpha Plasma Protein
- Pregnancy-Associated alpha-Plasma Protein
- IGFBP-4 Metalloproteinase
- IGFBP 4 Metalloproteinase
- Metalloproteinase, IGFBP-4
- Insulin-Like-Growth Factor Binding Protein-4 Protease
- Insulin Like Growth Factor Binding Protein 4 Protease
|
Below are MeSH descriptors whose meaning is more general than "Pregnancy-Associated Plasma Protein-A".
Below are MeSH descriptors whose meaning is more specific than "Pregnancy-Associated Plasma Protein-A".
This graph shows the total number of publications written about "Pregnancy-Associated Plasma Protein-A" by people in this website by year, and whether "Pregnancy-Associated Plasma Protein-A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pregnancy-Associated Plasma Protein-A" by people in Profiles.
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Pregnancy-associated plasma protein-A (PAPP-A) is a key component of an interactive cellular mechanism promoting pulmonary fibrosis. J Cell Physiol. 2022 04; 237(4):2220-2229.
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Microarray analysis: First-trimester maternal serum free ?-hCG and the risk of significant copy number variants. Prenat Diagn. 2018 11; 38(12):971-978.
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Rare and low-frequency coding variants alter human adult height. Nature. 2017 02 09; 542(7640):186-190.
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Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer. EMBO Mol Med. 2016 04 01; 8(4):388-406.
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Prediction of patient-specific risk for fetal loss using maternal characteristics and first- and second-trimester maternal serum Down syndrome markers. Am J Obstet Gynecol. 2008 Sep; 199(3):290.e1-6.
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Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department. Int J Cardiol. 2007 May 02; 117(3):365-9.
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Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. Eur Heart J. 2006 Jul; 27(14):1678-84.
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Evidence-based obstetric ethics and informed decision-making by pregnant women about invasive diagnosis after first-trimester assessment of risk for trisomy 21. Am J Obstet Gynecol. 2005 Aug; 193(2):322-6.