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BELLEN, HUGO
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overview Investigator, Howard Hughes Medical Institute, Baylor College of Medicine Professor, Departments of Molecular and Human Genetics and Neuroscience Director, Program in Developmental Biology I am interested in (1) providing a better fundamental understanding of the biology that governs the proper function and maintenance of neurons in aging adults (2) developing tools that can be applied to most genes to control transcript and protein levels in adult neurons to assess which proteins are required for neuronal survival and proper function (3) creating genome wide libraries to manipulate most genes in vivo. My lab uses the fruit fly Drosophila melanogaster as a model system because most biological processes are evolutionarily conserved and studies in fruit flies provide many important clues about the aging process in animals and human diseases.
One or more keywords matched the following items that are connected to BELLEN, HUGO
Item TypeName
Academic Article Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development.
Academic Article Senseless acts as a binary switch during sensory organ precursor selection.
Academic Article Mapping and identification of essential gene functions on the X chromosome of Drosophila.
Academic Article Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner.
Academic Article Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.
Academic Article Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation.
Academic Article Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster.
Academic Article Emerging technologies for gene manipulation in Drosophila melanogaster.
Academic Article Internalization is required for proper Wingless signaling in Drosophila melanogaster.
Academic Article Genetic manipulation of genes and cells in the nervous system of the fruit fly.
Academic Article Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).
Academic Article P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.
Academic Article The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.
Academic Article Activity-independent prespecification of synaptic partners in the visual map of Drosophila.
Academic Article The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
Academic Article The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors.
Academic Article A molecularly defined duplication set for the X chromosome of Drosophila melanogaster.
Academic Article The Drosophila gene disruption project: progress using transposons with distinctive site specificities.
Academic Article A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene.
Academic Article MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes.
Academic Article The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit.
Academic Article Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
Academic Article dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions.
Academic Article Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.
Academic Article Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.
Academic Article The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes.
Academic Article Gfi/Pag-3/senseless zinc finger proteins: a unifying theme?
Academic Article Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin.
Academic Article Transgenesis upgrades for Drosophila melanogaster.
Academic Article Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
Academic Article Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.
Concept Transgenes
Concept Genes, Insect
Concept Genes, Reporter
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Profiling
Concept Gene Regulatory Networks
Concept Multigene Family
Concept Epistasis, Genetic
Concept Gene Expression
Concept Open Reading Frames
Concept Genes
Concept Amino Acid Sequence
Concept Genes, Dominant
Concept Sequence Homology
Concept Trinucleotide Repeat Expansion
Concept Gene Knock-In Techniques
Concept Gene Order
Concept Genome, Human
Concept Gene Targeting
Concept Polymorphism, Single Nucleotide
Concept Genome, Insect
Concept Genes, Essential
Concept Gene Library
Concept Sequence Homology, Amino Acid
Concept Sequence Homology, Nucleic Acid
Concept Artificial Gene Fusion
Concept Genome
Concept Gene Deletion
Concept Gene Silencing
Concept Gene Knockout Techniques
Concept Base Sequence
Concept Alleles
Concept Genes, Recessive
Concept Gene Knockdown Techniques
Concept Genes, Homeobox
Concept Gene Transfer Techniques
Concept Molecular Sequence Data
Concept Gene Expression Regulation, Developmental
Concept Conserved Sequence
Concept Repetitive Sequences, Nucleic Acid
Concept Gene Expression Regulation
Concept Consensus Sequence
Concept Gene Dosage
Academic Article Protein phosphatase 1? limits ring canal constriction during Drosophila germline cyst formation.
Academic Article miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.
Academic Article Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster.
Academic Article Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11.
Academic Article Introduction to Notch signaling.
Academic Article Large-scale identification of chemically induced mutations in Drosophila melanogaster.
Academic Article Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production.
Academic Article Huntingtin functions as a scaffold for selective macroautophagy.
Academic Article A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
Academic Article A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila.
Academic Article A genetic toolkit for tagging intronic MiMIC containing genes.
Academic Article The retromer complex in development and disease.
Academic Article BIOSAFETY. Safeguarding gene drive experiments in the laboratory.
Academic Article FlyVar: a database for genetic variation in Drosophila melanogaster.
Academic Article Morgan's legacy: fruit flies and the functional annotation of conserved genes.
Academic Article Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.
Academic Article Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
Academic Article Mutations in neuromusculin, a gene encoding a cell adhesion molecule, cause nervous system defects.
Academic Article Primordium specific requirement of the homeotic gene fork head in the developing gut of the Drosophila embryo.
Academic Article A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells.
Academic Article A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
Academic Article A gene-specific T2A-GAL4 library for Drosophila.
Academic Article Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.
Academic Article Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila.
Academic Article Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to a-Synuclein Gain.
Academic Article The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Academic Article Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.
Academic Article An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila.
Academic Article Interactions between the Ig-Superfamily Proteins DIP-a and Dpr6/10 Regulate Assembly of Neural Circuits.
Grant Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
Grant A Comprehensive Resource for Manipulating the Drosophila Genome
Grant Molecularly defined duplications for the X-chromosome and large autosomal genes
Grant A Human cDNA Library for Functional Gene Replacement in Drosophila
Grant A multi-species approach to find regulators of deafness genes
Grant Using CRISPR technology to study the function of paralogous genes
Grant Center for functional analysis of human UDN gene homologs in Drosophila and zebrafish
Academic Article Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
Concept Gene Editing
Concept Transcriptome
Concept Exome
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Academic Article cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Academic Article Using MARRVEL v1.2 for Bioinformatics Analysis of Human Genes and Variant Pathogenicity.
Academic Article An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms.
Academic Article Use of the CRISPR-Cas9 System in Drosophila Cultured Cells to Introduce Fluorescent Tags into Endogenous Genes.
Academic Article The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation.
Academic Article Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains.
Academic Article BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
Academic Article Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features.
Grant A Comprehensive Resource for Manipulating the Drosophila Genome
Grant Genomic medicine and gene function implementation for an underserved population
Academic Article TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
Grant IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASE
Academic Article Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
Academic Article The microRNA processor DROSHA is a candidate gene for a severe progressive neurological disorder.
Academic Article Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons.
Academic Article An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination.
Academic Article The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival.
Academic Article Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution.
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  • Genes