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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.
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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.
XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature. 2016 Oct 06; 538(7623):114-117.
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subject areas
Active Transport, Cell Nucleus
Adaptor Proteins, Signal Transducing
Animals
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Cell Nucleus
Cell Proliferation
Cell Survival
DNA-Binding Proteins
Female
Follistatin-Related Proteins
Genes, Lethal
Humans
Karyopherins
Lung Neoplasms
Mice
Mutation
NF-kappa B
NF-KappaB Inhibitor alpha
Nuclear Proteins
Phosphoproteins
Porphyrins
Proto-Oncogene Proteins p21(ras)
Receptors, Cytoplasmic and Nuclear
RNA Interference
RNA, Small Interfering
Signal Transduction
Transcription Factors
Xenograft Model Antitumor Assays
authors with profiles
IGNACIO IVAN WISTUBA