Metabolic Detoxication, Phase II
"Metabolic Detoxication, Phase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
| Descriptor ID |
D050217
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| MeSH Number(s) |
G03.171.450.750 G03.787.225.450.750 G07.690.725.225.450.750
|
| Concept/Terms |
Metabolic Detoxication, Phase II- Metabolic Detoxication, Phase II
- Metabolic Detoxication, Conjugative
- Conjugative Metabolic Detoxication
- Conjugative Metabolic Detoxications
- Detoxication, Conjugative Metabolic
- Detoxications, Conjugative Metabolic
- Metabolic Detoxications, Conjugative
- Phase II Detoxification
- Detoxification, Phase II
- Detoxifications, Phase II
- Phase II Detoxifications
- Metabolic Detoxification, Phase II
|
Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase II".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase II".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase II" by people in this website by year, and whether "Metabolic Detoxication, Phase II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metabolic Detoxication, Phase II" by people in Profiles.
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Targeted metabolomics analysis of maternal-placental-fetal metabolism in pregnant swine reveals links in fetal bile acid homeostasis and sulfation capacity. Am J Physiol Gastrointest Liver Physiol. 2019 07 01; 317(1):G8-G16.
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Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Pharm Res. 2016 Mar; 33(3):590-602.
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Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 01; 97(1):111-21.
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Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein. Drug Metab Dispos. 2012 Oct; 40(10):1883-93.
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An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. Pediatr Blood Cancer. 2012 Oct; 59(4):605-10.
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Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis. Curr Drug Metab. 2011 Nov; 12(9):900-16.
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Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One. 2011; 6(10):e26589.
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Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81.
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Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Toxicol Sci. 2008 Apr; 102(2):337-44.
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Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes. Mutat Res. 2007 Mar 05; 627(2):146-57.