"Inactivation, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
| Descriptor ID |
D008658
|
| MeSH Number(s) |
G03.171.450 G03.787.225.450 G07.690.725.225.450
|
| Concept/Terms |
Metabolic Detoxication, Drug- Metabolic Detoxication, Drug
- Detoxication, Drug Metabolic
- Drug Metabolic Detoxication
- Drug Detoxication, Metabolic
- Detoxication, Metabolic Drug
- Metabolic Drug Detoxication
- Metabolic Detoxification, Drug
- Detoxification, Drug Metabolic
- Drug Metabolic Detoxification
- Detoxification, Drug, Metabolic
- Detoxication, Drug, Metabolic
|
Below are MeSH descriptors whose meaning is more general than "Inactivation, Metabolic".
Below are MeSH descriptors whose meaning is more specific than "Inactivation, Metabolic".
This graph shows the total number of publications written about "Inactivation, Metabolic" by people in this website by year, and whether "Inactivation, Metabolic" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Inactivation, Metabolic" by people in Profiles.
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DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis. 2019 11 25; 40(11):1332-1340.
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Transcriptome Profiling of Placenta through Pregnancy Reveals Dysregulation of Bile Acids Transport and Detoxification Function. Int J Mol Sci. 2019 Aug 22; 20(17).
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P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metab Dispos. 2018 11; 46(11):1734-1744.
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Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro. Drug Metab Dispos. 2018 04; 46(4):397-404.
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Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice. Blood. 2016 12 15; 128(24):2774-2784.
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Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Mol Nutr Food Res. 2016 09; 60(9):1967-83.
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Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients. Mol Cancer Ther. 2015 Dec; 14(12):2874-86.
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Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014 Apr 17; 508(7496):406-10.
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Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81.
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Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. Clin Cancer Res. 2010 Dec 15; 16(24):6169-76.