Metabolic Detoxication, Phase I
"Metabolic Detoxication, Phase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
| Descriptor ID |
D050216
|
| MeSH Number(s) |
G03.171.450.500 G03.787.225.450.500 G07.690.725.225.450.500
|
| Concept/Terms |
Metabolic Detoxication, Phase I- Metabolic Detoxication, Phase I
- Metabolic Detoxication, Oxidative
- Detoxication, Oxidative Metabolic
- Detoxications, Oxidative Metabolic
- Metabolic Detoxications, Oxidative
- Oxidative Metabolic Detoxication
- Oxidative Metabolic Detoxications
- Phase I Detoxification
- Detoxification, Phase I
- Detoxifications, Phase I
- Metabolic Detoxification, Phase I
|
Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase I".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase I".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase I" by people in this website by year, and whether "Metabolic Detoxication, Phase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metabolic Detoxication, Phase I" by people in Profiles.
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Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 01; 97(1):111-21.
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An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. Pediatr Blood Cancer. 2012 Oct; 59(4):605-10.
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Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. PLoS One. 2011; 6(10):e26589.
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Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81.