BH3 Interacting Domain Death Agonist Protein
"BH3 Interacting Domain Death Agonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.
| Descriptor ID |
D051023
|
| MeSH Number(s) |
D12.644.360.075.718.968 D12.776.476.075.718.937
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "BH3 Interacting Domain Death Agonist Protein".
Below are MeSH descriptors whose meaning is more specific than "BH3 Interacting Domain Death Agonist Protein".
This graph shows the total number of publications written about "BH3 Interacting Domain Death Agonist Protein" by people in this website by year, and whether "BH3 Interacting Domain Death Agonist Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "BH3 Interacting Domain Death Agonist Protein" by people in Profiles.
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A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell. 2011 Nov 18; 44(4):517-31.
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Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma. Br J Haematol. 2011 Mar; 152(5):579-92.
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The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy. Autophagy. 2010 Oct; 6(7):976-8.
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VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria. EMBO Rep. 2009 Dec; 10(12):1341-7.
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Redox stress and the contributions of BH3-only proteins to infarction. Antioxid Redox Signal. 2006 Sep-Oct; 8(9-10):1667-76.
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Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell. 2006 May; 17(5):2150-7.
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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005 Feb 18; 17(4):525-35.
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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004 Feb 13; 303(5660):1010-4.
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Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1). Cell Death Differ. 2003 Dec; 10(12):1329-35.
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VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science. 2003 Jul 25; 301(5632):513-7.