BH3 Interacting Domain Death Agonist Protein
"BH3 Interacting Domain Death Agonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.
| Descriptor ID |
D051023
|
| MeSH Number(s) |
D12.644.360.075.718.968 D12.776.476.075.718.937
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "BH3 Interacting Domain Death Agonist Protein".
Below are MeSH descriptors whose meaning is more specific than "BH3 Interacting Domain Death Agonist Protein".
This graph shows the total number of publications written about "BH3 Interacting Domain Death Agonist Protein" by people in this website by year, and whether "BH3 Interacting Domain Death Agonist Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "BH3 Interacting Domain Death Agonist Protein" by people in Profiles.
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Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma. Br J Haematol. 2011 Mar; 152(5):579-92.
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The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy. Autophagy. 2010 Oct; 6(7):976-8.
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VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science. 2003 Jul 25; 301(5632):513-7.
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The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. 2001 Nov 22; 20(53):7779-86.
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Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med. 2001 Nov 05; 194(9):1325-37.
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A role for mitochondrial Bak in apoptotic response to anticancer drugs. J Biol Chem. 2001 Sep 07; 276(36):34307-17.