bcl-2-Associated X Protein
"bcl-2-Associated X Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
| Descriptor ID |
D051028
|
| MeSH Number(s) |
D12.644.360.075.718.400 D12.776.476.075.718.400
|
| Concept/Terms |
bcl-2-Associated X Protein- bcl-2-Associated X Protein
- Protein, bcl-2-Associated X
- X Protein, bcl-2-Associated
- bcl 2 Associated X Protein
- Bax Apoptosis Regulator Protein
- Bax Protein
- bcl2-Associated X Protein
- bcl2 Associated X Protein
|
Below are MeSH descriptors whose meaning is more general than "bcl-2-Associated X Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2-Associated X Protein".
This graph shows the total number of publications written about "bcl-2-Associated X Protein" by people in this website by year, and whether "bcl-2-Associated X Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 5 | 5 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 4 | 6 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 4 | 5 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 3 | 4 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 3 | 4 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "bcl-2-Associated X Protein" by people in Profiles.
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Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling. Mol Cancer Ther. 2021 08; 20(8):1469-1480.
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The role of FAS, FAS-L, BAX, and BCL-2 gene polymorphisms in determining susceptibility to unexplained recurrent pregnancy loss. J Assist Reprod Genet. 2019 May; 36(5):995-1002.
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Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. Elife. 2017 11 17; 6.
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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20; 24(4):493-506.e5.
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The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation. Sci Rep. 2016 09 13; 6:32994.
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[6]-Shogaol, a Novel Chemopreventor in 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis. Phytother Res. 2016 Apr; 30(4):646-53.
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Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function. Int J Biochem Cell Biol. 2016 Jan; 70:105-17.
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Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS One. 2015; 10(6):e0130520.
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Astrocyte-conditioned medium attenuates glutamate-induced apoptotic cell death in primary cultured spinal cord neurons of rats. Neurol Res. 2015 Sep; 37(9):803-8.
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Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circ Res. 2015 May 22; 116(11):1800-9.