bcl-2 Homologous Antagonist-Killer Protein
"bcl-2 Homologous Antagonist-Killer Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
| Descriptor ID |
D050998
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| MeSH Number(s) |
D12.644.360.075.718.750 D12.776.476.075.718.425
|
| Concept/Terms |
bcl-2 Homologous Antagonist-Killer Protein- bcl-2 Homologous Antagonist-Killer Protein
- bcl 2 Homologous Antagonist Killer Protein
- bcl2 Homologous Antagonist-Killer Protein
- bcl2 Homologous Antagonist Killer Protein
- Bak Protein
|
Below are MeSH descriptors whose meaning is more general than "bcl-2 Homologous Antagonist-Killer Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2 Homologous Antagonist-Killer Protein".
This graph shows the total number of publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in this website by year, and whether "bcl-2 Homologous Antagonist-Killer Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 1 | 2 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 2 | 3 |
| 2010 | 1 | 4 | 5 |
| 2011 | 0 | 4 | 4 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in Profiles.
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BAK contributes critically to necrosis and infarct generation during reperfused myocardial infarction. J Mol Cell Cardiol. 2023 11; 184:1-12.
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Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury. Sci Rep. 2018 02 27; 8(1):3689.
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Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. Elife. 2017 11 17; 6.
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MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway. Pigment Cell Melanoma Res. 2017 05; 30(3):328-338.
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Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017 07; 56(7):548-558.
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Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PLoS One. 2015; 10(6):e0130520.
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Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circ Res. 2015 May 22; 116(11):1800-9.
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Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells. PLoS One. 2014; 9(3):e89064.
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BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS One. 2014; 9(1):e84388.
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Apoptosis and in situ and invasive squamous cell carcinoma in sun-exposed sites. Am J Dermatopathol. 2013 Dec; 35(8):797-803.