bcl-2 Homologous Antagonist-Killer Protein
"bcl-2 Homologous Antagonist-Killer Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
| Descriptor ID |
D050998
|
| MeSH Number(s) |
D12.644.360.075.718.750 D12.776.476.075.718.425
|
| Concept/Terms |
bcl-2 Homologous Antagonist-Killer Protein- bcl-2 Homologous Antagonist-Killer Protein
- bcl 2 Homologous Antagonist Killer Protein
- bcl2 Homologous Antagonist-Killer Protein
- bcl2 Homologous Antagonist Killer Protein
- Bak Protein
|
Below are MeSH descriptors whose meaning is more general than "bcl-2 Homologous Antagonist-Killer Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2 Homologous Antagonist-Killer Protein".
This graph shows the total number of publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in this website by year, and whether "bcl-2 Homologous Antagonist-Killer Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in Profiles.
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Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol. 2011 Dec 01; 187(11):5684-92.
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Blockade of interleukin-6 signalling with siltuximab enhances melphalan cytotoxicity in preclinical models of multiple myeloma. Br J Haematol. 2011 Mar; 152(5):579-92.
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Regulation of the lifespan in dendritic cell subsets. Mol Immunol. 2007 Apr; 44(10):2558-65.
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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med. 2004 Nov; 10(11):1251-6.
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International Hermelin Brain Tumor Center Symposium on Apoptosis. Cell Death Differ. 2003 Sep; 10(9):1112-5.
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Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. Gene Ther. 2002 Sep; 9(18):1262-70.
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Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores. J Biol Chem. 2002 Mar 15; 277(11):9219-25.
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Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med. 2001 Nov 05; 194(9):1325-37.
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Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesothelioma. Cancer Gene Ther. 2001 Aug; 8(8):547-54.
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A role for mitochondrial Bak in apoptotic response to anticancer drugs. J Biol Chem. 2001 Sep 07; 276(36):34307-17.