"Genes, src" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.
| Descriptor ID |
D016391
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.570
|
| Concept/Terms |
src Oncogene- src Oncogene
- Oncogene, src
- Oncogenes, src
- src Oncogenes
- v-src Oncogenes
- Oncogene, v-src
- Oncogenes, v-src
- v src Oncogenes
- v-src Oncogene
- v-src Genes
- Gene, v-src
- Genes, v-src
- v src Genes
- v-src Gene
c-src Genes- c-src Genes
- Gene, c-src
- Genes, c-src
- c src Genes
- c-src Gene
- c-src Proto-Oncogenes
- Proto-Oncogene, c-src
- Proto-Oncogenes, c-src
- c src Proto Oncogenes
- c-src Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, src".
Below are MeSH descriptors whose meaning is more specific than "Genes, src".
This graph shows the total number of publications written about "Genes, src" by people in this website by year, and whether "Genes, src" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 1 | 1 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, src" by people in Profiles.
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Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PLoS One. 2023; 18(3):e0281063.
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IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2. Toxicol Appl Pharmacol. 2020 08 15; 401:115092.
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Personalized Cancer Therapy: YES1 Is the New Kid on the Block. Cancer Res. 2019 11 15; 79(22):5702-5703.
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A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-small cell lung cancer. Sci Rep. 2019 03 20; 9(1):4819.
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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. PLoS One. 2012; 7(7):e41171.
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Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin. Cancer. 2009 Apr 15; 115(8):1753-64.
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Coregulators: from whence came these "master genes". Mol Endocrinol. 2007 May; 21(5):1009-13.
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Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells. J Exp Ther Oncol. 2007; 6(3):205-17.
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The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors. Cancer. 2006 Oct 15; 107(8):1918-29.
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Inhibition of Src kinase activity by Ad-mda7 suppresses vascular endothelial growth factor expression in prostate carcinoma cells. Mol Ther. 2005 Oct; 12(4):707-15.