"Genes, abl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
| Descriptor ID |
D016313
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.100
|
| Concept/Terms |
bcr-v-abl Oncogenes- bcr-v-abl Oncogenes
- Oncogene, bcr-v-abl
- Oncogenes, bcr-v-abl
- bcr v abl Oncogenes
- bcr-v-abl Oncogene
abl Oncogene- abl Oncogene
- Oncogene, abl
- Oncogenes, abl
- abl Oncogenes
- v-abl Oncogenes
- Oncogene, v-abl
- Oncogenes, v-abl
- v abl Oncogenes
- v-abl Oncogene
- v-abl Genes
- Gene, v-abl
- Genes, v-abl
- v abl Genes
- v-abl Gene
bcr-abl Proto-Oncogenes- bcr-abl Proto-Oncogenes
- Proto-Oncogene, bcr-abl
- Proto-Oncogenes, bcr-abl
- bcr abl Proto Oncogenes
- bcr-abl Proto-Oncogene
c-abl Genes- c-abl Genes
- Gene, c-abl
- Genes, c-abl
- c abl Genes
- c-abl Gene
- c-abl Proto-Oncogenes
- Proto-Oncogene, c-abl
- Proto-Oncogenes, c-abl
- c abl Proto Oncogenes
- c-abl Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, abl".
Below are MeSH descriptors whose meaning is more specific than "Genes, abl".
This graph shows the total number of publications written about "Genes, abl" by people in this website by year, and whether "Genes, abl" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 3 | 3 |
| 2002 | 2 | 2 | 4 |
| 2003 | 1 | 3 | 4 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 6 | 7 |
| 2008 | 5 | 3 | 8 |
| 2009 | 1 | 3 | 4 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 2 | 4 |
| 2013 | 1 | 2 | 3 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, abl" by people in Profiles.
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ABL kinases regulate the stabilization of HIF-1a and MYC through?CPSF1. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2210418120.
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Ontogeny of human B1 cells. Int J Hematol. 2020 May; 111(5):628-633.
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Philadelphia chromosome-positive acute lymphoblastic leukemia at first relapse in the era of tyrosine kinase inhibitors. Am J Hematol. 2019 12; 94(12):1388-1395.
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Which tyrosine-kinase inhibitor to use first in chronic phase chronic myelogenous leukemia? Expert Opin Pharmacother. 2015 May; 16(7):999-1007.
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Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia. Blood. 2013 Nov 21; 122(22):3694-6.
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Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med. 2013 Nov; 19(11):1513-7.
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The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis. Haematologica. 2013 Oct; 98(10):1510-6.
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Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene. J Lipid Res. 2013 Mar; 54(3):794-805.
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Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia. Leuk Lymphoma. 2013 Jan; 54(1):138-44.
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Predictive value of early molecular response in patients with chronic myeloid leukemia treated with first-line dasatinib. Blood. 2012 Jul 12; 120(2):291-4.