"Genes, abl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
| Descriptor ID |
D016313
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.100
|
| Concept/Terms |
bcr-v-abl Oncogenes- bcr-v-abl Oncogenes
- Oncogene, bcr-v-abl
- Oncogenes, bcr-v-abl
- bcr v abl Oncogenes
- bcr-v-abl Oncogene
abl Oncogene- abl Oncogene
- Oncogene, abl
- Oncogenes, abl
- abl Oncogenes
- v-abl Oncogenes
- Oncogene, v-abl
- Oncogenes, v-abl
- v abl Oncogenes
- v-abl Oncogene
- v-abl Genes
- Gene, v-abl
- Genes, v-abl
- v abl Genes
- v-abl Gene
bcr-abl Proto-Oncogenes- bcr-abl Proto-Oncogenes
- Proto-Oncogene, bcr-abl
- Proto-Oncogenes, bcr-abl
- bcr abl Proto Oncogenes
- bcr-abl Proto-Oncogene
c-abl Genes- c-abl Genes
- Gene, c-abl
- Genes, c-abl
- c abl Genes
- c-abl Gene
- c-abl Proto-Oncogenes
- Proto-Oncogene, c-abl
- Proto-Oncogenes, c-abl
- c abl Proto Oncogenes
- c-abl Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, abl".
Below are MeSH descriptors whose meaning is more specific than "Genes, abl".
This graph shows the total number of publications written about "Genes, abl" by people in this website by year, and whether "Genes, abl" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, abl" by people in Profiles.
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Ontogeny of human B1 cells. Int J Hematol. 2020 May; 111(5):628-633.
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Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia. Blood. 2013 Nov 21; 122(22):3694-6.
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Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med. 2013 Nov; 19(11):1513-7.
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The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis. Haematologica. 2013 Oct; 98(10):1510-6.
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Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia. Leuk Lymphoma. 2013 Jan; 54(1):138-44.
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The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Blood. 2011 Nov 10; 118(19):5250-4.
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A pathway-based gene signature correlates with therapeutic response in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Mod Pathol. 2010 Nov; 23(11):1524-34.
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Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation. Blood. 2009 Dec 17; 114(26):5271-8.
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Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up. Blood. 2009 Jun 18; 113(25):6322-9.
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Dasatinib-induced restoration of donor chimerism in BCR-ABL1-positive ALL after failure of imatinib therapy and allo-SCT. Bone Marrow Transplant. 2009 Apr; 43(7):579-81.