"Genes, bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
| Descriptor ID |
D019254
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.150
|
| Concept/Terms |
Genes, bcl-2- Genes, bcl-2
- Genes, bcl 2
- bcl-2 Genes
- Gene, bcl-2
- bcl 2 Genes
- bcl-2 Gene
c-bcl-2 Genes- c-bcl-2 Genes
- Gene, c-bcl-2
- Genes, c-bcl-2
- c bcl 2 Genes
- c-bcl-2 Gene
- c-bcl-2 Proto-Oncogenes
- Proto-Oncogene, c-bcl-2
- Proto-Oncogenes, c-bcl-2
- c bcl 2 Proto Oncogenes
- c-bcl-2 Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, bcl-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, bcl-2".
This graph shows the total number of publications written about "Genes, bcl-2" by people in this website by year, and whether "Genes, bcl-2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 3 | 0 | 3 |
| 1997 | 1 | 1 | 2 |
| 1998 | 3 | 2 | 5 |
| 1999 | 9 | 4 | 13 |
| 2000 | 4 | 5 | 9 |
| 2001 | 4 | 2 | 6 |
| 2002 | 1 | 3 | 4 |
| 2003 | 1 | 5 | 6 |
| 2004 | 2 | 1 | 3 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 3 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 5 | 6 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, bcl-2" by people in Profiles.
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MYC rearrangement and MYC/BCL2 double expression but not cell-of-origin predict prognosis in R-CHOP?treated diffuse large B-cell lymphoma. Eur J Haematol. 2020 Apr; 104(4):336-343.
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Advances in pathological understanding of high-grade B cell lymphomas. Expert Rev Hematol. 2018 08; 11(8):637-648.
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Restrained Terminal Differentiation and Sustained Stemness in Neonatal Skin by Ha-Ras and Bcl-2. Am J Dermatopathol. 2017 Mar; 39(3):199-203.
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IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation. Cancer Immunol Res. 2016 11; 4(11):983-994.
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MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199. Cell Rep. 2015 Dec 29; 13(12):2715-27.
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Production of hGFAP-DsRed transgenic Guangxi Bama mini-pigs via somatic cell nuclear transfer. Genet Mol Res. 2015 Dec 08; 14(4):16285-96.
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A clinician's guide to double hit lymphomas. Br J Haematol. 2015 Mar; 168(6):784-95.
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Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma. Clin Cancer Res. 2014 Oct 01; 20(19):5113-23.
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B-cell lymphomas with concurrent MYC and BCL2 abnormalities other than translocations behave similarly to MYC/BCL2 double-hit lymphomas. Mod Pathol. 2015 Feb; 28(2):208-17.
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Double hit lymphoma: the MD Anderson Cancer Center clinical experience. Br J Haematol. 2014 Sep; 166(6):891-901.