"Pyrimidine Dimers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.
| Descriptor ID |
D011740
|
| MeSH Number(s) |
D03.383.742.686.600 D13.695.578.424.600 D13.695.740.600
|
| Concept/Terms |
Pyrimidine Dimers- Pyrimidine Dimers
- Dimers, Pyrimidine
- Cyclobutane-Pyrimidine Dimers
- Cyclobutane Pyrimidine Dimers
- Dimers, Cyclobutane-Pyrimidine
Thymine-Cyclobutane Dimer- Thymine-Cyclobutane Dimer
- Dimer, Thymine-Cyclobutane
- Thymine Cyclobutane Dimer
- Thymine-Thymine Cyclobutane Dimer
- Cyclobutane Dimer, Thymine-Thymine
- Dimer, Thymine-Thymine Cyclobutane
- Thymine Thymine Cyclobutane Dimer
- Thymine Dimers
- Dimers, Thymine
|
Below are MeSH descriptors whose meaning is more general than "Pyrimidine Dimers".
Below are MeSH descriptors whose meaning is more specific than "Pyrimidine Dimers".
This graph shows the total number of publications written about "Pyrimidine Dimers" by people in this website by year, and whether "Pyrimidine Dimers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1997 | 1 | 1 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pyrimidine Dimers" by people in Profiles.
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Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Nat Commun. 2017 07 18; 8:16102.
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Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage. PLoS One. 2013; 8(2):e55989.
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XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells. DNA Repair (Amst). 2006 May 10; 5(5):641-8.
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DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA. J Biol Chem. 2005 Dec 02; 280(48):39982-9.
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High-efficiency bypass of DNA damage by human DNA polymerase Q. EMBO J. 2004 Nov 10; 23(22):4484-94.
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Impact of p210(Bcr-Abl) on ultraviolet C wavelength-induced DNA damage and repair. Clin Cancer Res. 2003 Sep 01; 9(10 Pt 1):3722-30.
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Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlight. Nucleic Acids Res. 2003 Aug 01; 31(15):4541-52.
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Evidence that nucleotide excision repair is attenuated in bax-deficient mammalian cells following ultraviolet irradiation. Exp Cell Res. 2002 Aug 15; 278(2):158-65.
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Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair. Mol Cell Biol. 2001 Feb; 21(3):713-20.
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Dancing with the elephants: envisioning the structural biology of DNA repair pathways. Mutat Res. 2000 Aug 30; 460(3-4):139-41.