"Peptide Nucleic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.
| Descriptor ID |
D020135
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| MeSH Number(s) |
D13.695.578.424.550
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peptide Nucleic Acids".
Below are MeSH descriptors whose meaning is more specific than "Peptide Nucleic Acids".
This graph shows the total number of publications written about "Peptide Nucleic Acids" by people in this website by year, and whether "Peptide Nucleic Acids" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 2 | 3 |
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Below are the most recent publications written about "Peptide Nucleic Acids" by people in Profiles.
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Chimeric peptide nucleic acid compounds modulate splicing of the bcl-x gene in vitro and in vivo. Nucleic Acids Res. 2005; 33(20):6547-54.
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Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Nucleic Acids Res. 2005; 33(15):4914-21.
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Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis. Mol Cancer Ther. 2005 May; 4(5):779-86.
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Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter. Oncol Res. 2005; 15(7-8):373-83.