"Aconitine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.
| Descriptor ID |
D000157
|
| MeSH Number(s) |
D02.455.849.291.037 D03.132.030
|
| Concept/Terms |
Aconitine- Aconitine
- Acetylbenzoylaconine
- Acetylbenzoyl-aconine
- Acetylbenzoyl aconine
|
Below are MeSH descriptors whose meaning is more general than "Aconitine".
Below are MeSH descriptors whose meaning is more specific than "Aconitine".
This graph shows the total number of publications written about "Aconitine" by people in this website by year, and whether "Aconitine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aconitine" by people in Profiles.
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Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. Heart Rhythm. 2014 Mar; 11(3):492-501.
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The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett. 2013 Feb 04; 216(2-3):86-99.
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Role of a7- and a4?2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory. Int J Neuropsychopharmacol. 2013 Jun; 16(5):1105-13.
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Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine. Xenobiotica. 2012 Jun; 42(6):518-25.
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NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures. Mol Brain. 2009 Oct 05; 2:31.
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Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit. Neuropharmacology. 2007 Dec; 53(7):863-9.
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Frequency gradients during two different forms of fibrillation in the canine atria. Heart Rhythm. 2007 Oct; 4(10):1315-23.
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Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury. Eur J Pharmacol. 2000 Sep 15; 404(1-2):221-9.
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Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons. J Neurophysiol. 2000 May; 83(5):2682-90.
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Effect of quinidine and tetrodotoxin on the activation of non-adrenergic nerves in guinea-pig trachealis muscle. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987; 86(1):11-5.