"Ryanodine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
Descriptor ID |
D012433
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MeSH Number(s) |
D02.455.849.291.686 D03.132.740 D03.383.129.578.805
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ryanodine".
Below are MeSH descriptors whose meaning is more specific than "Ryanodine".
This graph shows the total number of publications written about "Ryanodine" by people in this website by year, and whether "Ryanodine" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 1 | 1 | 2 |
2008 | 0 | 1 | 1 |
2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ryanodine" by people in Profiles.
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Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor. PLoS One. 2013; 8(6):e66634.
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Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK. J Neurophysiol. 2008 Mar; 99(3):1565-71.
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Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies. Neuroscience. 1999; 92(2):499-513.
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Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding. Am J Physiol. 1999 Jan; 276(1 Pt 1):C46-53.
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Two structural configurations of the skeletal muscle calcium release channel. Nat Struct Biol. 1996 Jun; 3(6):547-52.
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Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca(2+)-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles. J Membr Biol. 1993 Jul; 135(1):49-59.
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Inhibition of dihydropyridine-sensitive calcium channels by the plant alkaloid ryanodine. FEBS Lett. 1989 Feb 27; 244(2):333-7.
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Ryanodine receptor of skeletal muscle is a gap junction-type channel. Science. 1988 Oct 07; 242(4875):99-102.