"Aphidicolin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
| Descriptor ID |
D016590
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| MeSH Number(s) |
D02.455.849.291.075
|
| Concept/Terms |
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer- Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
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Below are MeSH descriptors whose meaning is more general than "Aphidicolin".
Below are MeSH descriptors whose meaning is more specific than "Aphidicolin".
This graph shows the total number of publications written about "Aphidicolin" by people in this website by year, and whether "Aphidicolin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aphidicolin" by people in Profiles.
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Activation of a p53-mediated apoptotic pathway in quiescent lymphocytes after the inhibition of DNA repair by fludarabine. Clin Cancer Res. 2003 Aug 01; 9(8):3204-12.
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The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer Res. 2002 Jul 15; 62(14):4054-60.
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Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science. 2000 Mar 03; 287(5458):1644-7.
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Biochemical characterization of the protein activity responsible for high molecular weight DNA fragmentation during drug-induced apoptosis. Cancer Res. 1997 Aug 15; 57(16):3407-14.
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A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics. 1996 Jul 01; 35(1):87-93.
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Expression of proliferation-associated nuclear autoantigens, p330d/CENP-F and PCNA, in differentiation and in drug-induced growth inhibition using two-parameter flow cytometry. Cell Prolif. 1996 Apr; 29(4):183-96.
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High molecular weight DNA fragmentation: a critical event in nucleoside analogue-induced apoptosis in leukemia cells. Clin Cancer Res. 1995 Sep; 1(9):1005-13.
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Induction of apoptosis by gemcitabine. Semin Oncol. 1995 Aug; 22(4 Suppl 11):19-25.
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Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother Pharmacol. 1995; 36(3):181-8.
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Regulation of gene expression in the mouse oocyte and early preimplantation embryo: developmental changes in Sp1 and TATA box-binding protein, TBP. Development. 1994 Aug; 120(8):2347-57.